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DGKH encodes a member of the diacylglycerol kinase (DGK) enzyme family of proteins, specifically the type II DGK subfamily. Additionally we are shipping Diacylglycerol Kinase, eta Antibodies (29) and many more products for this protein.
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several single variants and genes showed strong association with Panic Disorders, where DGKH was found to be the strongest Panic Disorder associated gene. Interestingly DGKH has previously demonstrated genome-wide significant association with bipolar disorder as well as evidence of association to other mental disorders.
DGKeta-Pleckstrin (show PLEK Proteins) Homology Domain preferentially interacts with Phosphatidylinositol 4,5-Bisphosphate and has crucial roles in regulating the subcellular localization and physiological function of DGKeta.
This study demonstrated that significant association of the DGKH risk haplotype with increased amygdala volume in Bipolar disorder, but not in schizophreia or healthy controls.
These findings implicate a link between nucleotide variant of DGKH and a cause for a complex-trait disease, calcium oxalate stone
DGKK variants are associated with hypospadias
expressions of DGKeta and DGKzeta (show DGKZ Proteins) were increased and decreased, respectively, whereas those of DGKgamma and DGKepsilon remained unchanged. This is the first report that describes the differential regulation of DGK (show DGKB Proteins) isoforms in normal and failing human hearts.
Differential effects of DGKH in healthy controls vs the bipolar high-risk group manifest as a failure to disengage default-mode regions in those at familial risk carrying the risk haplotype.
Four DGKH markers are linked to adult attention-hyperactivity disorder and seven to unipolar depression, making DGKH a risk factor gene for bipolar disorder, unipolar depression and adult attention-deficit hyperactivity disorder.
Increased gene expression of diacylglycerol kinase eta is found in brain tissue from patients with bipolar disorder.
Although the association was not strong, the result of this study would support the association between DGKH and BD.
This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family of proteins, specifically the type II DGK subfamily. Members of this family are involved in regulating the intracellular concentrations of diacylglycerol and phosphatidic acid. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
diacylglycerol kinase eta
, diacylglycerol kinase, eta
, diacylglycerol kinase delta
, diacylglycerol kinase eta-like
, DAG kinase eta
, diglyceride kinase eta