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The enzyme encoded by DGAT1 utilizes diacylglycerol and fatty acyl CoA as substrates in order to catalyze the final stage of triacylglycerol synthesis. Additionally we are shipping Diacylglycerol O-Acyltransferase 1 Kits (9) and Diacylglycerol O-Acyltransferase 1 Proteins (8) and many more products for this protein.
Showing 10 out of 73 products:
Dog (Canine) Polyclonal DGAT1 Primary Antibody for EIA, IHC (p) - ABIN374862
Bagnato, Igal: Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts. in The Journal of biological chemistry 2003
Data indicate no clinically relevant pharmacokinetic interaction between DGAT-1 inhibitor pradigastat and rosuvastatin.
the apparent lack of therapeutic window owing to GI side effects of AZD7687, particularly diarrhoea, makes the utility of DGAT1 inhibition as a novel treatment for diabetes and obesity questionable.
Downregulation of CLDN1 (show CLDN1 Antibodies) was associated with altered fatty acid homeostasis in the absence of DGAT1.
MGAT2 (show MGAT2 Antibodies) functions as a dimeric or tetrameric protein and selectively heterodimerizes with DGAT1 in mammalian cells
The structure-activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described.
adipose overexpression of Dgat1 gene in transgenic mice leads to diet-inducible insulin (show INS Antibodies) resistance.
Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core
results identify DGAT1 loss-of-function mutations as a rare cause of congenital diarrheal disorders
describe distinct but synergistic roles of the two DGATs in an integrated pathway of TAG synthesis and secretion, with DGAT2 (show DGAT2 Antibodies) acting upstream of DGAT1
a comprehensive evaluation of a small molecule inhibitor for DGAT1 and suggests that pharmacological inhibition of DGAT1 holds promise in treating diverse metabolic disorders.
Total retinyl-ester synthase activity was reduced in both dgat1(-/-) retina and retinal pigment epithelium.
F3MB(PANDER (show FAM3B Antibodies)) decreases mice hepatic triglyceride and is associated with decreased DGAT1 expression
loss of DGAT1 reproduces the lipid abnormalities seen in severe human heart failure.
TNFalpha mediates saturated fatty acid-induced osteoclastogenesis that can be prevented by DGAT activation or supplementation with OA.
Compared with wild-type mice, triglyceride and DGAT1 content were approximately fourfold and 50% increased in posterior tibial muscle of the transgenic mice, respectively, while a little increase in cardiac muscle.
Diacylglycerol acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut (show GUSB Antibodies) hormone release.
Intestinal DGAT1 inhibition or deficiency acutely delayed gastric emptying and inhibited chylomicron secretion; however, the latter occurred when gastric emptying was normal or when lipid was administered directly into the small intestine.
analysis ofsubstrate and stereo/regioselectivity of adipose triglyceride lipase (show PNPLA2 Antibodies), hormone-sensitive lipase (show LIPE Antibodies), and diacylglycerol-O-acyltransferases
Deletion of DGAT1 in mice provides a model of leanness and extended lifespan that is independent of calorie restriction.
Lack of DGAT1 is atheroprotective, implicating an additional application of DGAT1 inhibitors with regard to maintaining cholesterol homeostasis and attenuating atherosclerosis.
Association of a novel mutation in DGAT1 that may be responsible for unsaturated milk fat in cattle.
An effect of DGAT1 identified on subcutaneous fat thickness.
Russian and Kazakh populations of the Kazakh white-headed breed were characterized by a high content of the AA genotype of RORC (show RORC Antibodies) (0.713 and 0.608, respectively) and of the AA genotype of DGAT1 (0.913 and 0.975)
Studied the occurrence of the DGAT1 p.Lys232Ala polymorphism in Romanian Holstein cattle and Romanian Buffalo breeds and further investigated its possible influence on fat percentage and fatty acid profiles.
Novel SNPs and INDEL polymorphism in DGAT1 are associated with milk production and protein and fat milk composition.
Single nucleotide polymorphisms in the DGAT1 gene significantly effected fat distribution in Chinese commercial cattle.
results indicated that knockdown of DGAT1 expression significantly reduced triglyceride content in bovine mammary epithelial cells
The use of leptin (show LEP Antibodies), leptin receptor (show LEPR Antibodies), and DGAT1 polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.
pleiotropic effects of polymorphism Ala to Lys (show LYZ Antibodies) amino acid substitution at position 232 in mammary gland tissue
The impact of different alleles of DGAT1 and leptin (show LEP Antibodies) on milk production in Giorlando cattle is reported.
ABI4 and ABI5 (show ABI5 Antibodies) synergistically regulate DGAT1 expression in Arabidopsis seedlings under stress.
Triacylglycerol synthesis by PDAT1 in the absence of DGAT1 activity is dependent on re-acylation of LPC (show PCSK7 Antibodies) by LPCAT2 (show LPCAT2 Antibodies).
ABI4 is essential for the activation of DGAT1 in Arabidopsis seedlings during nitrogen deficiency.
PDAT1 and DGAT1 have overlapping functions for triacylglycerol synthesis in both seed and pollen, and that the absence of their function leads not only to a reduction in TAG, but also to critical defects in normal pollen and embryo development.
The enzyme encoded by this gene utilizes diacylglycerol and fatty acyl CoA as substrates in order to catalyze the final stage of triacylglycerol synthesis. It is also involved in cellular as well as physiological metabolic processes.
diacylglycerol O-acyltransferase homolog 1
, acylcoenzyme A:diacylglycerol acyltransferase 1
, diacylglycerol O-acyltransferase 1
, ACAT related gene product 1
, acyl coenzyme A:cholesterol acyltransferase related gene 1
, acyl-CoA retinol O-fatty-acyltransferase
, acyl-CoA:diacylglycerol acyltransferase
, diglyceride acyltransferase
, retinol O-fatty-acyltransferase
, acyl-coenzyme A:diacylglycerol acyltransferase 1
, diacylglycerol acyltransferase
, diacylglycerol acyltransferase 1