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DIAPH1 is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Additionally we are shipping DIAPH1 Proteins (5) and DIAPH1 Kits (2) and many more products for this protein.
Showing 10 out of 45 products:
Dog (Canine) Monoclonal DIAPH1 Primary Antibody for IF, IP - ABIN968212
Li, Higgs: The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition. in Current biology : CB 2003
Show all 3 references for ABIN968212
Human Polyclonal DIAPH1 Primary Antibody for EIA, WB - ABIN488038
Higashi, Ikeda, Shirakawa, Kondo, Kawato, Horiguchi, Okuda, Okawa, Fukai, Nureki, Kita, Horiuchi: Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets. in The Journal of biological chemistry 2008
Show all 2 references for ABIN488038
Diaphanous-related formin (show DIAPH3 Antibodies) signaling plays a role in heart and vascular development and the maintenance of SMC (show DYM Antibodies) phenotype.
Liprin-alpha3 (show PPFIA3 Antibodies) uses an alpha-helical region to bind to mDia1, counteracting mouse Dia1 (show CYB5R3 Antibodies) activation by RhoA (show RHOA Antibodies).
Depleting FMNL1 (show FMNL1 Antibodies), another Formin (show FMN1 Antibodies) family member, resulted in reduced mDia1 expression, while RhoA (show RHOA Antibodies) inhibition did not alter mDia1 expression, which indicated that there was a FMNL1 (show FMNL1 Antibodies)-mDia1-Profilin1 (show PFN1 Antibodies) signaling pathway in mouse oocytes.
Mechanistically, mDia1 deficiency led to a downregulation of membrane-associated genes and a specific upregulation of CD14 (show CD14 Antibodies) messenger RNA in granulocytes, but not in other lineages.
Mammalian diaphanous-related formin 1 regulates GSK3beta (show GSK3b Antibodies)-dependent microtubule dynamics required for T cell migratory polarization.
mDia1 can efficiently put actin filaments under mechanical tension.
The active form of mDia1 localized to the apical membrane in exocrine pancreas cells; introduction of an active form of mDia1 leads to a marked increase in actin bundle density along the secretory vesicle lumen perimeter.
Dia1 (show CYB5R3 Antibodies) and Dia2 (show DIAPH3 Antibodies) are dynamic components of meiotic spindle and pole complex during meiotic maturation of oocytes.
Actin-capping protein is a novel regulator of microtubule stability that functions by antagonizing mDia1 activity toward actin filaments.
Full-length mouse mDia1 (mDia1-FL) forms tightly autoinhibited dimers that can only be partially activated by RhoA (show RHOA Antibodies).
functional complementation experiments and optogenetics to show that mDia1 cooperates with the Arp2 (show ACTR2 Antibodies)/3 complex in initiating lamellipodia and ruffles.
Capping protein and dia1 (show CYB5R3 Antibodies) functionally coregulate filament barbed-end assembly.
mDia1 displaced from the barbed end by CapZ Actin Capping Protein can randomly slide along the actin filament and later return.
Data indicate that diaphanous homolog 1 (Drosophila) protein (DIAPH1) stabilizes microtubules and reduces microtubule dynamics.
Patients with a homozygous nonsense DIAPH1 alteration (p.Gln778*) have MCP (show CD46 Antibodies) as well as reduced height and weight.
the RhoA (show RHOA Antibodies)-regulated formin (show FMN1 Antibodies) Dia1 (show CYB5R3 Antibodies) is involved in entosis downstream of LPAR2 (show LPAR2 Antibodies)
DIAPH1 has a critical role in generating F-actin structures and assisting the microtubule stabilization underlying proplatelet formation and platelet production
Dia1 (show CYB5R3 Antibodies), Dia2 (show DIAPH2 Antibodies), and Dia3 (show DIAPH2 Antibodies) are involved in ErbB2 (show ERBB2 Antibodies)-dependent capture of microtubules at the cell leading edge and ErbB2 (show ERBB2 Antibodies)-driven guided migration.
Mechanistically, mDia1 deficiency led to a downregulation of membrane-associated genes and a specific upregulation of CD14 (show NDUFA2 Antibodies) messenger RNA in granulocytes, but not in other lineages.
Depletion of DIAPH1 reduced metastasis 60-fold.
This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
diaphanous homolog 1 (Drosophila)
, diaphanous homolog 1
, diaphanous homolog 2
, protein diaphanous homolog 1
, protein diaphanous homolog 1-like
, diaphanous-related formin-1