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anti-Diaphanous Homolog 1 (Drosophila) (DIAPH1) Antibodies

DIAPH1 is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Additionally we are shipping DIAPH1 Proteins (5) and DIAPH1 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DIAPH1 307483  
DIAPH1 13367 O08808
DIAPH1 1729 O60610
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Top anti-DIAPH1 Antibodies at antibodies-online.com

Showing 10 out of 44 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Dog Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of mDia1 on a RSV-3T3 cell lysate. Lane of 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of the mouse anti-mDia1 antibody. Immunofluorescence staining of FHs cells (Normal human fetal lung fibroblasts, ATCC HTB-157). 50 μg Log in to see 5 to 6 Days
$205.42
Details
Mouse Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: H1299 B: Raji 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded human gastric tissue, using DIAPH1, antibody at 1:100 dilution. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image Confocal immunofluorescence analysis (Olympus FV10i) of methanol-fixed HeLa, using DIAPH1, antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with  (Red) at 1:2000. IHC-P Image DIAPH1 antibody [C2C3], C-term detects DIAPH1 protein at cytoplasm on human colon carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded colon carcinoma. DIAPH1 antibody [C2C3], C-term , dilution: 1:250. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged DIAPH1 is approximately 0.1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated ICC, IHC (p), WB   100 μL Log in to see 8 to 10 Days
$507.83
Details
Mouse Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$318.20
Details

DIAPH1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Rat (Rattus)
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Mouse (Murine)
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Human , ,
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Top referenced anti-DIAPH1 Antibodies

  1. Dog (Canine) Monoclonal DIAPH1 Primary Antibody for IF, IP - ABIN968212 : Li, Higgs: The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition. in Current biology : CB 2003 (PubMed)
    Show all 3 references for ABIN968212

  2. Human Polyclonal DIAPH1 Primary Antibody for EIA, WB - ABIN488038 : Higashi, Ikeda, Shirakawa, Kondo, Kawato, Horiguchi, Okuda, Okawa, Fukai, Nureki, Kita, Horiuchi: Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN488038

More Antibodies against DIAPH1 Interaction Partners

Mouse (Murine) Diaphanous Homolog 1 (Drosophila) (DIAPH1) interaction partners

  1. Diaphanous-related formin (show DIAPH3 Antibodies) signaling plays a role in heart and vascular development and the maintenance of SMC (show DYM Antibodies) phenotype.

  2. Liprin-alpha3 (show PPFIA3 Antibodies) uses an alpha-helical region to bind to mDia1, counteracting mouse Dia1 (show CYB5R3 Antibodies) activation by RhoA (show RHOA Antibodies).

  3. Depleting FMNL1 (show FMNL1 Antibodies), another Formin (show FMN1 Antibodies) family member, resulted in reduced mDia1 expression, while RhoA (show RHOA Antibodies) inhibition did not alter mDia1 expression, which indicated that there was a FMNL1 (show FMNL1 Antibodies)-mDia1-Profilin1 (show PFN1 Antibodies) signaling pathway in mouse oocytes.

  4. Mechanistically, mDia1 deficiency led to a downregulation of membrane-associated genes and a specific upregulation of CD14 (show CD14 Antibodies) messenger RNA in granulocytes, but not in other lineages.

  5. Mammalian diaphanous-related formin 1 regulates GSK3beta (show GSK3b Antibodies)-dependent microtubule dynamics required for T cell migratory polarization.

  6. mDia1 can efficiently put actin filaments under mechanical tension.

  7. The active form of mDia1 localized to the apical membrane in exocrine pancreas cells; introduction of an active form of mDia1 leads to a marked increase in actin bundle density along the secretory vesicle lumen perimeter.

  8. Dia1 (show CYB5R3 Antibodies) and Dia2 (show DIAPH3 Antibodies) are dynamic components of meiotic spindle and pole complex during meiotic maturation of oocytes.

  9. Actin-capping protein is a novel regulator of microtubule stability that functions by antagonizing mDia1 activity toward actin filaments.

  10. Full-length mouse mDia1 (mDia1-FL) forms tightly autoinhibited dimers that can only be partially activated by RhoA (show RHOA Antibodies).

Human Diaphanous Homolog 1 (Drosophila) (DIAPH1) interaction partners

  1. Loss-of-function variants in DIAPH1 is associated with syndromic microcephaly, blindness, and early onset seizures.

  2. functional complementation experiments and optogenetics to show that mDia1 cooperates with the Arp2 (show ACTR2 Antibodies)/3 complex in initiating lamellipodia and ruffles.

  3. Capping protein and dia1 (show CYB5R3 Antibodies) functionally coregulate filament barbed-end assembly.

  4. mDia1 displaced from the barbed end by CapZ Actin Capping Protein can randomly slide along the actin filament and later return.

  5. Data indicate that diaphanous homolog 1 (Drosophila) protein (DIAPH1) stabilizes microtubules and reduces microtubule dynamics.

  6. Patients with a homozygous nonsense DIAPH1 alteration (p.Gln778*) have MCP (show CD46 Antibodies) as well as reduced height and weight.

  7. the RhoA (show RHOA Antibodies)-regulated formin (show FMN1 Antibodies) Dia1 (show CYB5R3 Antibodies) is involved in entosis downstream of LPAR2 (show LPAR2 Antibodies)

  8. DIAPH1 has a critical role in generating F-actin structures and assisting the microtubule stabilization underlying proplatelet formation and platelet production

  9. Dia1 (show CYB5R3 Antibodies), Dia2 (show DIAPH2 Antibodies), and Dia3 (show DIAPH2 Antibodies) are involved in ErbB2 (show ERBB2 Antibodies)-dependent capture of microtubules at the cell leading edge and ErbB2 (show ERBB2 Antibodies)-driven guided migration.

  10. Mechanistically, mDia1 deficiency led to a downregulation of membrane-associated genes and a specific upregulation of CD14 (show NDUFA2 Antibodies) messenger RNA in granulocytes, but not in other lineages.

DIAPH1 Antigen Profile

Protein Summary

This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene names and symbols associated with DIAPH1

  • diaphanous homolog 1 (Drosophila) (DIAPH1) antibody
  • diaphanous-related formin 1 (DIAPH1) antibody
  • diaphanous-related formin 1 (diaph1) antibody
  • diaphanous-related formin 1 (Diaph1) antibody
  • diaphanous homolog 1 (Drosophila) (diaph1) antibody
  • diaphanous homolog 1 (Drosophila) (Diap1) antibody
  • D18Wsu154e antibody
  • DFNA1 antibody
  • DIA1 antibody
  • Diap1 antibody
  • Diaph1 antibody
  • DIAPH2 antibody
  • DRF1 antibody
  • hDIA1 antibody
  • LFHL1 antibody
  • mKIAA4062 antibody
  • p140mDia antibody

Protein level used designations for DIAPH1

diaphanous homolog 1 (Drosophila) , diaphanous homolog 1 , diaphanous homolog 2 , protein diaphanous homolog 1 , protein diaphanous homolog 1-like , diaphanous-related formin-1 , mDIA1

GENE ID SPECIES
100684883 Canis lupus familiaris
700918 Macaca mulatta
786565 Bos taurus
733754 Xenopus (Silurana) tropicalis
100072186 Equus caballus
374040 Gallus gallus
307483 Rattus norvegicus
100457442 Pongo abelii
100478130 Ailuropoda melanoleuca
100562222 Anolis carolinensis
13367 Mus musculus
1729 Homo sapiens
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