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The product of DIAPH2 belongs to the diaphanous subfamily of the formin homology family of proteins. Additionally we are shipping DIAPH2 Antibodies (49) and and many more products for this protein.
Dia1 (show CYB5R3 ELISA Kits), Dia2, and Dia3 are involved in ErbB2 (show ERBB2 ELISA Kits)-dependent capture of microtubules at the cell leading edge and ErbB2 (show ERBB2 ELISA Kits)-driven guided migration.
DIAPH2 has been associated with premature ovarian insufficiency, an aging phenotype in humans.
In podocytes, INF2 appears to be an important modulator of actin-dependent behaviors that are under the control of Rho/mDia signaling.
Dia2 and DIP (show TSC22D3 ELISA Kits) co-tether to nascent blebs and this linkage is required for bleb formation.
Long HIV filopodial formation in infected dendritic cells was dependent on the formin (show FMN1 ELISA Kits) diaphanous 2 (Diaph2)
Our results indicated that DIAPH2 may be a polygenic pleiotropy for premature ovarian failure (POF (show POF1B ELISA Kits)) and AMD (show AMD1 ELISA Kits).
Dia2 plays an important role in formation of lamellipodia.
co-injection of antisense MOs (show MOS ELISA Kits) of Diaphanous-related formin 2 and profilin I (show PFN1 ELISA Kits), but not zebrafish profilin II (show PFN2 ELISA Kits), resulted in a synergistic inhibition of gastrulation cell movements[Diaphanous-related formin 2, PROFILIN 1 (show PFN1 ELISA Kits) ]
These results imply that RhoD activated by FGF signaling forms cytoneme-like protrusions through activation of mDia3C, which induces actin filament formation
actin cytoskeleton regulated by Rho-mDia pathway is critical for the integrity of the adherens junctions and the polarity of neuroepithelial cells
Cdc42 (show CDC42 ELISA Kits), and its effector, mDia3, regulate microtubule attachment to kinetochores
These results indicate that RhoA (show RHOA ELISA Kits)-dependent signaling through mDia1/2 and the MRTFs is important for SMC (show DYM ELISA Kits)-specific gene expression in smooth muscle cells.
analysis of interactions between mDia isoforms 1, 2, and 3 and RhoA (show RHOA ELISA Kits), Rac1, and Cdc42 (show CDC42 ELISA Kits)
The product of this gene belongs to the diaphanous subfamily of the formin homology family of proteins. This gene may play a role in the development and normal function of the ovaries. Defects in this gene have been linked to premature ovarian failure 2. Alternatively spliced transcript variants encoding different isoforms have been identified.
diaphanous homolog 2 (Drosophila)
, diaphanous 2
, protein diaphanous homolog 2-like
, diaphanous-related formin-2
, protein diaphanous homolog 2
, diaphanous homolog 2