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DIAPH3 encodes a member of the diaphanous subfamily of the formin family. Additionally we are shipping DIAPH3 Antibodies (60) and DIAPH3 Proteins (4) and many more products for this protein.
findings add more complexity to the mDia2 activity cycle by showing that the open conformation may control actin dynamics also through actin-independent regulation of the proteasome
Ineffective erythropoiesis caused by binucleated late-stage erythroblasts in mDia2 hematopoietic specific knockout mice.
the interactome of auto-inhibited and constitutively active mDia2, is reported.
mDia2-deficient erythroid cells differentiate normally, though in a delayed manner, but exhibit cytokinesis failure with decreased accumulation of F-actin in the cleavage furrow during late differentiation from proerythroblasts
Diaphanous homolog 3 (Diap3) overexpression causes progressive hearing loss and inner hair cell defects in a transgenic mouse model of human deafness.
Dia1 (show CYB5R3 ELISA Kits) and Dia2 are dynamic components of meiotic spindle and pole complex during meiotic maturation of oocytes.
Microtubules strongly inhibit actin polymerization by mDia2.
Results indicate that ROCK-dependent phosphorylation of the mDia2 DAD is an important determinant of mDia2 activity and that this signalling mechanism affects actin polymerization and smooth muscle cell-specific gene expression.
Results show that targeting of mDia2 to the cleavage furrow requires not only its binding to RhoA (show RHOA ELISA Kits) but also its diaphanous-inhibitory domain, and identify anillin (show ANLN ELISA Kits) as a novel mDia2 interaction partner.
Int (show TSC22D3 ELISA Kits)roduction of the mDia2 inhibitor DIP/WISH/SPIN90 into ce (show DIAPH2 ELISA Kits)lls triggers non-apoptotic membrane blebbing. The results infer a role for mDia2 in (show ACTR2 ELISA Kits)the maintenance of actin networks supporting the cell cortex.
mDia2 and CXCR4 (show CXCR4 ELISA Kits) associate in blebs upon CXCL12 (show CXCL12 ELISA Kits) stimulation. Both CXCR4 (show CXCR4 ELISA Kits) and RhoA (show RHOA ELISA Kits) are required for CXCL12 (show CXCL12 ELISA Kits)-induced blebbing
we use a simple cellular system to examine fundamental features of formin (show FMN1 ELISA Kits)-mediated filopodial assembly, using constitutively active constructs of the formins mDia2 and FMNL3 (show FMNL3 ELISA Kits)
results suggest that inhibition of MT stability arising from DIAPH3 downregulation enhances susceptibility to MT poisons, and that the DIAPH3 network potentially reports taxane sensitivity in human tumors
Dia1 (show CYB5R3 ELISA Kits), Dia2 (show DIAPH2 ELISA Kits), and Dia3 (show DIAPH2 ELISA Kits) are involved in ErbB2 (show ERBB2 ELISA Kits)-dependent capture of microtubules at the cell leading edge and ErbB2 (show ERBB2 ELISA Kits)-driven guided migration.
An mDia2/ROCK signaling axis regulates invasive egress from epithelial ovarian cancer spheroids.
TGF-beta promotes association of mDia2 with actin stress fibers, which further drives stress fiber formation and myofibroblast differentiation
In human tumours, DIAPH3 down-regulation was associated with aggressive or metastatic disease.
isoform-selective actin assembly by DIAPH3 exerts specific and differentially regulated functions during cell adhesion and motility.
the amino terminus of mDia2 serves as a coincidence detection module, directing mDia2 to the plasma membrane through interactions with phospholipids and activated Rif
These findings reveal a key role for mDia3 and its regulation by Aurora B (show AURKB ELISA Kits) phosphorylation in achieving proper stable kinetochore microtubule attachment.
This gene encodes a member of the diaphanous subfamily of the formin family. Members of this family are involved in actin remodeling and regulate cell movement and adhesion. Mutations in this gene are associated with autosomal dominant auditory neuropathy 1. Multiple transcript variants encoding different isoforms have been found for this gene.
diaphanous homolog 3
, protein diaphanous homolog 3
, diaphanous homolog 3 (Drosophila)
, protein diaphanous homolog 3-like
, diaphanous-related formin
, diaphanous-related formin-3