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The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains.
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Dkkl1 may not be essential for normal brain organization, but could exert import functions during pathological conditions such as tumorigenesis and cancer progression.
DKKL1/Dkkl1 may play an important role in testicular development and spermatogenesis and may be an important factor in male infertility.
DKKL1 is a mammalian-specific acrosomal protein that is not essential either for development or fertility.
DKKL1 is a mammalian-specific, acrosomal protein that strongly affects in vitro fertilization, although the effect is attenuated in vivo.
Results suggest that DNA methylation (show HELLS Antibodies) is not the primary determinant of Soggy/Tead2 (show TEAD2 Antibodies) expression.
Dkkl1 is a negative regulator of adult testis homeostasis that specifically controls the number of postpubertal spermatocytes.
SLY1 (show SASH3 Antibodies) interacts with acrosomal protein DKKL1, histone acetyltransferase KAT5 (show KAT5 Antibodies) & microtubule-associated protein (show SPAG5 Antibodies) APPBP2 (show APPBP2 Antibodies); data suggest SLY1 (show SASH3 Antibodies) may be involved in spermiogenesis processes, including control of gene expression & acrosome development or function
Findings suggest that Dkk-3 plays a role in the regulation of cell interactions during retinoic acid-induced neuronal differentiation; effect on apoptosis was also observed upon expression of the related protein Dkkl-1
Unliganded VDR (show CYP27B1 Antibodies) upregulates the expression of hairless (show HR Antibodies), the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 and SOSTDC1 (show SOSTDC1 Antibodies).
The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, dickkopf-like 1 (soggy)
, dickkopf-like protein 1
, protein soggy-1
, soggy 1
, cancer/testis antigen 34