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DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008].. Additionally we are shipping DEF6 Proteins (4) and many more products for this protein.
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Human Polyclonal DEF6 Primary Antibody for EIA, WB - ABIN951875
Zhao, Li, Bradfield, Zhang, Mentch, Wang, Sleiman, Kim, Glessner, Hou, Keating, Thomas, Garris, Deliard, Frackelton, Otieno, Chiavacci, Berkowitz, Hakonarson, Grant: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. in BMC medical genetics 2010
Show all 4 references for ABIN951875
Human Monoclonal DEF6 Primary Antibody for IHC (p), IP - ABIN565491
Worthmann, Leitges, Teng, Sestu, Tossidou, Samson, Haller, Huber, Schiffer: Def-6, a novel regulator of small GTPases in podocytes, acts downstream of atypical protein kinase C (aPKC) ?/?. in The American journal of pathology 2013
Human Polyclonal DEF6 Primary Antibody for ELISA, WB - ABIN185227
Tanaka, Bi, Kitamura, Hong, Altman, Matsumoto, Tabata, Lebedeva, Bushway, Altman: SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells. in Immunity 2003
Swap70b and Def6a delineate Wnt11 (show WNT11 Antibodies) and Wnt5b (show WNT5B Antibodies) signalling pathways and have roles in convergent and extension cell movement during zebrafish gastrulation
def6 morphants phenocopy Wnt5b (show WNT5B Antibodies) mutants and ectopic overexpression of def6 essentially rescues Wnt5b (show WNT5B Antibodies) morphants, indicating a novel role for def6 as a central GEF (show SLC2A4RG Antibodies) downstream of Wnt5b (show WNT5B Antibodies) signaling
These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling.
SLAT is an IP3R1 (show ITPR1 Antibodies)-interacting protein required for T cell activation.
PKClambda/iota was identified as an important factor for actin cytoskeletal regulation in podocytes and Def-6 as a specific downstream target of PKClambda/iota that regulates the activity of small GTPases and subsequently the actin cytoskeleton of podocytes.
Data suggest that SLAT acts as a negative modulator of RANKL (show TNFSF11 Antibodies)-induced osteoclastogenesis.
SLAT-mediated nuclear factor of activated T-cell (show NFATC3 Antibodies) (NFAT)1 (show NFAT1 Antibodies) activation is required for efficient expansion of CD8 (show CD8A Antibodies)+ T cells during the primary response but is not necessary for cytotoxic T lymphocyte (CTL) differentiation.
SLAT/Def6 plays a major role in the T cell-mediated autoimmune processes that bring about the inflammatory eye disease, experimental autoimmune uveitis.
plays a role in Th2 development and/or activation, perhaps by interfering with ZAP-70 (show ZAP70 Antibodies) signaling
tyrosine-phosphorylation-mediated relocalization of SLAT to the site of antigen recognition is required for SLAT to exert its pivotal role in NFAT (show NFATC1 Antibodies)-dependent CD4 (show CD4 Antibodies)(+) T cell differentiation.
IRF-4-binding protein sequestered IRF-4 (show IRF4 Antibodies) and prevented it from targeting the transcriptional regulatory regions of the genes that encode IL-17 (show IL17A Antibodies) and IL-21 (show IL21 Antibodies).
IBP/Def6 as a novel component of the TLR4 (show TLR4 Antibodies)-induced signaling cascade that controls the production of proinflammatory cytokines
DEF6 (show DEFA6 Antibodies) expression may serve as an independent prognostic factor, and interacted positively with p16 (show CDKN2A Antibodies) toward high tumor stage and shorter survival.
IBP (show TSPO Antibodies) was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases
DEF6 (show DEFA6 Antibodies), a novel substrate for the Tec (show NR4A3 Antibodies) kinase ITK (show ITK Antibodies), contains a glutamine (show GFPT1 Antibodies)-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.
Molecular cloning of IBP (show TSPO Antibodies), a guanine nucleotide exchange factor (show RASGRF1 Antibodies), which is highly expressed in the immune system.
IBP (show TSPO Antibodies) is a novel guanine nucleotide exchange factor (show RASGRF1 Antibodies) and is recruited to the immunological synapse by T cell receptor engagement
DEF6 not only activates Rho-family GTPases but also cooperates with activated Rac1 to exert its cellular function
Overexpression of the Interferon regulatory factor 4 (show IRF4 Antibodies)-binding protein is associated with Colorectal Carcinoma.
DEF6 (show DEFA6 Antibodies), a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42 (show CDC42 Antibodies), and RhoA (show RHOA Antibodies).
DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003
differentially expressed in FDCP 6 homolog (mouse)
, differentially expressed in FDCP 6 homolog
, IRF-4-binding protein
, IRF4-binding protein
, SWAP-70-like adapter of T-cells
, SWAP-70-like adaptor protein of T cells