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anti-Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) Antibodies

DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008].. Additionally we are shipping DEF6 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DEF6 23853 Q8C2K1
DEF6 50619 Q9H4E7
DEF6 309642  
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Top anti-DEF6 Antibodies at antibodies-online.com

Showing 10 out of 64 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB western blot analysis of DEF6 Antibody (C-term) in A375 cell line lysates (35ug/lane). This demonstrates the DEF6 antibody detected the DEF6 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated ELISA, WB ABIN185227 (1µg/ml) staining of Human Thymus lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-DEF6 AntibodyTitration: 1.0 µg/mL  Positive Control: U937 Whole Cell 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB DEF6 Antibody (C-term)  western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the DEF6 antibody detected the DEF6 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to DEF6 on formalin-fixed paraffin-embedded human lymph node [antibody concentration 3 ug/ml] Detection limit for recombinant GST tagged DEF6 is approximately 1ng/ml as a capture antibody. 50 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated IF, IHC (p), WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated IHC (p), WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details

DEF6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,
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Rat (Rattus) ,
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Top referenced anti-DEF6 Antibodies

  1. Human Polyclonal DEF6 Primary Antibody for EIA, WB - ABIN951875 : Zhao, Li, Bradfield, Zhang, Mentch, Wang, Sleiman, Kim, Glessner, Hou, Keating, Thomas, Garris, Deliard, Frackelton, Otieno, Chiavacci, Berkowitz, Hakonarson, Grant: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. in BMC medical genetics 2010 (PubMed)
    Show all 4 references for ABIN951875

  2. Human Monoclonal DEF6 Primary Antibody for IHC (p), IP - ABIN565491 : Worthmann, Leitges, Teng, Sestu, Tossidou, Samson, Haller, Huber, Schiffer: Def-6, a novel regulator of small GTPases in podocytes, acts downstream of atypical protein kinase C (aPKC) ?/?. in The American journal of pathology 2013 (PubMed)

  3. Human Polyclonal DEF6 Primary Antibody for ELISA, WB - ABIN185227 : Tanaka, Bi, Kitamura, Hong, Altman, Matsumoto, Tabata, Lebedeva, Bushway, Altman: SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells. in Immunity 2003 (PubMed)

More Antibodies against DEF6 Interaction Partners

Zebrafish Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) interaction partners

  1. Swap70b and Def6a delineate Wnt11 (show WNT11 Antibodies) and Wnt5b (show WNT5B Antibodies) signalling pathways and have roles in convergent and extension cell movement during zebrafish gastrulation

  2. def6 morphants phenocopy Wnt5b (show WNT5B Antibodies) mutants and ectopic overexpression of def6 essentially rescues Wnt5b (show WNT5B Antibodies) morphants, indicating a novel role for def6 as a central GEF (show SLC2A4RG Antibodies) downstream of Wnt5b (show WNT5B Antibodies) signaling

Mouse (Murine) Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) interaction partners

  1. These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling.

  2. SLAT is an IP3R1 (show ITPR1 Antibodies)-interacting protein required for T cell activation.

  3. PKClambda/iota was identified as an important factor for actin cytoskeletal regulation in podocytes and Def-6 as a specific downstream target of PKClambda/iota that regulates the activity of small GTPases and subsequently the actin cytoskeleton of podocytes.

  4. Data suggest that SLAT acts as a negative modulator of RANKL (show TNFSF11 Antibodies)-induced osteoclastogenesis.

  5. SLAT-mediated nuclear factor of activated T-cell (show NFATC3 Antibodies) (NFAT)1 (show NFAT1 Antibodies) activation is required for efficient expansion of CD8 (show CD8A Antibodies)+ T cells during the primary response but is not necessary for cytotoxic T lymphocyte (CTL) differentiation.

  6. SLAT/Def6 plays a major role in the T cell-mediated autoimmune processes that bring about the inflammatory eye disease, experimental autoimmune uveitis.

  7. plays a role in Th2 development and/or activation, perhaps by interfering with ZAP-70 (show ZAP70 Antibodies) signaling

  8. tyrosine-phosphorylation-mediated relocalization of SLAT to the site of antigen recognition is required for SLAT to exert its pivotal role in NFAT (show NFATC1 Antibodies)-dependent CD4 (show CD4 Antibodies)(+) T cell differentiation.

  9. IRF-4-binding protein sequestered IRF-4 (show IRF4 Antibodies) and prevented it from targeting the transcriptional regulatory regions of the genes that encode IL-17 (show IL17A Antibodies) and IL-21 (show IL21 Antibodies).

  10. IBP/Def6 as a novel component of the TLR4 (show TLR4 Antibodies)-induced signaling cascade that controls the production of proinflammatory cytokines

Human Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) interaction partners

  1. IBP (show TSPO Antibodies) was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases

  2. DEF6 (show DEFA6 Antibodies), a novel substrate for the Tec (show NR4A3 Antibodies) kinase ITK (show ITK Antibodies), contains a glutamine (show GFPT1 Antibodies)-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.

  3. Molecular cloning of IBP (show TSPO Antibodies), a guanine nucleotide exchange factor (show RASGRF1 Antibodies), which is highly expressed in the immune system.

  4. IBP (show TSPO Antibodies) is a novel guanine nucleotide exchange factor (show RASGRF1 Antibodies) and is recruited to the immunological synapse by T cell receptor engagement

  5. DEF6 not only activates Rho-family GTPases but also cooperates with activated Rac1 to exert its cellular function

  6. Overexpression of the Interferon regulatory factor 4 (show IRF4 Antibodies)-binding protein is associated with Colorectal Carcinoma.

  7. DEF6 (show DEFA6 Antibodies), a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42 (show CDC42 Antibodies), and RhoA (show RHOA Antibodies).

DEF6 Antigen Profile

Protein Summary

DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003

Gene names and symbols associated with DEF6

  • differentially expressed in FDCP 6 homolog (mouse) (DEF6) antibody
  • differentially expressed in FDCP 6a homolog (mouse) (def6a) antibody
  • differentially expressed in FDCP 6 homolog (def6) antibody
  • differentially expressed in FDCP 6 homolog (LOC100498543) antibody
  • differentially expressed in FDCP 6 (Def6) antibody
  • differentially expressed in FDCP 6 homolog (mouse) (Def6) antibody
  • 2410003F05Rik antibody
  • 6430538D02Rik antibody
  • AV094905 antibody
  • Def6 antibody
  • IBP antibody
  • MGC68775 antibody
  • SLAT antibody
  • Slat2 antibody
  • Slat6 antibody
  • SWAP70L antibody
  • zgc:63721 antibody

Protein level used designations for DEF6

differentially expressed in FDCP 6 homolog (mouse) , differentially expressed in FDCP 6 homolog , DEF-6 , IRF-4-binding protein , IRF4-binding protein , SWAP-70-like adapter of T-cells , SWAP-70-like adaptor protein of T cells

GENE ID SPECIES
419893 Gallus gallus
462636 Pan troglodytes
394015 Danio rerio
398924 Xenopus laevis
100498543 Xenopus (Silurana) tropicalis
100053351 Equus caballus
23853 Mus musculus
50619 Homo sapiens
608163 Canis lupus familiaris
100154998 Sus scrofa
516457 Bos taurus
309642 Rattus norvegicus
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