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Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) ELISA Kits

DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008].. Additionally we are shipping DEF6 Antibodies (67) and DEF6 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse DEF6 DEF6 23853 Q8C2K1
Anti-Human DEF6 DEF6 50619 Q9H4E7
Anti-Rat DEF6 DEF6 309642  
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More ELISA Kits for DEF6 Interaction Partners

Zebrafish Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) interaction partners

  1. Swap70b and Def6a delineate Wnt11 (show WNT11 ELISA Kits) and Wnt5b (show WNT5B ELISA Kits) signalling pathways and have roles in convergent and extension cell movement during zebrafish gastrulation

  2. def6 morphants phenocopy Wnt5b (show WNT5B ELISA Kits) mutants and ectopic overexpression of def6 essentially rescues Wnt5b (show WNT5B ELISA Kits) morphants, indicating a novel role for def6 as a central GEF downstream of Wnt5b (show WNT5B ELISA Kits) signaling

Mouse (Murine) Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) interaction partners

  1. These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling.

  2. SLAT is an IP3R1 (show ITPR1 ELISA Kits)-interacting protein required for T cell activation.

  3. PKClambda/iota was identified as an important factor for actin cytoskeletal regulation in podocytes and Def-6 as a specific downstream target of PKClambda/iota that regulates the activity of small GTPases and subsequently the actin cytoskeleton of podocytes.

  4. Data suggest that SLAT acts as a negative modulator of RANKL (show TNFSF11 ELISA Kits)-induced osteoclastogenesis.

  5. SLAT-mediated nuclear factor of activated T-cell (show NFATC3 ELISA Kits) (NFAT)1 (show NFAT1 ELISA Kits) activation is required for efficient expansion of CD8 (show CD8A ELISA Kits)+ T cells during the primary response but is not necessary for cytotoxic T lymphocyte (CTL) differentiation.

  6. SLAT/Def6 plays a major role in the T cell-mediated autoimmune processes that bring about the inflammatory eye disease, experimental autoimmune uveitis.

  7. plays a role in Th2 development and/or activation, perhaps by interfering with ZAP-70 (show ZAP70 ELISA Kits) signaling

  8. tyrosine-phosphorylation-mediated relocalization of SLAT to the site of antigen recognition is required for SLAT to exert its pivotal role in NFAT (show NFATC1 ELISA Kits)-dependent CD4 (show CD4 ELISA Kits)(+) T cell differentiation.

  9. IRF-4-binding protein sequestered IRF-4 (show IRF4 ELISA Kits) and prevented it from targeting the transcriptional regulatory regions of the genes that encode IL-17 (show IL17A ELISA Kits) and IL-21 (show IL21 ELISA Kits).

  10. IBP/Def6 as a novel component of the TLR4 (show TLR4 ELISA Kits)-induced signaling cascade that controls the production of proinflammatory cytokines

Human Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) interaction partners

  1. IBP (show TSPO ELISA Kits) was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases

  2. DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.

  3. Molecular cloning of IBP (show TSPO ELISA Kits), a guanine nucleotide exchange factor (show RASGRF1 ELISA Kits), which is highly expressed in the immune system.

  4. IBP (show TSPO ELISA Kits) is a novel guanine nucleotide exchange factor (show RASGRF1 ELISA Kits) and is recruited to the immunological synapse by T cell receptor engagement

  5. DEF6 not only activates Rho-family GTPases but also cooperates with activated Rac1 to exert its cellular function

  6. Overexpression of the Interferon regulatory factor 4 (show IRF4 ELISA Kits)-binding protein is associated with Colorectal Carcinoma.

  7. DEF6 (show DEFA6 ELISA Kits), a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42 (show CDC42 ELISA Kits), and RhoA (show RHOA ELISA Kits).

DEF6 Antigen Profile

Antigen Summary

DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003

Gene names and symbols associated with DEF6

  • differentially expressed in FDCP 6 homolog (mouse) (DEF6) antibody
  • differentially expressed in FDCP 6a homolog (mouse) (def6a) antibody
  • differentially expressed in FDCP 6 homolog (def6) antibody
  • differentially expressed in FDCP 6 homolog (LOC100498543) antibody
  • differentially expressed in FDCP 6 (Def6) antibody
  • differentially expressed in FDCP 6 homolog (mouse) (Def6) antibody
  • 2410003F05Rik antibody
  • 6430538D02Rik antibody
  • AV094905 antibody
  • Def6 antibody
  • IBP antibody
  • MGC68775 antibody
  • SLAT antibody
  • Slat2 antibody
  • Slat6 antibody
  • SWAP70L antibody
  • zgc:63721 antibody

Protein level used designations for DEF6

differentially expressed in FDCP 6 homolog (mouse) , differentially expressed in FDCP 6 homolog , DEF-6 , IRF-4-binding protein , IRF4-binding protein , SWAP-70-like adapter of T-cells , SWAP-70-like adaptor protein of T cells

GENE ID SPECIES
419893 Gallus gallus
462636 Pan troglodytes
394015 Danio rerio
398924 Xenopus laevis
100498543 Xenopus (Silurana) tropicalis
100053351 Equus caballus
23853 Mus musculus
50619 Homo sapiens
608163 Canis lupus familiaris
100154998 Sus scrofa
516457 Bos taurus
309642 Rattus norvegicus
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