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Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. Additionally we are shipping Dihydrofolate Reductase Proteins (34) and Dihydrofolate Reductase Kits (8) and many more products for this protein.
Showing 10 out of 49 products:
Human Monoclonal Dihydrofolate Reductase Primary Antibody for IF, ELISA - ABIN560600
Ionova, Vásquez-Vivar, Whitsett, Herrnreiter, Medhora, Cooley, Pieper: Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes. in American journal of physiology. Heart and circulatory physiology 2008
Show all 6 references for ABIN560600
Dog (Canine) Monoclonal Dihydrofolate Reductase Primary Antibody for IF, IP - ABIN968118
de Wind, Dekker, Claij, Jansen, van Klink, Radman, Riggins, van der Valk, vant Wout, te Riele: HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. in Nature genetics 1999
Show all 5 references for ABIN968118
Mouse (Murine) Polyclonal Dihydrofolate Reductase Primary Antibody for EIA, WB - ABIN453196
Cody, Pace, Chisum, Rosowsky: New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring s in Proteins 2006
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Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish.
Overexpression of miR (show MLXIP Antibodies)-192 inhibited cellular proliferation by binding DHFR. miR (show MLXIP Antibodies)-192 decreased cellular anchoring via the repression of ITGAV (show ITGAV Antibodies), ITGB1 (show ITGB1 Antibodies), ITGB3 (show ITGB3 Antibodies), and CD47 (show CD47 Antibodies)
Data suggest that DHFR exhibits intrinsic activity kinetics that are temperature-independent; additional mass (i.e., incorporation of H, C, and N isotopes) has no effect on intrinsic activity kinetics or protein conformation/stability of DHFR.
patients homozygous for the G allele of rs1053129 in the DHFR gene were more likely to have a metastasis (45%, P= 0.005), and the methylenetetetrahydrofolate reductase (MTHFR (show MTHFR Antibodies)) 677C allele was associated with higher degree of liver toxicity
the association between cognitive outcomes with the 19-bp deletion DHFR polymorphism, folate status, and their interaction with high or normal plasma folate
S-nitrosylation of DHFR at cysteine 7 by eNOS (show NOS3 Antibodies)-derived NO is crucial for DHFR stability.
genetic association studies in cohort of healthy young adults in Ireland: Data suggest that a 19 bp deletion/insertion polymorphism within intron 1 of DHFR (rs70991108) is not associated with folate nutritional status in the population studied.
Dihydrofolate Reductase and Thymidylate Synthase (show TYMS Antibodies) Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation.
results for the first time suggested the DHFR 19-bp D/D genotype may confer a reduced risk of NS-CL/P and might act as a protective factor against NS-CL/P in the Iranian subjects.
Triple mutant haplotypes AIRNI (N51I+C59R+S108N) of the dhfr gene associated with pyrimethamine resistance were prevalent in Chirang district of Assam.
The human dihydrofolate reductase is relatively less stable than its E.coli counterpart.
The study reports arrested hematopoiesis and vascular relaxation defects in mice with a point mutation, Thr136Ala substitution in Dhfr.
demonstrate that dihydrofolate reductase activity is also a feature of the mitochondria in both rat and mouse but this is not due to a second enzyme
Robust and processive unfolding/degradation of some substrates with very stable protein domains, including mDHFR and titin (show TTN Antibodies)(I27) .
protects endothelial nitric oxide synthase (show NOS3 Antibodies) from uncoupling in tetrahydrobiopterin deficiency
Dhfr has a role in folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation (show HELLS Antibodies)
E2F (show E2F1 Antibodies)-responsive dihydrofolate reductase promoter regulates the balance between acetylation and methylation of histone H3 (show HIST3H3 Antibodies) lysine 9
translocation of the DHFR domain was greatly impaired when it was separated from the signal-anchor sequence
mechanical stability of mouse dihydrofolate reductase is dominated by local interactions within the protein structure
Crystal structures are reported for NADPH (show FDXR Antibodies) ternary complexes with PY1011 and mouse DHFR (mDHFR), refined to 2.2 A resolution.
Hydrogen peroxide down regulates expression in response to angiotensin Ii and underlies endothelial nitric oxide synthase (show NOS3 Antibodies) dysfunction.
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.
, dihydrofolate reductase DhfR
, Dihydrofolate reductase
, Dihydrofolate reductase 1 (active)