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Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. Additionally we are shipping Dihydrofolate Reductase Antibodies (50) and Dihydrofolate Reductase Proteins (34) and many more products for this protein.
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Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish.
Data suggest that DHFR exhibits intrinsic activity kinetics that are temperature-independent; additional mass (i.e., incorporation of H, C, and N isotopes) has no effect on intrinsic activity kinetics or protein conformation/stability of DHFR.
patients homozygous for the G allele of rs1053129 in the DHFR gene were more likely to have a metastasis (45%, P= 0.005), and the methylenetetetrahydrofolate reductase (MTHFR (show MTHFR ELISA Kits)) 677C allele was associated with higher degree of liver toxicity
the association between cognitive outcomes with the 19-bp deletion DHFR polymorphism, folate status, and their interaction with high or normal plasma folate
S-nitrosylation of DHFR at cysteine 7 by eNOS (show NOS3 ELISA Kits)-derived NO is crucial for DHFR stability.
genetic association studies in cohort of healthy young adults in Ireland: Data suggest that a 19 bp deletion/insertion polymorphism within intron 1 of DHFR (rs70991108) is not associated with folate nutritional status in the population studied.
Dihydrofolate Reductase and Thymidylate Synthase (show TYMS ELISA Kits) Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation.
results for the first time suggested the DHFR 19-bp D/D genotype may confer a reduced risk of NS-CL/P and might act as a protective factor against NS-CL/P in the Iranian subjects.
Triple mutant haplotypes AIRNI (N51I+C59R+S108N) of the dhfr gene associated with pyrimethamine resistance were prevalent in Chirang district of Assam.
The human dihydrofolate reductase is relatively less stable than its E.coli counterpart.
MTHFR (show MTHFR ELISA Kits), DHFR and ATIC (show ATIC ELISA Kits) genetic variants can be considered as pharmacogenetic markers of outcome in RA patients under MTX (show MTX1 ELISA Kits) monotherapy.
The study reports arrested hematopoiesis and vascular relaxation defects in mice with a point mutation, Thr136Ala substitution in Dhfr.
demonstrate that dihydrofolate reductase activity is also a feature of the mitochondria in both rat and mouse but this is not due to a second enzyme
Robust and processive unfolding/degradation of some substrates with very stable protein domains, including mDHFR and titin (show TTN ELISA Kits)(I27) .
protects endothelial nitric oxide synthase (show NOS3 ELISA Kits) from uncoupling in tetrahydrobiopterin deficiency
Dhfr has a role in folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation (show HELLS ELISA Kits)
E2F (show E2F1 ELISA Kits)-responsive dihydrofolate reductase promoter regulates the balance between acetylation and methylation of histone H3 (show HIST3H3 ELISA Kits) lysine 9
translocation of the DHFR domain was greatly impaired when it was separated from the signal-anchor sequence
mechanical stability of mouse dihydrofolate reductase is dominated by local interactions within the protein structure
Crystal structures are reported for NADPH (show FDXR ELISA Kits) ternary complexes with PY1011 and mouse DHFR (mDHFR), refined to 2.2 A resolution.
Hydrogen peroxide down regulates expression in response to angiotensin Ii and underlies endothelial nitric oxide synthase (show NOS3 ELISA Kits) dysfunction.
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.
, dihydrofolate reductase DhfR
, Dihydrofolate reductase
, Dihydrofolate reductase 1 (active)