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Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. Additionally we are shipping Dihydrofolate Reductase Antibodies (49) and Dihydrofolate Reductase Kits (8) and many more products for this protein.
Showing 10 out of 34 products:
Mouse (Murine) Dihydrofolate Reductase Protein expressed in Escherichia coli (E. coli) - ABIN667350
Chen, Shimada, Moulton, Cline, Humphries, Maizel, Nienhuis: The functional human dihydrofolate reductase gene. in The Journal of biological chemistry 1984
Show all 2 references for ABIN667350
Human Dihydrofolate Reductase Protein expressed in Escherichia coli (E. coli) - ABIN666887
Hu, Kireev, Plutz, Ashourian, Belmont: Large-scale chromatin structure of inducible genes: transcription on a condensed, linear template. in The Journal of cell biology 2009
Show all 2 references for ABIN666887
Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish.
Data suggest that DHFR exhibits intrinsic activity kinetics that are temperature-independent; additional mass (i.e., incorporation of H, C, and N isotopes) has no effect on intrinsic activity kinetics or protein conformation/stability of DHFR.
patients homozygous for the G allele of rs1053129 in the DHFR gene were more likely to have a metastasis (45%, P= 0.005), and the methylenetetetrahydrofolate reductase (MTHFR (show MTHFR Proteins)) 677C allele was associated with higher degree of liver toxicity
the association between cognitive outcomes with the 19-bp deletion DHFR polymorphism, folate status, and their interaction with high or normal plasma folate
S-nitrosylation of DHFR at cysteine 7 by eNOS (show NOS3 Proteins)-derived NO is crucial for DHFR stability.
genetic association studies in cohort of healthy young adults in Ireland: Data suggest that a 19 bp deletion/insertion polymorphism within intron 1 of DHFR (rs70991108) is not associated with folate nutritional status in the population studied.
Dihydrofolate Reductase and Thymidylate Synthase (show TYMS Proteins) Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation.
results for the first time suggested the DHFR 19-bp D/D genotype may confer a reduced risk of NS-CL/P and might act as a protective factor against NS-CL/P in the Iranian subjects.
Triple mutant haplotypes AIRNI (N51I+C59R+S108N) of the dhfr gene associated with pyrimethamine resistance were prevalent in Chirang district of Assam.
The human dihydrofolate reductase is relatively less stable than its E.coli counterpart.
MTHFR (show MTHFR Proteins), DHFR and ATIC (show ATIC Proteins) genetic variants can be considered as pharmacogenetic markers of outcome in RA patients under MTX (show MTX1 Proteins) monotherapy.
The study reports arrested hematopoiesis and vascular relaxation defects in mice with a point mutation, Thr136Ala substitution in Dhfr.
demonstrate that dihydrofolate reductase activity is also a feature of the mitochondria in both rat and mouse but this is not due to a second enzyme
Robust and processive unfolding/degradation of some substrates with very stable protein domains, including mDHFR and titin (show TTN Proteins)(I27) .
protects endothelial nitric oxide synthase (show NOS3 Proteins) from uncoupling in tetrahydrobiopterin deficiency
Dhfr has a role in folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation (show HELLS Proteins)
E2F (show E2F1 Proteins)-responsive dihydrofolate reductase promoter regulates the balance between acetylation and methylation of histone H3 (show HIST3H3 Proteins) lysine 9
translocation of the DHFR domain was greatly impaired when it was separated from the signal-anchor sequence
mechanical stability of mouse dihydrofolate reductase is dominated by local interactions within the protein structure
Crystal structures are reported for NADPH (show FDXR Proteins) ternary complexes with PY1011 and mouse DHFR (mDHFR), refined to 2.2 A resolution.
Hydrogen peroxide down regulates expression in response to angiotensin Ii and underlies endothelial nitric oxide synthase (show NOS3 Proteins) dysfunction.
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.
, dihydrofolate reductase DhfR
, Dihydrofolate reductase
, Dihydrofolate reductase 1 (active)