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Dihydrofolate Reductase Proteins (DHFR)

Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. Additionally we are shipping Dihydrofolate Reductase Antibodies (51) and Dihydrofolate Reductase Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DHFR 1719 P00374
DHFR 13361 P00375
DHFR 24312 Q920D2
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Top Dihydrofolate Reductase Proteins at antibodies-online.com

Showing 10 out of 34 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$273.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 2 to 3 Days
$383.25
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$242.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,442.00
Details
Yeast Mesocricetus auratus His tag   1 mg Log in to see 56 to 66 Days
$2,442.00
Details

DHFR Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Top referenced Dihydrofolate Reductase Proteins

  1. Mouse (Murine) Dihydrofolate Reductase Protein expressed in Escherichia coli (E. coli) - ABIN667350 : Chen, Shimada, Moulton, Cline, Humphries, Maizel, Nienhuis: The functional human dihydrofolate reductase gene. in The Journal of biological chemistry 1984 (PubMed)
    Show all 2 references for ABIN667350

  2. Human Dihydrofolate Reductase Protein expressed in Escherichia coli (E. coli) - ABIN666887 : Hu, Kireev, Plutz, Ashourian, Belmont: Large-scale chromatin structure of inducible genes: transcription on a condensed, linear template. in The Journal of cell biology 2009 (PubMed)
    Show all 2 references for ABIN666887

More Proteins for Dihydrofolate Reductase (DHFR) Interaction Partners

Zebrafish Dihydrofolate Reductase (DHFR) interaction partners

  1. Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish.

Human Dihydrofolate Reductase (DHFR) interaction partners

  1. the highest expression of GGH (show GGH Proteins) and EGFR (show EGFR Proteins) was noted in the left-sided colon; the highest expression of DHFR, FPGS (show FPGS Proteins), TOP1 (show TOP1 Proteins) and ERCC1 (show ERCC1 Proteins) was noted in the rectosigmoid, whereas TYMP (show TYMP Proteins) expression was approximately equivalent in the right-sided colon and rectum

  2. Overexpression of miR (show MLXIP Proteins)-192 inhibited cellular proliferation by binding DHFR. miR (show MLXIP Proteins)-192 decreased cellular anchoring via the repression of ITGAV (show ITGAV Proteins), ITGB1 (show ITGB1 Proteins), ITGB3 (show ITGB3 Proteins), and CD47 (show CD47 Proteins)

  3. Data suggest that DHFR exhibits intrinsic activity kinetics that are temperature-independent; additional mass (i.e., incorporation of H, C, and N isotopes) has no effect on intrinsic activity kinetics or protein conformation/stability of DHFR.

  4. patients homozygous for the G allele of rs1053129 in the DHFR gene were more likely to have a metastasis (45%, P= 0.005), and the methylenetetetrahydrofolate reductase (MTHFR (show MTHFR Proteins)) 677C allele was associated with higher degree of liver toxicity

  5. the association between cognitive outcomes with the 19-bp deletion DHFR polymorphism, folate status, and their interaction with high or normal plasma folate

  6. S-nitrosylation of DHFR at cysteine 7 by eNOS (show NOS3 Proteins)-derived NO is crucial for DHFR stability.

  7. genetic association studies in cohort of healthy young adults in Ireland: Data suggest that a 19 bp deletion/insertion polymorphism within intron 1 of DHFR (rs70991108) is not associated with folate nutritional status in the population studied.

  8. Dihydrofolate Reductase and Thymidylate Synthase (show TYMS Proteins) Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation.

  9. results for the first time suggested the DHFR 19-bp D/D genotype may confer a reduced risk of NS-CL/P and might act as a protective factor against NS-CL/P in the Iranian subjects.

  10. Triple mutant haplotypes AIRNI (N51I+C59R+S108N) of the dhfr gene associated with pyrimethamine resistance were prevalent in Chirang district of Assam.

Mouse (Murine) Dihydrofolate Reductase (DHFR) interaction partners

  1. The study reports arrested hematopoiesis and vascular relaxation defects in mice with a point mutation, Thr136Ala substitution in Dhfr.

  2. S-nitrosylation of DHFR at cysteine 7 by eNOS (show NOS3 Proteins)-derived NO is crucial for DHFR stability.

  3. demonstrate that dihydrofolate reductase activity is also a feature of the mitochondria in both rat and mouse but this is not due to a second enzyme

  4. Robust and processive unfolding/degradation of some substrates with very stable protein domains, including mDHFR and titin (show TTN Proteins)(I27) .

  5. protects endothelial nitric oxide synthase (show NOS3 Proteins) from uncoupling in tetrahydrobiopterin deficiency

  6. Dhfr has a role in folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation (show HELLS Proteins)

  7. E2F (show E2F1 Proteins)-responsive dihydrofolate reductase promoter regulates the balance between acetylation and methylation of histone H3 (show HIST3H3 Proteins) lysine 9

  8. translocation of the DHFR domain was greatly impaired when it was separated from the signal-anchor sequence

  9. mechanical stability of mouse dihydrofolate reductase is dominated by local interactions within the protein structure

  10. Crystal structures are reported for NADPH (show FDXR Proteins) ternary complexes with PY1011 and mouse DHFR (mDHFR), refined to 2.2 A resolution.

Cow (Bovine) Dihydrofolate Reductase (DHFR) interaction partners

  1. Hydrogen peroxide down regulates expression in response to angiotensin Ii and underlies endothelial nitric oxide synthase (show NOS3 Proteins) dysfunction.

Dihydrofolate Reductase (DHFR) Protein Profile

Protein Summary

Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.

Gene names and symbols associated with Dihydrofolate Reductase Proteins (DHFR)

  • dihydrofolate reductase (dhfr)
  • dihydrofolate reductase (DHFR)
  • dihydrofolate reductase (dhfR)
  • dihydrofolate reductase (folA)
  • dihydrofolate reductase (dfrA)
  • dihydrofolate reductase DhfR (dhfR)
  • dihydrofolate reductase (CNJ01940)
  • dihydrofolate reductase (DDB_G0286755)
  • Dihydrofolate reductase (Dhfr)
  • Dihydrofolate reductase (Mesil_0096)
  • Dihydrofolate reductase (Arch_0408)
  • dihydrofolate reductase (Fbal_3367)
  • dihydrofolate reductase (Ilyop_0482)
  • dihydrofolate reductase (Lbys_2007)
  • dihydrofolate reductase (Riean_0733)
  • Dihydrofolate reductase (Mrub_1855)
  • Dihydrofolate reductase (Poras_0766)
  • dihydrofolate reductase (Halhy_3552)
  • dihydrofolate reductase (Mesop_3614)
  • dihydrofolate reductase (Dhfr)
  • 8430436I03Rik protein
  • AA607882 protein
  • AI662710 protein
  • AW555094 protein
  • cb595 protein
  • CG14887 protein
  • DDBDRAFT_0187132 protein
  • DDBDRAFT_0230113 protein
  • DDB_0187132 protein
  • DDB_0230113 protein
  • dhfr protein
  • Dhfr1 protein
  • DHFRP1 protein
  • Dmel\\CG14887 protein
  • DYR protein
  • ECK0049 protein
  • F10_orf160 protein
  • JW0047 protein
  • tmrA protein
  • zgc:86637 protein

Protein level used designations for Dihydrofolate Reductase Proteins (DHFR)

dihydrofolate reductase , dihydrofolate reductase DhfR , CG14887-PA , CG14887-PB , Dhfr-PA , Dhfr-PB , Dihydrofolate reductase , Dihydrofolate reductase 1 (active)

GENE ID SPECIES
1055571 Citrobacter freundii
711268 Macaca mulatta
875311 Mycoplasma genitalium G37
2807610 Mycoplasma mobile 163K
876943 Mycoplasma pneumoniae M129
1488256 Saimiriine herpesvirus 2
944790 Escherichia coli str. K-12 substr. MG1655
1091594 Mycobacterium bovis AF2122/97
81882 Danio rerio
735442 Pan troglodytes
707382 Macaca mulatta
6762344 Streptococcus equi subsp. zooepidemicus MGCS10565
3254250 Cryptococcus neoformans var. neoformans JEC21
8625801 Dictyostelium discoideum AX4
42003 Drosophila melanogaster
9249572 Meiothermus silvanus DSM 9946
9260970 Arcanobacterium haemolyticum DSM 20595
9772220 Ferrimonas balearica DSM 9799
9867983 Ilyobacter polytropus DSM 2926
9955862 Leadbetterella byssophila DSM 17132
10001480 Riemerella anatipestifer ATCC 11845 = DSM 15868
8879963 Meiothermus ruber DSM 1279
10575250 Porphyromonas asaccharolytica DSM 20707
10587734 Haliscomenobacter hydrossis DSM 1100
10827453 Mesorhizobium opportunistum WSM2075
1719 Homo sapiens
609048 Canis lupus familiaris
13361 Mus musculus
24312 Rattus norvegicus
508809 Bos taurus
427317 Gallus gallus
100525912 Sus scrofa
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