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Dihydrolipoyl Transacetylase Proteins (DLAT)

DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). Additionally we are shipping Dihydrolipoyl Transacetylase Antibodies (55) and Dihydrolipoyl Transacetylase Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DLAT 1737 P10515
DLAT 81654 P08461
DLAT 235339 Q8BMF4
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Top Dihydrolipoyl Transacetylase Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$809.60
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,589.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Human Un-conjugated   2 μg Log in to see 6 Days
$168.54
Details

DLAT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for Dihydrolipoyl Transacetylase (DLAT) Interaction Partners

Human Dihydrolipoyl Transacetylase (DLAT) interaction partners

  1. ongoing activation of PDCE2-specific B-cells in primary biliary cirrhosis

  2. Results show that DLAT and ACAT2 (show ACAT2 Proteins) as upstream acetyltransferases of K76 and K294 in 6PGD (show PGD Proteins) protein.

  3. These findings were used to identify potentially antigenic sequences within PDC-E2 (an important hepatic autoantigen) that contain a DR0801 motif.

  4. Solution structure and characterisation of the human pyruvate dehydrogenase (show PDP Proteins) complex core assembly

  5. Data suggest that the catalytic site of pyruvate dehydrogenase (show PDP Proteins) complex E2 rather than the previously reported lipoyl binding peptide (show HP Proteins) may contain immunodominant epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis.

  6. a novel HLA-A*0201-restricted epitope PDC-E2 165 to 174 was defined in patients with primary biliary cirrhosis.

  7. study of facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase

  8. model of the pyruvate dehydrogenase (show PDP Proteins) complex formed by E2 and E2 plus the E3-binding protein (show PDHX Proteins) and binding of the E1 and E3 components

  9. Having found that there is an excellent and almost unique match between the PDC-E2 autoepitope and a sequence in mycobacterial hsp65s, we tested the corresponding peptides for cross-reactivity using sera from 90 Spanish and British PBC patients.

  10. This study report two unrelated patients with pyruvate dehydrogenase (show PDP Proteins) deficiency caused by defects in the E2 subunit.

Zebrafish Dihydrolipoyl Transacetylase (DLAT) interaction partners

  1. Deficiency of dihydrolipoamide S-acetyltransferase (Dlat) results in neurological dysfunction, congenital lactic acidosis, growth retardation, and early death.

Mouse (Murine) Dihydrolipoyl Transacetylase (DLAT) interaction partners

  1. breach of tolerance to PDC-E2 is probably the first event in the natural history of primary biliary cirrhosis in genetically susceptible hosts.

  2. a novel function of pyruvate dehydrogenase (show PDP Proteins) complex E2 in the nucleus in up-regulating the transactivating ability of STAT5 (show STAT5A Proteins)

Dihydrolipoyl Transacetylase (DLAT) Protein Profile

Protein Summary

This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

Gene names and symbols associated with DLAT

  • CG5261 gene product from transcript CG5261-RB (CG5261)
  • dihydrolipoamide S-acetyltransferase (dlat)
  • dihydrolipoamide S-acetyltransferase (DLAT)
  • dihydrolipoamide S-acetyltransferase (Dlat)
  • dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (dlat)
  • dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat)
  • 6332404G05Rik protein
  • anon-WO0118547.121 protein
  • DLAT protein
  • DLTA protein
  • Dmel\\CG5261 protein
  • EP(2)0816 protein
  • EP816 protein
  • PDC-E2 protein
  • PDCE2 protein
  • wu:fc14f10 protein
  • wu:fc21f08 protein
  • wu:fc86g11 protein
  • wu:fj57d06 protein

Protein level used designations for DLAT

CG5261-PA , CG5261-PB , CG5261-PC , CG5261-PD , CG5261-PE , CG5261-PF , Dihydrolipoyllysine-residue acetyltransferase , dihydrolipoamide acetyltransferase , dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) , 70 kDa mitochondrial autoantigen of primary biliary cirrhosis , E2 component of pyruvate dehydrogenase complex , M2 antigen complex 70 kDa subunit , PBC , dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex , dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial , dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial , pyruvate dehydrogenase complex component E2 , dihydrolipoyllysine-residue acetyltransferase , E2 , PDC-E2 , PDCE2 , fc86g11 , fj57d06 , no optokinetic nystagmus a , no optokinetic response b , noa , nrb

GENE ID SPECIES
34021 Drosophila melanogaster
398314 Xenopus laevis
419796 Gallus gallus
1737 Homo sapiens
489406 Canis lupus familiaris
397054 Sus scrofa
512723 Bos taurus
81654 Rattus norvegicus
100349212 Oryctolagus cuniculus
324201 Danio rerio
235339 Mus musculus
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