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Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Additionally we are shipping DPYSL3 Antibodies (85) and DPYSL3 Kits (5) and many more products for this protein.
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Data indicate that CRMP4a and CRMP4b isoforms have opposite effects on cell proliferation, migration, and invasion in gastric cancer. CRMP4a expression was reduced in gastric carcinoma tissues and cell lines and seems to act as a tumor suppressor in gastric carcinoma. CRMP4b expression was higher in tumor tissue and cell lines.
DPYSL3 expression levels inversely correlated with those of VEGF (show VEGFA Proteins) and FAK (show PTK2 Proteins). Down-regulation of DPYSL3 expression in HCC (show FAM126A Proteins) tissues may serve as a predictive biomarker for HCC (show FAM126A Proteins) after curative resection.
Expression status of DPYSL3 in gastric cancer tissues may represent a promising biomarker for the malignant behavior of GC.
DPYSL3 as pancreatic ductal adenocarcinoma-associated (show EPCAM Proteins) molecule that regulates cell adhesion and migration by stabilization of focal adhesion complex
structures provide further insight into the effects of medically relevant mutations of the DPYSL-3 gene encoding CRMP-4 and the putative enzymatic activities of CRMPs
High collapsin response mediator protein 4 expression is associated with liver metastasis in pancreatic cancer.
Downregulation of MYCN (show MYCN Proteins) by small interfering RNA (siRNA) increased DPYSL3 levels, while upregulation of MYCN (show MYCN Proteins) in non-MYCN (show MYCN Proteins) NB cells decreased DPYSL3 levels.
study found the association between the rs147541241 variant and amyotrophic lateral scerosis was limited to the French population
Ulip1 was downregulated and HIF1a (show HIF1A Proteins) was upregulated in hypoxic neuroblastoma (show ARHGEF16 Proteins) cells.
CRMP4 is a key physiological substrate of GSK3 in regulating chromosomal alignment and mitotic progression through its effect on spindle microtubules
Results indicate that CRMP1 (show CRMP1 Proteins) and CRMP4 regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex during development.
CRMP4-deficient mice show reduced inflammation and suppressed dopaminergic neuronal death in a model of Parkinson's disease.
our data suggest that disruption of CRMP4 produces a temporary alteration in the thickness of the external of the olfactory bulb, which is constituted mainly of mitral cell apical dendrites, through the enhanced growth of these dendrites
These results suggest that deletion of CRMP4 is a unique therapeutic strategy that overcomes two obstacles to CNS repair after SCI.
CRMP4 inhibits prostate cancer cells growth in the nude mouse bone microenvironment.
This study identified a dual role for CRMP4 in regulating the actin and microtubule growth cone cytoskeleton.
In the human ortholog of Dpysl3, the association between the rs147541241 variant and amyotrophic lateral sclerosis was limited to the French population.
CRMP4 regulates the number of tyrosine hydroxylase (show TH Proteins) immunoreactive neurons in the female anteroventral periventricular nucleus.
Results suggest that CRMP4 suppresses apical dendrite bifurcation of CA1 (show CA1 Proteins) pyramidal neurons in the mouse hippocampus and that this is partly dependent on Sema3A (show SEMA3A Proteins) signaling.
MAG-mediated axon protection against VNC is suppressed in CRMP4-/- DRG neurons.
phosphorylation of Dpysl2 (show DPYSL2 Proteins) and Dpysl3 by Cyclin-dependent kinase 5 (show CDK5 Proteins) and dual-specificity tyrosine-phosphorylated and regulated kinase 2 is required for correct positioning of CaP motor neurons in the zebrafish spinal cord
These results suggest that the phosphorylation of Dpysl2 (show DPYSL2 Proteins) and Dpysl3 by Cdk5 (show CDK5 Proteins) and DYRK2 (show DYRK2 Proteins) is required for the proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish embryos.
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
collapsin response mediator protein-4A
, collapsin response mediator protein-4B
, dihydropyrimidinase-related protein 3
, dihydropyrimidinase-like 3
, Dihydropyrimidinase-related protein 3
, hypothetical protein LOC494650
, Collapsin response mediator protein 4
, collapsin response mediator protein 4 long-like
, collapsin response mediator protein 4 long
, unc-33-like phosphoprotein 1
, collapsin response mediator protein 4
, TOAD-64/Ulip/CRMP protein 4b
, dihydropyrimidinase-related protein 3-A
, neural-specific protein 1