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Disabled Homolog 1 (Drosophila) Proteins (DAB1)

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. Additionally we are shipping DAB1 Antibodies (127) and DAB1 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DAB1 1600 O75553
DAB1 266729 Q8CJH2
DAB1 13131 P97318
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Top DAB1 Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

DAB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Rat (Rattus)

Mouse (Murine)

More Proteins for Disabled Homolog 1 (Drosophila) (DAB1) Interaction Partners

Zebrafish Disabled Homolog 1 (Drosophila) (DAB1) interaction partners

  1. Alternatively spliced dab1 isoforms were identified.

Human Disabled Homolog 1 (Drosophila) (DAB1) interaction partners

  1. Study shows that early neural cells transiently express Reelin (show RELN Proteins) at the time they leave the presumptive olfactory/vomeronasal epithelium and that Dab 1 is present in the migratory cell mass and in the presumptive ensheathing cells in the absence of reelin (show RELN Proteins).

  2. this study is the first to provide genetic evidence for DAB1 as a candidate AD liability/protection gene, although the strength of the contribution of DAB1 may differ among populations

  3. results of this study demonstrated the presence of reelin (show RELN Proteins), its receptors VLDLR (show VLDLR Proteins) and ApoER2 (show LRP8 Proteins) as well as Dab1 in the ENS and might indicate a novel role of the reelin (show RELN Proteins) system in regulating neuronal plasticity and pre-synaptic functions in the ENS.

  4. The finding of this study suggested that variations in DAB1 involved in the Reelin signaling pathway might contribute to genetic susceptibility to autism with Chinese Han decent.

  5. Variation in genes encoding proteins at the gateway of Reelin (show RELN Proteins) signaling: ligands RELN (show RELN Proteins) and APOE (show APOE Proteins), their common receptors APOER2 (show LRP8 Proteins) and VLDLR (show VLDLR Proteins), and adaptor DAB1, was examined.

  6. show that Reelin (show RELN Proteins)-stimulated Notch-1 (show NOTCH1 Proteins) activation is dependent on Reelin (show RELN Proteins) signaling

  7. alternative splicing of Dab1 is conserved in avian and mammalian species, with Dab1-L driving SFK phosphorylation in both species

  8. we report for the first time, that DAB1 is significantly up-regulated in human frontal cortex brain samples of Alzheimer disease patients

  9. Dab1, an essential component of the reelin (show RELN Proteins) pathway, is required for glia-independent somal translocation in the neocortex.

  10. Fe65 (show APBB1 Proteins) and Dab1 compete for binding to APP (show APP Proteins). Dab1 significantly decreased the amount of APP (show APP Proteins) bound to LRP (show RPSA Proteins) and the level of secreted APP (show APP Proteins) and APP (show APP Proteins)-CTF (show NFIA Proteins) in LRP (show RPSA Proteins) expressing cells

Mouse (Murine) Disabled Homolog 1 (Drosophila) (DAB1) interaction partners

  1. This study showed that spontaneous Dab1 mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.

  2. an aberrant fragment of Dab1 protein (p64 (show IL2RG Proteins)/60) is present in the brain of yotari mouse

  3. When pregnant mice are exposed to EMF, Dab1 expression increases in the EMF-treated fetal cerebral cortex extracts as compared to controls and SHAM group.

  4. It findings link reelin (show RELN Proteins) with Dab1 and suggest that Dab1 functions downstream of reelin (show RELN Proteins) action on the homeostasis of the crypt-villus unit.

  5. The results of this study indicate a causal relation between the downregulation of Dab1 protein levels during development and the structural and behavioral deficits associated with psychiatric diseases in the adult.

  6. The expression of Dab-1 was analyzed in the developing mouse autopod. Transcripts of Dab-1 were abundant in the autopodial tendon primordia, but transcripts were also present in the undifferentiated mesoderm located around the digits.

  7. results suggest a major role of VEGF in the regulation of reelin signaling, and Dab1 as a key molecule in the cross talk between reelin and VEGF signaling pathways.

  8. Dab1 is specifically knocked out in immature neurons while it remains active in glial cells.

  9. Dab1 mediated the association of CIN85 (show SH3KBP1 Proteins) with ApoER2 (show LRP8 Proteins) or VLDLR (show VLDLR Proteins) in neurons.

  10. Dab1 is a critical regulator of synaptic function and hippocampal-dependent associative and spatial learning.

Pig (Porcine) Disabled Homolog 1 (Drosophila) (DAB1) interaction partners

  1. Alternative spliced forms of disabled homolog 1 (DAB1) have been isolated from brain and liver.

DAB1 Protein Profile

Protein Summary

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

Gene names and symbols associated with DAB1

  • disabled homolog 1 (Drosophila) (DAB1)
  • disabled homolog 1 (LOC100232823)
  • disabled homolog 1 (Drosophila) (dab1)
  • Dab, reelin signal transducer, homolog 1 (Drosophila) (DAB1)
  • Dab, reelin signal transducer, homolog 1 (Drosophila) (Dab1)
  • disabled 1 (Dab1)
  • AI956902 protein
  • C630028C02Rik protein
  • DAB1 protein
  • disabled-1 protein
  • LOC100232823 protein
  • scm protein
  • scr protein
  • scrambler protein
  • si:dkey-242m13.1 protein
  • yot protein

Protein level used designations for DAB1

disabled homolog 1 , disabled1 , disabled homolog 1 (Drosophila) , DAB1 variant protein-like , disabled homolog 1-like , yotari

100049825 Equus caballus
100232823 Taeniopygia guttata
692351 Danio rerio
740508 Pan troglodytes
100337993 Oryctolagus cuniculus
100453388 Pongo abelii
100583389 Nomascus leucogenys
1600 Homo sapiens
266729 Rattus norvegicus
538818 Bos taurus
13131 Mus musculus
374083 Gallus gallus
610344 Canis lupus familiaris
100037307 Sus scrofa
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