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DAB2 encodes a mitogen-responsive phosphoprotein. Additionally we are shipping DAB2 Antibodies (86) and DAB2 Proteins (7) and many more products for this protein.
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Data show that miR106b was frequently up-regulated in human cervical carcinoma tumors and cell lines and inversely correlated with DAB2 expression. Its regulation in under TGF-beta1 (show TGFB1 ELISA Kits) which contributes to cell migration by targeting DAB2 in cervical carcinoma.
these findings reveal that DAB2 is critical for controlling inflammatory signaling during phenotypic polarization of macrophages
inhibition of WNT (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling by DAB2 is essential for establishing the correct number of cardiomyocytes in the developing heart.
DAB2 regulated the cell migration associated genes in PC3 (show PCSK1 ELISA Kits) cells, and the differential DAB2 expression between LNCaP and PC3 (show PCSK1 ELISA Kits) cells was partly regulated by histone 4 acetylation.
Dab2 depletion also increases the rescued protein half-life of DeltaF508 CFTR (show CFTR ELISA Kits) by ~18% and ~91%, respectively
These results indicated that miR (show MLXIP ELISA Kits)-93 plays an important role in the initiation and progression of NPC (show NPC1 ELISA Kits) by targeting Dab2 and the miR (show MLXIP ELISA Kits)-93/Dab2 pathway may contribute to the development of novel therapeutic strategies for NPC (show NPC1 ELISA Kits) in the future.
DAB2 expression is decreased in Non-Small Cell Lung Cancer , and the frequent methylation event at sites -86 to 226 of the DAB2 gene could contribute to the downregulation of DAB2.
Attenuating Dab2 expression in K562 cells diminished TfR (show TFRC ELISA Kits) internalization and increased surface levels of TfR (show TFRC ELISA Kits) concomitantly with a decrease in Tf uptake and erythroid differentiation.
Results suggest that endogenous Dab2 exacerbates central nervous system inflammation, potentially acting to up-regulate reactive oxygen species expression in macrophages and microglia, and that it is of potential pathogenic relevance in multiple sclerosis
Numb (show NUMB ELISA Kits) specifically regulates NPC1L1 (show NPC1L1 ELISA Kits)-mediated cholesterol absorption both in human intestine and liver, distinct from ARH (show LDLRAP1 ELISA Kits) and Dab2, which selectively participate in LDLR (show LDLR ELISA Kits)-mediated LDL uptake.
Results identified a novel activation marker, DAB2, which expression is significantly different between microglia activation stages M2a and either M1 or M2b.
Dab2 expression is induced by hormones
Disabled-2 is required for efficient hemostasis and platelet activation by thrombin (show F2 ELISA Kits) in mice.
Akt1 (show AKT1 ELISA Kits) and Akt2 (show AKT2 ELISA Kits) are involved in albumin (show ALB ELISA Kits) endocytosis, and phosphorylation of Dab2 by Akt (show AKT1 ELISA Kits) induces albumin (show ALB ELISA Kits) endocytosis in proximal tubule epithelial cells.
Study of dab2 mutant allele in embryos and embryoid bodies confirms a role for Dab2 in extraembryonic endoderm development and epithelial organization. Also, Dab2 has a physiological role in the endocytosis of lipoproteins and cholesterol metabolism.
miR (show MLXIP ELISA Kits)-145 regulates the migration and invasion of highly invasive prostate cancer cells through targeting DAB2 gene
The authors report that Dab2, previously described as an inhibitor of Wnt/beta-catenin signalling, selectively recruits LRP6 to the clathrin-dependent endocytic route, thereby sequestering it from caveolin-mediated endocytosis.
Data show that although small RNA-mediated Dab2 knockdown had no affect on the internalization of various clathrin-dependent cargo, TGF-beta (show TGFB1 ELISA Kits) receptor recycling was abrogated.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 ELISA Kits) and PTGS2 (show PTGS2 ELISA Kits), and decreased the expression of SOD2 (show SOD2 ELISA Kits), GPX3 (show GPX3 ELISA Kits), DAB2, and NR3C1 (show NR3C1 ELISA Kits). TNF (show TNF ELISA Kits) and IL6 (show IL6 ELISA Kits) levels were also decreased while those of NAMPT (show NAMPT ELISA Kits) were unaffected.
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
, disabled homolog 2
, disabled homolog 2, mitogen-responsive phosphoprotein
, disabled homolog 2-like
, differentially-expressed protein 2
, mitogen-responsive phosphoprotein
, DOC-2 p82 isoform
, disabled homolog 2 mitogen-responsive phosphoprotein