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DLG2 encodes a member of the membrane-associated guanylate kinase (MAGUK) family. Additionally we are shipping DLG2 Antibodies (92) and many more products for this protein.
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Two novel promoters and coding first exons in the DLG2 gene were identified. These novel isoforms are expressed in the fetal brain. Deletions of these new elements were found associated with neurodevelopmental disorders. The work brings evidence for the lack of cross-annotation in human versus mouse reference genomes and nucleotide versus protein databases.
DLG2 - novel candidate genes validated in a large case-control sample of schizophrenia.
The PDZ1 domain of PSD-93 might accept peptides with larger residues at the C-terminus than that of PSD-95 (show DLG4 Proteins), for example the GluD2 (show GLUD2 Proteins) C-terminal Ile versus the Val found at the C-terminus of NMDA receptors.
This study showed that DLG2 is related the complex learning.
Comparison of the structures of the binding cleft of PSD-93 PDZ1 with the previously reported structures of PSD-93 PDZ2 and PDZ3 as well as of the closely related human PSD-95 (show DLG4 Proteins) PDZ1 shows that they are very similar in terms of amino-acid composition
Variation at the DLG2 locus contributes to maintenance of glucose homeostasis through regulation of insulin (show INS Proteins) sensitivity and beta-cell function.
Coexpression of Kir2.1 (show KCNJ2 Proteins) and PSD (show PSD Proteins)-93delta had no discernible effect upon channel kinetics but resulted in cell surface Kir2.1 (show KCNJ2 Proteins) clustering and suppression of channel internalization.
identifies new isoform of DLG2 gene, which contains 3'-end exons of the known DLG2 gene along with the hypothetical gene FLJ37266; new isoform is specifically upregulated in renal oncocytoma
New DLG2 gene models for human and mouse. The work brings evidence for the lack of cross-annotation in human versus mouse reference genomes and nucleotide versus protein databases.
PSD-93 knockout led to downregulation of Cox-2 and iNOS (show NOS2 Proteins) expression, and increase in the mRNA levels of IL-10 (show IL10 Proteins) following ischemic brain injury.
This study identified four proteins SynGAP (show SYNGAP1 Proteins), Syntaxin-1A (show STX1A Proteins), VDLC, and PKCbeta differentially expressed between PSD-93 KO and WT mice 4 h after tMCAO
Downregulation of nAChR (show CHRNA4 Proteins) subunit and PSD-93 expression after cavernous nerve injury, or even manipulation, could interrupt synaptic transmission within the MPG (show MPG Proteins) and thus contribute to the loss of neural control of urogenital organs after pelvic surgeries.
Membrane-associated guanylate kinase (show GUK1 Proteins) homolog PSD-93 is a central organizer of the postsynaptic density at excitatory synapses on pyramidal neurons.
These data show critical roles for psd-93 and interactions with NMDA receptor subunits in organizing the differential expression in rafts and postsynaptic densities of synaptic signaling complexes.
Since NMDARs, Ca(2 (show CA2 Proteins)+), and NO play a critical role during the development of brain trauma, seizures, and ischemia, the present work suggests that PSD-93 might contribute to molecular mechanisms of neuronal damage in these brain disorders.
PSD-93 deficiency in knock-out mice results in a decrease in the minimum alveolar anesthetic concentration of halothane (show RYR1 Proteins).
PSD-93 serves as a membrane-anchored substrate of Fyn (show FYN Proteins) and plays a role in the regulation of Fyn (show FYN Proteins)-mediated modification of NMDA receptor function
PSD93 containing complexes regulates synaptic stability at neuronal cholinergic synapses.
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known.
, disks large homolog 2
, postsynaptic density protein 93
, channel-associated protein of synapse-110
, channel-associated protein of synapses, 110kDa
, discs, large homolog 2, chapsyn-110
, postsynaptic density protein PSD-93
, protein phosphatase 1, regulatory subunit 58
, discs large homolog 2
, synaptic density protein PSD-93