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DLG3 encodes a member of the membrane-associated guanylate kinase protein family. Additionally we are shipping DLG3 Proteins (9) and DLG3 Kits (2) and many more products for this protein.
Showing 10 out of 103 products:
Mammalian Monoclonal DLG3 Primary Antibody for ISt, IHC - ABIN1304941
Williams, Featherstone: Regulation of hippocampal synaptic strength by glial xCT. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Show all 27 Pubmed References
Human Polyclonal DLG3 Primary Antibody for ICC, WB - ABIN1742274
Ludford-Menting, Oliaro, Sacirbegovic, Cheah, Pedersen, Thomas, Pasam, Iazzolino, Dow, Waterhouse, Murphy, Ellis, Smyth, Kershaw, Darcy, Humbert, Russell: A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation. in Immunity 2005
Show all 6 Pubmed References
Mouse (Murine) Polyclonal DLG3 Primary Antibody for ICC, IP - ABIN2690526
Fujita-Jimbo, Tanabe, Yu, Kojima, Mori, Li, Iwamoto, Yamagata, Momoi, Momoi: The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis. in Molecular autism 2015
Rat (Rattus) Monoclonal DLG3 Primary Antibody for ICC, IF - ABIN447355
Lecointre, Vézier, Bénard, Ramdani, Dupré, Brasse-Lagnel, Henry, Roy, Marret, Gonzalez, Jégou, Leroux-Nicollet: Age-dependent alterations of the NMDA receptor developmental profile and adult behavior in postnatally ketamine-treated mice. in Developmental neurobiology 2015
Human Polyclonal DLG3 Primary Antibody for ICC, IF - ABIN4351980
Qu, Aronica, Boer, Fällmar, Kumlien, Nistér, Wester, Pontén, Smits: DLG3/SAP102 protein expression in malformations of cortical development: a study of human epileptic cortex by tissue microarray. in Epilepsy research 2009
Cow (Bovine) Polyclonal DLG3 Primary Antibody for WB - ABIN2781528
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
Following the critical period NMDA receptor function was unaffected by loss of SAP102 but there was a reduction in the divergence of TC connectivity. These data suggest that changes in synaptic function early in development caused by mutations in SAP102 result in changes in network connectivity later in life.
Insertion of a guanine into the DLG3 5' UTR (show UTS2R Antibodies), 7 bp upstream of the start codon, down regulated DLG3 protein levels. This non-coding variant segregates with X-linked intellectual disability in a large family.
Trans-homophilic interaction of CADM1 (show CADM1 Antibodies) activates PI3K (show PIK3CA Antibodies) by forming a complex with MAGuK-family proteins MPP3 (show MPP3 Antibodies) and Dlg (show DLG4 Antibodies).
miR (show MLXIP Antibodies)-1246 might play a role in neurological pathogenesis of human enterovirus 71 by regulating DLG3 gene in infected cells.
These data shed new light on the role of SAP102 in the regulation of NMDAR (show GRIN1 Antibodies) trafficking.
This study identified DLG3 significantly associated loci with a biologically plausible role in schizophrenia.
The data of this study suggested that DLG3 is down-regulated in this cancer type.
The PDZ (show INADL Antibodies)-independent interaction between SAP102 and GluN2B (show GRIN2B Antibodies) mediates the synaptic clearance of GluN2B (show GRIN2B Antibodies)-containing NMDARs.(SAP102 protein)
Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin (show NBEA Antibodies).
DLG3 was identified by genome-wide gene expression analyses as correlated with cellular sensitivity to cisplatin and carboplatin. DLG3 was also found to correlate with cellular sensitivity to platinating agents in NCI-60 cancer cell lines.
our current study identified a functional interplay between PSD-95 (show DLG4 Antibodies) and synapse-associated protein 102 (SAP102) to regulate synaptic AMPA (show GRIA3 Antibodies) receptors
SAP102 has a fundamental role in trafficking the NMDA receptor complex to the synaptic sites.
The Dlg3 have functions in complex cognitive processes.
Dlg3 exerts a distinct function by recruiting the ubiquitin ligases Nedd4 and Nedd4-2 (show NEDD4L Antibodies) through its PPxY motifs. These interactions are required for Dlg3 monoubiquitination, apical membrane recruitment, and tight junction consolidation.
Membrane-associated guanylate kinase (show GUK1 Antibodies) homolog SAP102 is a central organizers of the postsynaptic density at excitatory synapses on pyramidal neurons.
SAP102 interacts with the PDZ (show INADL Antibodies)-binding domain of Sec8 (show EXOC4 Antibodies), a member of the exocyst complex. nteractions between the two proteins are involved in the delivery of N-methyl-D-aspartate receptors to the cell surface in heterologous cells and neurons.
SAP102 was required for normal spatial learning. Loss of SAP102 results in changes in spatial strategy usage. Altered long term potentiation and spike-timing-dependent plasticity in SAP102 mutants. Couples NMDA receptors to MAPK/ERK (show MAPK1 Antibodies) pathway.
Results describe E-dlg (show DLG4 Antibodies), a mouse homologue of the Drosophila discs large (show DLG4 Antibodies) tumor suppressor (show LATS1 Antibodies) (Dlg (show DLG4 Antibodies), also known as SAP97 (show DLG1 Antibodies)), that binds preferentially to SAP102.
This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described.
PSD-95/SAP90-related protein 1
, discs large homolog 3
, disks large homolog 3
, synapse-associated protein 102
, discs, large homolog 3 (neuroendocrine-dlg, Drosophila)
, membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)