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DLG5 encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. Additionally we are shipping and many more products for this protein.
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Depletion of Dlg5 expression by knockdown promoted the expression of the mesenchymal marker proteins, fibronectin (show FN1 Antibodies) and alpha-smooth muscle actin (show ACTG2 Antibodies), and suppressed the expression of E-cadherin (show CDH1 Antibodies).
These data suggest that inhibition of Dlg5 by DNA hypermethylation contributes to provoke invasive phenotypes in bladder tumor.
Findings demonstrate that Dlg5 interacts with and inhibits the activity of Girdin (show CCDC88A Antibodies), thereby suppressing the migration of prostate cancer cells.
DLG5 plays a role in cell migration, cell adhesion, precursor cell division, cell proliferation, epithelial cell polarity maintenance, and transmission of extracellular signals to the membrane and cytoskeleton.
Overexpression of Dlg5 enhances the degradation of TGFBRI.
Polymorphisms in the DLG5 gene were found to be associated with Crohn's disease patients in Malaysia.
Examined the genetic association of DLG5 SNP P1371Q with inflammatory bowel disease and its interaction with R30Q in disease susceptibility. P1371Q is complementary to R30Q, with R30Q exhibiting a dominant effect in IBD susceptibility.
Increased expression of discs large homolog 5 gene (show GPD1 Antibodies) is associated with ulcerative colitis.
In the studied population, DLG5 R30Q was associated with all forms of IBD. An elevated presence of the R30Q variant was observed in all members of a familial IBD registry
findings suggest that lp-dlg/KIAA0583 is a novel scaffolding protein that can link the vinexin (show Sorbs3 Antibodies)-vinculin (show VCL Antibodies) complex and beta-catenin (show CTNNB1 Antibodies) at sites of cell-cell contact
Genetic variation in DLG5 is associated with inflammatory bowel disease
Dlg5 is required for Hh-induced enrichment of Kif7 (show KIF7 Antibodies) and Gli2 (show GLI2 Antibodies) at the tip of the cilium but is dispensable for Gpr161 (show GPR161 Antibodies) exit from the cilium and the consequent suppression of Gli3 (show GLI3 Antibodies) processing into its repressor form
DLG5 is a MAGUK protein that regulates spine formation, synaptogenesis, and synaptic transmission in cortical neurons.
Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis.
Data report that Discs large (show DLG4 Antibodies) 5 (Dlg5), a member of the MAGUK family, is an interactor of CitK required for CitK polarization.
This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined.
discs, large homolog 5 (Drosophila)
, discs large homolog 5
, discs large protein
, discs, large homolog 5
, disks large homolog 5
, discs large protein LP-DLG
, discs large protein P-dlg
, large type of P-DLG
, placenta and prostate DLG