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DVL2 encodes a member of the dishevelled (dsh) protein family. Additionally we are shipping DVL2 Proteins (2) and many more products for this protein.
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The secreted frizzled-related protein (show SFRP2 Antibodies) and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.
In pancreatic cancer cells, AF6 (show MLLT4 Antibodies) is expressed at reduced levels, causing Dvl2 to be upregulated and available to bind and enhance FOXE1 (show FOXE1 Antibodies)-induced trans-activation of Snail (show SNAI1 Antibodies), which promotes proliferation and metastasis.
Epsins are required for Dishevelled stability and Wnt (show WNT2 Antibodies) signalling activation in colon cancer development.
The data suggest that the expression of DVL2 in colon tissue segments may be important in the pathogenesis of HSCR (show EDNRB Antibodies).
Elevated DVL2 expression is associated with drug resistance in colorectal cancer.
Dpr1 (show DACT1 Antibodies) promotes the ubiquitination of Dvl2 by pVHL (show VHL Antibodies) and mediates the protein aggregate-elicited autophagy initiation
The interaction of Dvl2 with Dapper-1 (show DACT1 Antibodies) is involved in the negative regulation of Wnt (show WNT2 Antibodies) signaling.
APPL1 (show APPL1 Antibodies) is a positive regulator of Dvl2-dependent transcriptional activity of AP-1 (show FOSB Antibodies).
High expression of IGFBP7 (show IGFBP7 Antibodies) in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-beta (show TGFB1 Antibodies) and Wnt (show WNT2 Antibodies) signaling in a Smad2 (show SMAD2 Antibodies)/3-Dvl2/3-dependent manner.
these results indicate that RNF185 (show RNF185 Antibodies) negatively regulates osteogenesis through the degradation of Dvl2 and down-regulation of canonical Wnt (show WNT2 Antibodies) signaling pathway and suggest a possible therapeutic target in osteoporosis.
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
dishevelled 2 (homologous to Drosophila dsh)
, dishevelled, dsh homolog 2
, segment polarity protein dishevelled homolog DVL-2