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Dishevelled, Dsh Homolog 2 Proteins (DVL2)

DVL2 encodes a member of the dishevelled (dsh) protein family. Additionally we are shipping DVL2 Antibodies (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DVL2 1856 O14641
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Top DVL2 Proteins at

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days

DVL2 Proteins by Origin and Source

Origin Expressed in Conjugate

More Proteins for Dishevelled, Dsh Homolog 2 (DVL2) Interaction Partners

Human Dishevelled, Dsh Homolog 2 (DVL2) interaction partners

  1. In pancreatic cancer cells, AF6 is expressed at reduced levels, causing Dvl2 to be upregulated and available to bind and enhance FOXE1 (show FOXE1 Proteins)-induced trans-activation of Snail (show SNAI1 Proteins), which promotes proliferation and metastasis.

  2. Epsins are required for Dishevelled stability and Wnt (show WNT2 Proteins) signalling activation in colon cancer development.

  3. The data suggest that the expression of DVL2 in colon tissue segments may be important in the pathogenesis of HSCR (show EDNRB Proteins).

  4. Elevated DVL2 expression is associated with drug resistance in colorectal cancer.

  5. Dpr1 (show DACT1 Proteins) promotes the ubiquitination of Dvl2 by pVHL (show VHL Proteins) and mediates the protein aggregate-elicited autophagy initiation

  6. The interaction of Dvl2 with Dapper-1 (show DACT1 Proteins) is involved in the negative regulation of Wnt (show WNT2 Proteins) signaling.

  7. APPL1 (show APPL1 Proteins) is a positive regulator of Dvl2-dependent transcriptional activity of AP-1 (show FOSB Proteins).

  8. High expression of IGFBP7 (show IGFBP7 Proteins) in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-beta (show TGFB1 Proteins) and Wnt (show WNT2 Proteins) signaling in a Smad2 (show SMAD2 Proteins)/3-Dvl2/3-dependent manner.

  9. these results indicate that RNF185 (show RNF185 Proteins) negatively regulates osteogenesis through the degradation of Dvl2 and down-regulation of canonical Wnt (show WNT2 Proteins) signaling pathway and suggest a possible therapeutic target in osteoporosis.

  10. IRS1 (show IRS1 Proteins)/2 promotes EMT (show ITK Proteins) and cell proliferation through stabilizing Dvl2.

DVL2 Protein Profile

Protein Summary

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.

Gene names and symbols associated with DVL2

  • dishevelled segment polarity protein 2 (DVL2)

Protein level used designations for DVL2

dishevelled 2 (homologous to Drosophila dsh) , dishevelled, dsh homolog 2 , segment polarity protein dishevelled homolog DVL-2

1856 Homo sapiens
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