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DVL3 is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. Additionally we are shipping DVL3 Proteins (2) and many more products for this protein.
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Studied and identified candidate biomarkers of biochemical recurrence (BCR (show BCR Antibodies)) of prostate adenocarcinoma by integrating reverse-phase protein array (RPPA) and mRNA datafrom The Cancer Genome Atlas (TCGA). Found DVL3 was expressed in patients with a higher risk of BCR (show BCR Antibodies). DVL3 may be a novel and easily applicable recurrence predictor of localised prostate adenocarcinoma.
two mutually exclusive functions of the DEP (show ZDHHC21 Antibodies) domain in Wnt (show WNT2 Antibodies) signal transduction - binding to Frizzled to recruit Dishevelled (show DVL2 Antibodies) to the receptor complex, is reported.
Genetic changes between MLH1 (show MLH1 Antibodies) and MSH2 (show MSH2 Antibodies) were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 (show MSH2 Antibodies) and DVL3 genes (p = 0.034).
Data show that dishevelled (show DVL2 Antibodies) proteins DVL1 (show DVL1 Antibodies), 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).
Kif26b (show KIF26B Antibodies), together with Dvl3/Daam1 (show DAAM1 Antibodies), initiates cell polarity through the control of planar cell polarity-signaling pathway-dependent activation in endothelial cells.
DVL3 transcripts decreased in individuals with major depressive disorder
we demonstrate that normally ALFY (show WDFY3 Antibodies) attenuates the canonical Wnt (show WNT2 Antibodies) signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 (show DVL1 Antibodies) or Dvl2 (show DVL2 Antibodies).
All variants in DVL3 result in a -1 frameshift, indicating that these highly specific alterations might be a common cause of dominant Robinow syndrome.
data suggest that miR (show MLXIP Antibodies)-204-5p regulates adipogenesis by controlling DVL3 expression and subsequently inhibiting the activation of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.
findings confirm that p38 (show CRK Antibodies) and PAX2 (show PAX2 Antibodies) are important for the Dvl-3 induced upregulation of p120ctn (show CTNND1 Antibodies)
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.
DSH homolog 3
, dishevelled 3 (homologous to Drosophila dsh)
, dishevelled, dsh homolog 3
, segment polarity protein dishevelled homolog DVL-3