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DISC1 encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. Additionally we are shipping DISC1 Antibodies (166) and DISC1 Kits (3) and many more products for this protein.
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A Disc1 peptide binds to GSK3beta, and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin-mediated Wnt signaling and inhibiting GSK3beta activity.
Disc1 and nrg1 (show NRG1 Proteins) function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 Proteins)-expressing precursor cells.
Disc1 functions in the transcriptional repression of foxd3 (show FOXD3 Proteins) and sox10 (show SOX10 Proteins), thus mediating cranial neural crest cell migration and differentiation.
Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Proteins) activity via DISC1.
Results suggest that DISC1 interacts with BA (show APP Proteins)CE1 and promotes lysosomal degradation of (show APP Proteins) BAC (show PSEN1 Proteins)E1, thus reducing the generation of Abeta
It is anterogradely transported to the neurite tips, together with Lis1, and functions in neurite extension via suppression of GSK3beta activity.
DISC1 disruption affects expression of neural cell fate markers and Wnt (show WNT2 Proteins) signaling.
These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.
DISC1 gene variations may affect the course of cognitive deficits found in patients suffering from the first episode of non-affective psychosis
DISC1 acts as an important regulator of mitochondrial dynamics in both axons and dendrites.
An association was found with DISC1 genetic variants and susceptibility to schizophrenia in a Han Chinese population.
Results indicate that the neurexin (show NRXN1 Proteins) and neuroligin synaptic complex is intrinsically involved in the regulation of DISC1 function, thus contributing to a better understanding of the pathology of schizophrenia.
Results with immature neurons from patients with schizophrenia and bipolar disorder showed common alterations in DISC1 levels and its cellular distribution, cAMP homeostasis, and cell migration
Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function.
Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Proteins) activity via Disc1.
Results indicate that DISC1 attenuates Abeta (show APP Proteins) generation and cognitive deficits of APP (show APP Proteins)/PS1 (show PSEN1 Proteins) transgenic mice through promoting lysosomal degradation of BACE1 (show BACE Proteins)
These results suggest that alteration of CB1R (show CNR1 Proteins)-mediated signaling in DN-DISC1 mice may underlie susceptibility to detrimental effects of adolescent cannabis exposure on adult behaviors.
These results suggest a mechanism by which cross-talk between DISC1 and NRG1 (show NRG1 Proteins)-ErbB4 (show ERBB4 Proteins) signalling may contribute to these deficits.
Study found that DISC1 influences APP (show APP Proteins) C-terminal processing and Abeta (show APP Proteins) peptide generation, affects surface expression and internalization of APP (show APP Proteins) in neurons
DISC1 regulates the expression of brain neurotrophin (show BDNF Proteins) VGF (show VGF Proteins) through the PI3K/AKT (show AKT1 Proteins)/CREB (show CREB1 Proteins) pathway.
Disc1 truncation in Disc1tr Hemi mice induces a range of translationally relevant endophenotypes underpinned by glutamate (show GRIN1 Proteins) system dysfunction and altered brain connectivity.
DISC1 is a regulatory factor in ER calcium dynamics, linking a perturbed intracellular calcium signaling and schizophrenia pathogenesis.
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
disrupted in schizophrenia 1 protein
, disrupted in schizophrenia 1
, disrupted in schizophrenia 1 homolog