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Disrupted in Schizophrenia 1 Proteins (DISC1)

DISC1 encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. Additionally we are shipping DISC1 Antibodies (166) and DISC1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DISC1 27185 Q9NRI5
DISC1 244667 Q811T9
DISC1 307940 Q810H6
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Top DISC1 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$827.20
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$952.01
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$999.22
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DISC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Disrupted in Schizophrenia 1 (DISC1) Interaction Partners

Zebrafish Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. A Disc1 peptide binds to GSK3beta, and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin-mediated Wnt signaling and inhibiting GSK3beta activity.

  2. Disc1 and nrg1 (show NRG1 Proteins) function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 Proteins)-expressing precursor cells.

  3. Disc1 functions in the transcriptional repression of foxd3 (show FOXD3 Proteins) and sox10 (show SOX10 Proteins), thus mediating cranial neural crest cell migration and differentiation.

Human Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Proteins) activity via DISC1.

  2. Results suggest that DISC1 interacts with BA (show APP Proteins)CE1 and promotes lysosomal degradation of (show APP Proteins) BAC (show PSEN1 Proteins)E1, thus reducing the generation of Abeta

  3. It is anterogradely transported to the neurite tips, together with Lis1, and functions in neurite extension via suppression of GSK3beta activity.

  4. DISC1 disruption affects expression of neural cell fate markers and Wnt (show WNT2 Proteins) signaling.

  5. These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.

  6. DISC1 gene variations may affect the course of cognitive deficits found in patients suffering from the first episode of non-affective psychosis

  7. DISC1 acts as an important regulator of mitochondrial dynamics in both axons and dendrites.

  8. An association was found with DISC1 genetic variants and susceptibility to schizophrenia in a Han Chinese population.

  9. Results indicate that the neurexin (show NRXN1 Proteins) and neuroligin synaptic complex is intrinsically involved in the regulation of DISC1 function, thus contributing to a better understanding of the pathology of schizophrenia.

  10. Results with immature neurons from patients with schizophrenia and bipolar disorder showed common alterations in DISC1 levels and its cellular distribution, cAMP homeostasis, and cell migration

Mouse (Murine) Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function.

  2. Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Proteins) activity via Disc1.

  3. Results indicate that DISC1 attenuates Abeta (show APP Proteins) generation and cognitive deficits of APP (show APP Proteins)/PS1 (show PSEN1 Proteins) transgenic mice through promoting lysosomal degradation of BACE1 (show BACE Proteins)

  4. These results suggest that alteration of CB1R (show CNR1 Proteins)-mediated signaling in DN-DISC1 mice may underlie susceptibility to detrimental effects of adolescent cannabis exposure on adult behaviors.

  5. These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.

  6. These results suggest a mechanism by which cross-talk between DISC1 and NRG1 (show NRG1 Proteins)-ErbB4 (show ERBB4 Proteins) signalling may contribute to these deficits.

  7. Study found that DISC1 influences APP (show APP Proteins) C-terminal processing and Abeta (show APP Proteins) peptide generation, affects surface expression and internalization of APP (show APP Proteins) in neurons

  8. DISC1 regulates the expression of brain neurotrophin (show BDNF Proteins) VGF (show VGF Proteins) through the PI3K/AKT (show AKT1 Proteins)/CREB (show CREB1 Proteins) pathway.

  9. Disc1 truncation in Disc1tr Hemi mice induces a range of translationally relevant endophenotypes underpinned by glutamate (show GRIN1 Proteins) system dysfunction and altered brain connectivity.

  10. DISC1 is a regulatory factor in ER calcium dynamics, linking a perturbed intracellular calcium signaling and schizophrenia pathogenesis.

DISC1 Protein Profile

Protein Summary

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with DISC1

  • disrupted in schizophrenia 1 (disc1)
  • disrupted in schizophrenia 1 (DISC1)
  • disrupted in schizophrenia 1 (Disc1)
  • C1orf136 protein
  • DISC1 protein
  • SCZD9 protein

Protein level used designations for DISC1

disrupted in schizophrenia 1 protein , disrupted in schizophrenia 1 , disrupted in schizophrenia 1 homolog

GENE ID SPECIES
407621 Danio rerio
719086 Macaca mulatta
742093 Pan troglodytes
100060246 Equus caballus
488970 Canis lupus familiaris
613555 Bos taurus
100156849 Sus scrofa
100356059 Oryctolagus cuniculus
100580606 Nomascus leucogenys
27185 Homo sapiens
244667 Mus musculus
307940 Rattus norvegicus
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