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Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Additionally we are shipping DLX4 Antibodies (101) and DLX4 Kits (1) and many more products for this protein.
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Collectively, our findings indicate that DLX4 exerts opposing effects on the megakaryocytic and erythroid lineages in part by inducing IL-1beta (show IL1B Proteins) and NF-kappaB (show NFKB1 Proteins) signaling.
DLX4 induces CD44 (show CD44 Proteins) by stimulating IL-1beta (show IL1B Proteins)-mediated NF-kappaB (show NFKB1 Proteins) activity, thereby promoting peritoneal metastasis of ovarian cancer
This first finding of a DLX4 mutation in a family with Cleft lip and/or palate establishes DLX4 as a potential cause of human clefts
DLX4 promotes ovarian tumor angiogenesis in part by stimulating iNOS (show NOS2 Proteins) expression.
Aberrant DNA methylation (show HELLS Proteins) of the DLX4 and SIM1 (show SIM1 Proteins) genes may be a novel progression marker for uterine cervical low-grade squamous intraepithelial lesions.
indicate that gains of DLX4 and ERBB2 (show ERBB2 Proteins) occur in South African breast cancer patients irrespectively of their race and factors known to influence prognosis
a DLX4 overexpression vector lacking the 3'UTR was shown to abolish miR (show MLXIP Proteins)-122-induced inhibition of proliferation in the HCC (show FAM126A Proteins) cell line Hep3B.
DLX4 can functionally replace c-MYC (show MYC Proteins).
Methylated DLX4 is a potential biomarker that predicts poor prognosis after curative resection of pathologic stage I Non-Small Cell Lung Cancer.
DLX4 increased copy number was observed in 21.6% of the primary breast tumors and 24.3% of the sentinel lymph node metastasis
Genomic structure and functional control of the Dlx3 (show DLX3 Proteins)-7 bigene cluster
nuclear import of Dlx4 is compromised by specific residues that flank the nuclear localization signal
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.
distal-less homeobox 4
, beta protein 1
, distal-less homeo box 7
, distal-less homeo box 9
, homeobox protein DLX-4
, homeobox protein DLX-7
, homeobox protein DLX-8
, DII D