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DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3) ELISA Kits

DNAJC3 encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. Additionally we are shipping DnaJ (Hsp40) Homolog, Subfamily C, Member 3 Antibodies (37) and DnaJ (Hsp40) Homolog, Subfamily C, Member 3 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human DNAJC3 DNAJC3 5611 Q13217
Anti-Mouse DNAJC3 DNAJC3 100037258 Q91YW3
Anti-Rat DNAJC3 DNAJC3 63880 Q9R0T3
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More ELISA Kits for DnaJ (Hsp40) Homolog, Subfamily C, Member 3 Interaction Partners

Human DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3) interaction partners

  1. p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis

  2. Loss-of-function DNAJC3 mutations lead to a monogenic, recessive form of diabetes mellitus in humans.

  3. p58 (show CDK11B ELISA Kits)(IPK) suppresses coxsackievirus B3-induced apoptosis through selective activation of PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) pathway that requires activation of ATF6a (show ATF6 ELISA Kits) and subsequently upregulates mitofusin 2 (show MFN2 ELISA Kits).

  4. interplay between p38 (show CRK ELISA Kits) phosphorylation and p58 (show CDK11B ELISA Kits)(IPK) upregulation has key roles in modulating ERp29 (show ERP29 ELISA Kits)-induced cell-growth arrest and survival

  5. the crystal structure of human P58 (show CDK11B ELISA Kits)(IPK)

  6. Coxsackievirus B3 infection induces apoptosis through downregulation of p58IPK and activation of CHOP (show DDIT3 ELISA Kits) and SREBP1 (show SREBF1 ELISA Kits).

  7. Spleen cells from transgenic mice overexpressing (Hu)PKR (show PKLR ELISA Kits) were studied and compared to those from wild-type mice after drug treatment. Dact (show Actbeta ELISA Kits)-treated spleen cells were resistant to apoptosis; ConA-treated cells had decreased cell division.

  8. P58 (show CDK11B ELISA Kits)(IPK) is an important component of a negative feedback loop used by the cell to inhibit eIF2alpha (show EIF2A ELISA Kits) signaling, and thus attenuate the unfolded protein response.

  9. The study demonstrates that P58 (show CDK11B ELISA Kits)(IPK) inhibits endoplasmic reticulum (ER) stress and plays an important role in maintaining balance and stability of the ER in human retinal capillary endothelial cells.

Pig (Porcine) DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3) interaction partners

  1. Cloning, prokaryotic expression of novel swine gene P58IPK and its polyclonal antibody preparation

Mouse (Murine) DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3) interaction partners

  1. Chaperone protein p58 (show CDK11B ELISA Kits)(IPK) is expressed predominantly in retinal ganglion cells (RGC), inner retinal neurons, and the photoreceptor inner segments.

  2. p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis

  3. combined deletion of ATF6alpha (show ATF6 ELISA Kits) and the ER cochaperone p58 (show CDK11B ELISA Kits)(IPK) resulted in synthetic embryonic lethality.

  4. Data present a working model for P58 (show CDK11B ELISA Kits)(IPK) to act together with Bip (show HSPA5 ELISA Kits) to prevent protein aggregations and promote protein foldings within ER.

  5. Coxsackievirus B3 infection induces apoptosis through downregulation of p58IPK and activation of CHOP (show DDIT3 ELISA Kits) and SREBP1 (show SREBF1 ELISA Kits).

  6. mechanism by which P58 (show CDK11B ELISA Kits)(IPK) functions to promote protein folding within the endoplasmic reticulum, determined from the crystal structure of P58 (show CDK11B ELISA Kits)(IPK)

  7. renal injury inflicted by expression of the folding mutants was markedly enhanced by haploinsufficiency of the endoplasmic reticulum cochaperone p58 (show CDK11B ELISA Kits)(IPK).

  8. The stress of unfolded proteins in the ER activates P58(IPK) transcription through an ER stress-response element in its promoter. P58(IPK) interacts with & inhibits PERK, which protects cells during the ER-stress response by reducing protein synthesis.

  9. Insulin (show INS ELISA Kits) deficiency associated with the absence of P58 (show CDK11B ELISA Kits)(IPK) mimics beta-cell failure associated with type 1 and late-stage type 2 diabetes.

  10. absence of P58 (show CDK11B ELISA Kits)(IPK) led to an increase in eIF2alpha (show EIF2A ELISA Kits) phosphorylation and decreased influenza virus mRNA translation

DnaJ (Hsp40) Homolog, Subfamily C, Member 3 (DNAJC3) Antigen Profile

Antigen Summary

This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR).

Gene names and symbols associated with DNAJC3

  • DnaJ (Hsp40) homolog, subfamily C, member 3 (dnajc3) antibody
  • DnaJ (Hsp40) homolog, subfamily C, member 3 (DNAJC3) antibody
  • DNAJ heat shock N-terminal domain-containing protein (dnajc3) antibody
  • DnaJ (Hsp40) homolog, subfamily C, member 3 (Dnajc3) antibody
  • AA408985 antibody
  • AU067833 antibody
  • cg8286 antibody
  • DDBDRAFT_0186884 antibody
  • DDBDRAFT_0233602 antibody
  • DDB_0186884 antibody
  • DDB_0233602 antibody
  • dnajc3 antibody
  • Dnajc3a antibody
  • Dnajc3b antibody
  • ERdj6 antibody
  • HP58 antibody
  • mp58 antibody
  • p58 antibody
  • p58IPK antibody
  • Prkri antibody
  • wu:fb64f06 antibody
  • zgc:56356 antibody
  • zgc:77731 antibody

Protein level used designations for DNAJC3

dnaJ homolog subfamily C member 3 , DnaJ (Hsp40) homolog, subfamily C, member 3 , Interferon-induced, double-stranded RNA-activated protein kinase inhibitor , TPR repeat-containing protein , endoplasmic reticulum DnaJ protein 6 , interferon-induced, double-stranded RNA-activated protein kinase inhibitor , protein kinase inhibitor of 58 kDa , protein kinase inhibitor p58 , protein-kinase, interferon-inducible double stranded RNA dependent inhibitor , DnaJ (Hsp40) homolog, subfamily C, member 3A , DnaJ (Hsp40) homolog, subfamily C, member 3B , protein kinase, interferon inducible double stranded RNA dependent inhibitor

GENE ID SPECIES
322544 Danio rerio
476966 Canis lupus familiaris
496977 Xenopus (Silurana) tropicalis
695757 Macaca mulatta
736800 Pan troglodytes
8625524 Dictyostelium discoideum AX4
100019766 Monodelphis domestica
100059810 Equus caballus
100393937 Callithrix jacchus
100446513 Pongo abelii
100467911 Ailuropoda melanoleuca
100597711 Nomascus leucogenys
379791 Xenopus laevis
5611 Homo sapiens
286770 Bos taurus
100154166 Sus scrofa
100037258 Mus musculus
63880 Rattus norvegicus
418787 Gallus gallus
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