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DNAJB6 encodes a member of the DNAJ protein family. Additionally we are shipping DnaJ (Hsp40) Homolog, Subfamily B, Member 6 Antibodies (87) and DnaJ (Hsp40) Homolog, Subfamily B, Member 6 Proteins (19) and many more products for this protein.
the cytoprotective effects of DNAJB6(S) may be mediated, at least in part, by the mitochondrial pathway of apoptosis.
The results indicate both genetic and physical interactions between disease-linked RNA-binding proteinss and DNAJB6/mrj, suggesting etiologic overlap between the pathogenesis of adult-onset inherited myopathies initiated by mutations in hnRNPA2B1 (show HNRNPA2B1 ELISA Kits) and DNAJB6.
LGMD1D mutations in DNAJB6 disrupt its sarcoplasmic function suggesting a role for DNAJB6b in Z-disc organization and stress granule kinetics.
DNAJB6 mutations p.F91I and p.F91L show a significant reduction of the anti-aggregation function compared to the wild-type and p.F93L mutation
DnaJB6-protected yeast cells from polyglutamine toxicity and cured yeast of both [URE3] prions and weak variants of [PSI(+)] prions but not strong [PSI(+)] prions
This study showed that Complete loss of the DNAJB6 G/F domain and novel missense mutations cause distal-onset DNAJB6 myopathy.
DNAJB6a reduces AKT (show AKT1 ELISA Kits) signaling, and DNAJB6 expression in cancer cells reduces their proliferation and growth of xenograft esophageal squamous cell tumors in mice.
There was a positive correlation between DNAJB6 and IQGAP1 (show IQGAP1 ELISA Kits) expression.
Findings suggest a novel function of HSP70 (show HSP70 ELISA Kits)/MRJ/uPAR (show PLAUR ELISA Kits) complex in cell adhesion, invasion and migration, and may provide more understanding in the mechanisms of uPAR (show PLAUR ELISA Kits)-mediated cancer metastasis.
DNAJB6 G/F domain mutants disrupt the processing of nuclear TDP-43 (show TARDBP ELISA Kits) stress granules in mammalian cells.
Mrj(-/-) chorions at embryonic day 8.5 have expanded Rhox4b expression domains and do not form normal layers of gene expression suggesting that chorion patterning requires Mrj.
Data show that Mrj(-/-) embryos exhibit neural tube defects independent of the placenta phenotype, including exencephaly and thin-walled neural tubes, and suggest that Mrj plays an important role in neural stem cell self-renewal.
NFATc3 (show NFATC3 ELISA Kits) is negatively regulated by class II histone deacetylases through the DnaJ (show DNAJA2 ELISA Kits) (heat shock protein-40 (show DNAJB1 ELISA Kits)) superfamily member Mrj
Study demonstrates here that, in the developing placenta of the mouse, the absence of the Mrj co-chaperone prevents proteasome degradation of keratin 18 intermediate filaments, resulting in the formation of keratin inclusion bodies.
DnaJB6 is necessary for translocation of Slfn1 into the nucleus, where Slfn1 down-regulates cyclin D1 (show CCND1 ELISA Kits), induces cell-cycle arrest and programmes a quiescent state of T-cells
This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants\; however, not all variants have been fully described.
dnaJ homolog subfamily B member 6-B
, DnaJ-like 2 protein
, dnaJ homolog subfamily B member 6
, heat shock protein J2
, mammalian relative of DnaJ
, hsp40 homolog