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DOK proteins are enzymatically inert adaptor or scaffolding proteins. Additionally we are shipping DOK4 Proteins (6) and many more products for this protein.
Showing 10 out of 65 products:
Human Polyclonal DOK4 Primary Antibody for IHC (p), WB - ABIN392073
Favre, Gérard, Clauzier, Pontarotti, Olive, Nunès: DOK4 and DOK5: new Dok-related genes expressed in human T cells. in Genes and immunity 2003
Show all 2 references for ABIN392073
Human Polyclonal DOK4 Primary Antibody for EIA, IHC (p) - ABIN359961
Gérard, Ghiotto, Fos, Guittard, Compagno, Galy, Lemay, Olive, Nunès: Dok-4 is a novel negative regulator of T cell activation. in Journal of immunology (Baltimore, Md. : 1950) 2009
Human Polyclonal DOK4 Primary Antibody for ELISA, WB - ABIN1534026
Loftus, Kim, Sneddon, Kalush, Brandon, Fuhrmann, Mason, Crosby, Barnstead, Cronin, Deslattes Mays, Cao, Xu, Kang, Mitchell, Eichler, Harris, Venter, Adams: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. in Genomics 1999
the current study have explored in more detail the structure and function of the Dok-4 PTB (show PTBP1 Antibodies) domain.
DOK4 expression in human T cells has been demonstrated, and its genomic structure has been predicted.
IRS5/DOK4 and IRS6/DOK5 (show DOK5 Antibodies) represent two new signaling proteins with potential roles in insulin (show INS Antibodies) and IGF-1 (show IGF1 Antibodies) action
Results suggest that Dok-4, through activation of the Rap1 (show RABGEF1 Antibodies)-ERK1/2 (show MAPK1/3 Antibodies) pathway, regulates GDNF (show GDNF Antibodies)-mediated neurite outgrowth during neuronal development.
IRS-5 (DOK4) is significantly upregulated in 90% of examined clear cell RCCs. Studies on this gene has shown that it is regulated through chromatin remodeling in kidney cells
Epigenetic regulation of DOK4 expression is associated with non-small-cell lung cancer.
Dok-4 represents a novel negative regulator of T cells
Dok-4 can target Elk-4 (show ELK4 Antibodies) activity through multiple mechanisms, including binding of the transactivation domain, nuclear exclusion and protein destabilization.
Dok-4 is a constitutively membrane-localized adapter molecule that may function as an inhibitor of tyrosine kinase (show TYRO3 Antibodies) signaling in epithelial cells.
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.
, downstream of tyrosine kinase 4
, insulin receptor substrate 5
, docking protein 4