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DOK6 is a member of the DOK (see DOK1\; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Docking Protein 6 Antibodies (40) and Docking Protein 6 Kits (4) and many more products for this protein.
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DOK-6 is involved in RET (show RET Proteins) signaling with less influence when compared with DOK-1 (show DOK1 Proteins), DOK-4 (show DOK4 Proteins), and SHC (show SHC1 Proteins).
Dok-6 binds to the phosphorylated Ret (show RET Proteins) Tyr (show TYR Proteins)(1062) residue resulting in phosphorylation of tyrosine residue(s) located within the unique C terminus of Dok-6 predominantly through a Src (show SRC Proteins)-dependent mechanism
Dok6 selectively binds to the NPQY motif of TrkC (show NTRK3 Proteins) through its phosphotyrosine-binding (PTB (show PTBP1 Proteins)) domain in a kinase activity-dependent manner.
DOK6 is a member of the DOK (see DOK1\; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004
downstream of tyrosine kinase 6
, downstream of tyrosine kinases 6
, docking protein 6