Dopachrome Tautomerase Proteins (DCT)

Involved in regulating eumelanin and phaeomelanin levels. Additionally we are shipping DCT Antibodies (101) and DCT Kits (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DCT 1638 P40126
DCT 13190 P29812
Rat DCT DCT 290484  
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Top DCT Proteins at

Showing 5 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 13 to 16 Days

DCT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

More Proteins for Dopachrome Tautomerase (DCT) Interaction Partners

Human Dopachrome Tautomerase (DCT) interaction partners

  1. High DCT expression is associated with HPV16 Infection.

  2. Data indicate that the caveolin-1 (CAV1 (show CAV1 Proteins)) control on dopachrome tautomerase (DCT) gene expression, DCT post-translational processing, and subcellular distribution is cell phenotype-dependent.

  3. The effect of DCT on UVR DNA damage responses and survival pathways in melanocytes was examined by knockdown experiments using melanoma cells, neonatal melanoblasts in monoculture and in co-culture with keratinocytes.

  4. Report dopachrome tautomerase expression in mealanocytic tumors.

  5. The results suggested that the miRNAs may be involved in MITF (show MITF Proteins) regulation of TYR (show TYR Proteins), TYRP1 (show TYRP1 Proteins) and TYRP2, which provides a new clue for understanding the role of miRNAs in melanocyte dysfunctional disease.

  6. Data suggest that macrophage migration inhibitory factor (MIF (show MIF Proteins)) and d-dopachrome tautomerase (show DDT Proteins) (d-DT) act cooperatively to inhibit steady-state phosphorylation and activation of AMPK (show PRKAA1 Proteins) in LKB1 (show STK11 Proteins) wild type and LKB1 (show STK11 Proteins) mutant non-small cell lung carcinomas cells.

  7. human TRP2 counteracts apoptotic cell death induction, possibly by means of its L-dopachrome tautomerase activity, and negatively affects the p53 (show TP53 Proteins) pathway

  8. Trp2 SNP2 allele is a risk factor for the development and severity of degenerative disc disease in a Chinese Han population.

  9. Data suggest that OTX2 (show OTX2 Proteins) may regulate retinal pigment epithelium (RPE (show RPE Proteins))-specific target genes, such as DOPAchrome tautomerase (DCT), thereby maintaining the homeostasis of RPE (show RPE Proteins).

  10. Because TRP-2(181-190) overlaps with the known HLA-A*0201-presented epitope TRP-2(180-188), an 11mer peptide encompassing both epitopes might be of specific value for vaccination of a broad population of melanoma patients.

Mouse (Murine) Dopachrome Tautomerase (DCT) interaction partners

  1. MIF-2 (show HSPA5 Proteins)/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI (show SLPI Proteins)- and ATF4 (show ATF4 Proteins)-dependent mechanisms.

  2. the slaty mutant melanocytes seem to be more sensitive to ultraviolet rays and oxidative stress than black melanocytes.

  3. A novel murine model of vitiligo (show MITF Proteins) is established by sequential prime/boost immunizations into the hind footpad and tail dermis with tyrosinase-related protein 2 (TRP2)-180 (SVYDFFVWL) peptide.

  4. study indicates that tumor antigen (TRP2) expressed in MCMV induces a strong and long-lasting anti-melanoma effect through an antibody-dependent mechanism

  5. Vaccine formulations with synthetic long peptides for treating B16F10 skin melanoma fails to elicit strong CD8 (show CD8A Proteins) T cell responses to self-differentiation antigens TRP-2 and gp100 (show PMEL Proteins).

  6. level of gene targeting was not improved by the DSB induction, indicating a limited capacity of I-SceI to mediate homologous recombination at the Dct locus

  7. Recombinant dopachrome tautomerase was expressed and purified, without its carboxy-terminal transmembrane region. Analysis of dopachrome tautomerase tryptic peptides by MALDI-TOF/TOF (show FEZF2 Proteins) determined N-glycosylation as a primary post-translational modification.

  8. Dopachrome tautomerase inactivation elevates the level of ROS (show ROS1 Proteins), increases the numbers of sunburn cells and apoptotic cells, and decreases the amount of eumelanin in the epidermis upon exposure to chronic UVA radiation

  9. the TRP-2 polypeptide folds in the endoplasmic reticulum (ER) in the presence of calnexin (show CANX Proteins), until it reaches a dithiothreitol-resistant conformation enabling its ER exit to the Golgi

  10. Results describe the generation of a knockout of the dopachrome tautomerase gene in mice with effects restricted to pigment production and coat color.

DCT Protein Profile

Protein Summary

Involved in regulating eumelanin and phaeomelanin levels.

Gene names and symbols associated with Dopachrome Tautomerase Proteins (DCT)

  • dopachrome tautomerase (dct)
  • dopachrome tautomerase (DCT)
  • dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) (dct)
  • dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) (DCT)
  • dopachrome tautomerase (Dct)
  • dopachrome tautomerase-like (LOC100353923)
  • transfer RNA proline 2 (anticodon AGG) (TRNAP2)
  • transient receptor potential cation channel, subfamily C, member 2, pseudogene (Trpc2)
  • DT protein
  • RGD1564975 protein
  • slaty protein
  • slt protein
  • TRNP1 protein
  • TRP-2 protein
  • TRP2 protein
  • Trrp2 protein
  • Tyrp-2 protein
  • Tyrp2 protein

Protein level used designations for Dopachrome Tautomerase Proteins (DCT)

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) , L-dopachrome tautomerase-like , DT , L-dopachrome Delta-isomerase , L-dopachrome tautomerase , TRP2 , dopachrome delta-isomerase , tyrosinase-related protein 2 , tyrosine-related protein 2 , SLATY locus protein , tyrosinase-related protein-2 , TRP-2 , dopachrome delta isomerase , tyrosinase related protein 2 , rTrp2 , short transient receptor potential channel 2 , transient receptor protein 2

549915 Xenopus (Silurana) tropicalis
694577 Macaca mulatta
100058776 Equus caballus
100230498 Taeniopygia guttata
100381161 Xenopus laevis
100389709 Callithrix jacchus
100438537 Pongo abelii
100595345 Nomascus leucogenys
1638 Homo sapiens
13190 Mus musculus
290484 Rattus norvegicus
574066 Sus scrofa
100718804 Cavia porcellus
280761 Bos taurus
485520 Canis lupus familiaris
100170232 Ovis aries
395775 Gallus gallus
100353923 Oryctolagus cuniculus
7218 Homo sapiens
64573 Rattus norvegicus
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