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Involved in regulating eumelanin and phaeomelanin levels. Additionally we are shipping DCT Antibodies (101) and DCT Kits (32) and many more products for this protein.
Showing 5 out of 8 products:
High DCT expression is associated with HPV16 Infection.
Data indicate that the caveolin-1 (CAV1 (show CAV1 Proteins)) control on dopachrome tautomerase (DCT) gene expression, DCT post-translational processing, and subcellular distribution is cell phenotype-dependent.
The effect of DCT on UVR DNA damage responses and survival pathways in melanocytes was examined by knockdown experiments using melanoma cells, neonatal melanoblasts in monoculture and in co-culture with keratinocytes.
Report dopachrome tautomerase expression in mealanocytic tumors.
The results suggested that the miRNAs may be involved in MITF (show MITF Proteins) regulation of TYR (show TYR Proteins), TYRP1 (show TYRP1 Proteins) and TYRP2, which provides a new clue for understanding the role of miRNAs in melanocyte dysfunctional disease.
Data suggest that macrophage migration inhibitory factor (MIF (show MIF Proteins)) and d-dopachrome tautomerase (show DDT Proteins) (d-DT) act cooperatively to inhibit steady-state phosphorylation and activation of AMPK (show PRKAA1 Proteins) in LKB1 (show STK11 Proteins) wild type and LKB1 (show STK11 Proteins) mutant non-small cell lung carcinomas cells.
human TRP2 counteracts apoptotic cell death induction, possibly by means of its L-dopachrome tautomerase activity, and negatively affects the p53 (show TP53 Proteins) pathway
Trp2 SNP2 allele is a risk factor for the development and severity of degenerative disc disease in a Chinese Han population.
Data suggest that OTX2 (show OTX2 Proteins) may regulate retinal pigment epithelium (RPE (show RPE Proteins))-specific target genes, such as DOPAchrome tautomerase (DCT), thereby maintaining the homeostasis of RPE (show RPE Proteins).
Because TRP-2(181-190) overlaps with the known HLA-A*0201-presented epitope TRP-2(180-188), an 11mer peptide encompassing both epitopes might be of specific value for vaccination of a broad population of melanoma patients.
MIF-2 (show HSPA5 Proteins)/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI (show SLPI Proteins)- and ATF4 (show ATF4 Proteins)-dependent mechanisms.
the slaty mutant melanocytes seem to be more sensitive to ultraviolet rays and oxidative stress than black melanocytes.
A novel murine model of vitiligo (show MITF Proteins) is established by sequential prime/boost immunizations into the hind footpad and tail dermis with tyrosinase-related protein 2 (TRP2)-180 (SVYDFFVWL) peptide.
study indicates that tumor antigen (TRP2) expressed in MCMV induces a strong and long-lasting anti-melanoma effect through an antibody-dependent mechanism
Vaccine formulations with synthetic long peptides for treating B16F10 skin melanoma fails to elicit strong CD8 (show CD8A Proteins) T cell responses to self-differentiation antigens TRP-2 and gp100 (show PMEL Proteins).
level of gene targeting was not improved by the DSB induction, indicating a limited capacity of I-SceI to mediate homologous recombination at the Dct locus
Recombinant dopachrome tautomerase was expressed and purified, without its carboxy-terminal transmembrane region. Analysis of dopachrome tautomerase tryptic peptides by MALDI-TOF/TOF (show FEZF2 Proteins) determined N-glycosylation as a primary post-translational modification.
Dopachrome tautomerase inactivation elevates the level of ROS (show ROS1 Proteins), increases the numbers of sunburn cells and apoptotic cells, and decreases the amount of eumelanin in the epidermis upon exposure to chronic UVA radiation
the TRP-2 polypeptide folds in the endoplasmic reticulum (ER) in the presence of calnexin (show CANX Proteins), until it reaches a dithiothreitol-resistant conformation enabling its ER exit to the Golgi
Results describe the generation of a knockout of the dopachrome tautomerase gene in mice with effects restricted to pigment production and coat color.
Involved in regulating eumelanin and phaeomelanin levels.
dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)
, L-dopachrome tautomerase-like
, L-dopachrome Delta-isomerase
, L-dopachrome tautomerase
, dopachrome delta-isomerase
, tyrosinase-related protein 2
, tyrosine-related protein 2
, SLATY locus protein
, tyrosinase-related protein-2
, dopachrome delta isomerase
, tyrosinase related protein 2
, short transient receptor potential channel 2
, transient receptor protein 2