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Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Additionally we are shipping DRAXIN Antibodies (51) and DRAXIN Kits (1) and many more products for this protein.
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results suggest that draxin functions as a repulsive guidance cue for PCN migration. However, we observed no significant differences in PCN distribution between draxin(-/-) and wild type embryos.
Neucrin is a unique secreted Wnt (show WNT2 Proteins) antagonist that is predominantly expressed in developing neural tissues.
draxin may regulate mouse trunk neural crest cell migration.
These results suggest that draxin from neocortical neurons controls thalamocortical projections into the neocortex, and that this effect is mediated through the DCC (show DCC Proteins) and Neo1 (show NEO1 Proteins) receptors.
Study elucidates for the first time, molecular events in draxin repulsion and links draxin and DCC to MAP1B to axon guidance cue signaling.
The combinatorial guidance activities of draxin and Tsukushi (show TSKU Proteins) are essential for forebrain commissure formation
Draxin interacts with subnanomolar affinity to the netrin receptor DCC (show DCC Proteins), in a region of DCC (show DCC Proteins) distinct from its netrin-binding domain.
These results suggest that draxin functions as an inhibitory guidance cue for olfactory bulb axons and indicate its contribution to the formation of the lateral olfactory tract.
This study found that draxin, a repulsive axon guidance cue, was widely expressed in the developing hippocampus and draxin deficient mice possessed a smaller hippocampus.
draxin knockout mice showed defasciculation of spinal cord commissural axons & absence of all forebrain commissures; draxin is a previously unknown chemorepulsive axon guidance molecule (show NTNG1 Proteins) required for the development of spinal cord & forebrain commissures
Draxin-derived 22-aa fragment is sufficient for binding to Ntn1a.
Neucrin is a unique secreted Wnt (show WNT2 Proteins) antagonist that is predominantly expressed in developing neural tissues and plays roles in neural development in zebrafish.
Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord and cortical explants in vitro. Binds directly to the neurites and growth cones.
dorsal inhibitory axon guidance protein
, dorsal repulsive axon guidance protein
, neural tissue-specific cysteine-rich protein