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anti-Double C2-Like Domains, beta (DOC2B) Antibodies

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. Additionally we are shipping DOC2B Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DOC2B 81820 P70610
DOC2B 8447  
DOC2B 13447 P70169
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Top anti-DOC2B Antibodies at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated WB Western Blot analysis of DOC2B expression in transfected 293T cell line by DOC2B MaxPab polyclonal antibody.Lane 1: DOC2B transfected lysate(45.32 KDa).Lane 2: Non-transfected lysate. DOC2B MaxPab polyclonal antibody. Western Blot analysis of DOC2B expression in human kidney. 50 μg Log in to see 9 Days
$430.00
Details
Mouse Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Mouse Rabbit Un-conjugated IHC   500 μg Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated IF, ELISA, WB   50 μL Log in to see 9 to 11 Days
$313.50
Details
Rat Rabbit Un-conjugated   500 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit FITC ELISA, WB   100 μg Log in to see 1 to 2 Days
$572.00
Details
Human Mouse Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$742.50
Details
Mouse Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
$454.67
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p)   0.1 mL Log in to see 8 to 11 Days
$439.69
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 1 to 2 Days
$485.57
Details

DOC2B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus) , ,



Human , ,
,


Mouse (Murine) , ,



Top referenced anti-DOC2B Antibodies

  1. Mouse (Murine) Polyclonal DOC2B Primary Antibody for IHC, WB - ABIN350292 : Kojima, Fukuda, Aruga, Mikoshiba: Calcium-dependent phospholipid binding to the C2A domain of a ubiquitous form of double C2 protein (Doc2 beta). in Journal of biochemistry 1997 (PubMed)
    Show all 2 references for ABIN350292

  2. Mouse (Murine) Polyclonal DOC2B Primary Antibody for IHC - ABIN350293 : Nagano, Orita, Sasaki, Naito, Sakaguchi, Maeda, Watanabe, Kominami, Uchiyama, Takai: Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport. in The Journal of biological chemistry 1998 (PubMed)
    Show all 2 references for ABIN350293

  3. Human Polyclonal DOC2B Primary Antibody for WB - ABIN521906 : Yao, Gaffaney, Kwon, Chapman: Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. in Cell 2011 (PubMed)

More Antibodies against DOC2B Interaction Partners

Human Double C2-Like Domains, beta (DOC2B) interaction partners

  1. promoter hypermethylation and silencing of the DOC2B gene is an early and frequent event during cervical carcinogenesis and whose reduced expression due to DNA promoter methylation may lead to selective cervical tumor growth

  2. Study analyzed Doc2alpha and Doc2beta and found that Doc2 (show DAB2 Antibodies) responds to changes in [Ca2 (show CA2 Antibodies)+], with markedly slower kinetics as compared to the cytosolic domain of syt I (syt (show SYT1 Antibodies)), and operates on a timescale consistent with asynchronous neurotransmitter release.

Mouse (Murine) Double C2-Like Domains, beta (DOC2B) interaction partners

  1. study identifies a critical role for DOC2B in insulin (show INS Antibodies)-stimulated glucose uptake in adipocytes, and for the synergistic regulation of GSIS by DOC2A (show DOC2A Antibodies) and DOC2B in beta cells.

  2. Data demonstrate that Munc13-1 (show UNC13A Antibodies) and DOC2B have different effects on network activity and that by enhancing asynchronous release, DOC2B exerts its properties to increase spiking activity and elevate synchronization between neurons within network bursts

  3. Hence these data support a working model wherein Doc2b functions as a docking platform/scaffold for transient interactions with the multiple Munc18 isoforms operative in insulin (show INS Antibodies) release, promoting SNARE (show VTI1B Antibodies) assembly.

  4. Doc2b is a limiting factor in SNARE (show VTI1B Antibodies) exocytosis events pertinent to glycaemic regulation in vivo. Doc2b enrichment may provide a novel means to simultaneously boost islet and skeletal muscle function in vivo in the treatment and/or prevention of diabetes.

  5. Mutations that disrupt Ca(2 (show CA2 Antibodies))-binding activity endow Doc2beta with novel functional properties during synaptic transmission.

  6. Doc2b acts to inhibit vesicle priming during prolonged calcium elevations, thus protecting unprimed vesicles from fusing prematurely, and redirecting them to refill the readily releasable pool after relaxation of the calcium signal.

  7. Doc2b is a key positive regulator of Munc18c (show STXBP3 Antibodies)-syntaxin 4 (show STX4 Antibodies)-mediated insulin (show INS Antibodies) secretion as well as of insulin (show INS Antibodies) responsiveness in skeletal muscle, and thus a key effector for glucose homeostasis in vivo.

  8. The data of this study suggested that Doc2s are modulators of spontaneous synaptic transmission that act by a Ca(2 (show CA2 Antibodies)+)-independent mechanism.

  9. study found that Doc2b is a high-affinity Ca2 (show CA2 Antibodies)+ sensor for half (hippocampus) or most (cerebellum) of the spontaneous neurotransmitter release events in CNS synapses

  10. tyrosine phosphorylation of Munc18c (show STXBP3 Antibodies) induces a switch in binding specificity from syntaxin 4 (show STX4 Antibodies) to Doc2beta

DOC2B Antigen Profile

Protein Summary

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes\; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells.

Gene names and symbols associated with DOC2B

  • double C2-like domains, beta-like (LOC100369196) antibody
  • double C2-like domains, beta (DOC2B) antibody
  • double C2-like domains, beta (doc2b) antibody
  • double C2-like domains, beta (LOC100343594) antibody
  • double C2-like domains, beta (Doc2b) antibody
  • double C2, beta (Doc2b) antibody
  • DOC2BL antibody

Protein level used designations for DOC2B

double C2-like domains, beta-like , double C2-like domains, beta , double C2-like domain-containing protein beta-like , doc2-beta , double C2, beta , double C2-like domain-containing protein beta , double C2 protein beta

GENE ID SPECIES
100369196 Saccoglossus kowalevskii
417624 Gallus gallus
454397 Pan troglodytes
611233 Canis lupus familiaris
699082 Macaca mulatta
785428 Bos taurus
100006713 Danio rerio
100343594 Oryctolagus cuniculus
81820 Rattus norvegicus
8447 Homo sapiens
13447 Mus musculus
Selected quality suppliers for anti-DOC2B (DOC2B) Antibodies
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