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DUX4 is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. Additionally we are shipping and many more products for this protein.
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Human Monoclonal DUX4 Primary Antibody for ICC, IF - ABIN863109
Kowaljow, Marcowycz, Ansseau, Conde, Sauvage, Mattéotti, Arias, Corona, Nuñez, Leo, Wattiez, Figlewicz, Laoudj-Chenivesse, Belayew, Coppée, Rosa: The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein. in Neuromuscular disorders : NMD 2007
Show all 3 references for ABIN863109
these data support a model in which DME1 and DME2 myogenic enhancers associate with the DUX4 promoter in skeletal myocytes and activate transcription when epigenetically derepressed in FSHD, resulting in the pathological misexpression of DUX4-fl.
proposed that Wnt/beta-catenin signaling is important for transcriptional repression of DUX4
Impact of Dux4 on p53 (show TP53 Antibodies)/p21 (show CDKN1A Antibodies) signal pathway, which controls the checkpoint in cell cycle progression. Overexpression of Dux4 increased p21 (show CDKN1A Antibodies) mRNA and protein level, while expression of p53 (show TP53 Antibodies), phospho-p53 (show TP53 Antibodies) remained unchanged.
DUX4 possesses redundant mechanisms to assure nuclear entrance and that its various transcription-factor associated domains play an essential role in cell toxicity.
Our findings demonstrate a role for DUX4 and repetitive elements in mammalian germline evolution and in FSHD muscular dystrophy.
DUX4-expressing embryonic stem cells downregulate pluripotency markers and rapidly differentiate
results suggest that DUX4 regulates overlapped and distinct groups of genes and pathways in human and mouse cells as evident by the selective up-regulation of genes involved in myogenesis and gametogenesis in human RD and immortalized cells
CIC-DUX4 sarcoma represents a novel translocation-associated sarcoma with distinctive histopathologic features and rapid disease progression.
DUX4 gene is activated in a small number of myonuclei, the DUX4 proteins diffuse to adjacent nuclei where they activate target genes such as PITX1 (show PITX1 Antibodies).
DUX4, the primary candidate for facioscapulohumeral muscular dystrophy (FSHD) pathogenesis, is upregulated over ten-fold in FSHD myoblasts and myotubes with short telomeres, and its expression is inversely proportional to telomere length.
This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that contains two homeoboxes; the repeat-array and ORF is conserved in other mammals. There was no evidence for transcription from standard cDNA libraries however RTPCR and in-vitro expression experiments indicate that the ORF is transcribed and the encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD).
double homeobox, 4
, double homeobox protein 10
, double homeobox protein 4
, double homeobox protein 4/10