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DCX encodes a member of the doublecortin family. Additionally we are shipping Doublecortin Kits (41) and Doublecortin Proteins (12) and many more products for this protein.
Showing 10 out of 165 products:
Mouse (Murine) Monoclonal Doublecortin Primary Antibody for IF, WB - ABIN968637
des Portes, Pinard, Billuart, Vinet, Koulakoff, Carrié, Gelot, Dupuis, Motte, Berwald-Netter, Catala, Kahn, Beldjord, Chelly: A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome. in Cell 1998
Show all 3 Pubmed References
Human Monoclonal Doublecortin Primary Antibody for ICC, FACS - ABIN969513
Evangelisti, Florian, Massimi, Dominici, Giannini, Galardi, Buè, Massalini, McDowell, Messi, Gulino, Farace, Ciafrè: MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
Mouse (Murine) Polyclonal Doublecortin Primary Antibody for ELISA, WB - ABIN4305985
Klempin, Kronenberg, Cheung, Kettenmann, Kempermann: Properties of doublecortin-(DCX)-expressing cells in the piriform cortex compared to the neurogenic dentate gyrus of adult mice. in PLoS ONE 2011
Human Monoclonal Doublecortin Primary Antibody for IF, ELISA - ABIN560579
Jiang, Brackeva, Stangé, Verhaeghen, Costa, Couillard-Després, Rotheneichner, Aigner, Van Schravendijk, Pipeleers, Ling, Gorus, Martens: LC-MS/MS identification of doublecortin as abundant beta cell-selective protein discharged by damaged beta cells in vitro. in Journal of proteomics 2013
this suggests that the microtubule-interacting doublecortin domain observed in cryo-electron micrographs is the C-terminal domain rather than the N-terminal one.
From this family, we conclude that a DCX mutation causes a pleiotropic phenotype in the female even if X chromosome inactivation pattern is not skewed, and the novel missense mutation in DCX produced relatively mild dysfunction of the doublecortin protein.
We identified a novel DCX mutation c.785A > G, p.Asp262Gly in a family with X-linked lissencephaly and subcortical band heterotopia
In high-risk metastatic Neuroblastoma (show ARHGEF16 Antibodies), TH and DCX mRNA quantification could be used for the assessment of response to treatment and for early detection of progressive disease or relapses.
Results point to a critical role of doublecortin in the formation of the neuromuscular junctions.
DCX-positive cells occur in a wide range of hypothalamic nuclei in humans, mice and sheep.
human DCX protein was expressed in human adipose stem cells, collagen II was decreased while aggrecan (show ACAN Antibodies), matrilin 2 (show MATN2 Antibodies), and GDF5 (show GDF5 Antibodies) were increased during the 14-day pellet culture.
We propose that DCDC2 (show DCDC2 Antibodies) is a tumor suppressor gene of HCC (show FAM126A Antibodies).
in utero doublecortin knockdown, but not knockout, shows a neocortical neuronal migration phenotype.
Immunoblots revealed that depressed subjects displayed increased expression of doublecortin.
MEIS2 (show MEIS2 Antibodies) associates with chromatin-bound PBX1 (show PBX1 Antibodies), recruits PARP1/ARTD1 (show PARP1 Antibodies), and initiates PARP1 (show PARP1 Antibodies)-mediated eviction of H1 from the chromatin fiber.
The regulation axis from microRNA-128-3p to doublecortin is critical for hippocampus-related contextual learning not only in wild type, but also in mice infused with Abeta (show APP Antibodies)-42.
Findings demonstrate the direct requirement of ADAM10 (show ADAM10 Antibodies) in cortical radial migration and reveal the underlying mechanism by linking ADAM10 (show ADAM10 Antibodies)-initiated regulated intramembrane proteolysis of Notch (show NOTCH1 Antibodies) to the regulation of microtubule cytoskeleton through transcriptional control of Dcx expression
Dcx is a new marker for the Pax7 (show PAX7 Antibodies)(+)MyoD (show MYOD1 Antibodies)(-) subpopulation, which contributes to myofiber maturation during muscle regeneration.
DCX-positive cells resembling immature and developing neurons were found in mice and sheep and human hypothalamus.
we showed that miR (show MLXIP Antibodies)-29a directly regulated its target protein Doublecortin (DCX) expression, which further modulated axon branching in primary culture.
Cdk5 (show CDK5 Antibodies) and its substrates, Dcx and p27kip1 (show CDKN1B Antibodies), regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons.
Doublecortin knockout mice show lamination defects of the hippocampal pyramidal cell layer largely restricted to the CA3 (show CA3 Antibodies) region.
Dcx protein- and mRNA-levels reflected changes in neurogenesis
DCX is dispensable for the development of new neurons in adult mice
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
doublecortex; lissencephaly, X-linked (doublecortin)
, neuronal migration protein doublecortin
, lissencephaly, X-linked (doublecortin)