Doublecortin Domain Containing 2 Proteins (DCDC2)

DCDC2 encodes a doublecortin domain-containing family member. Additionally we are shipping DCDC2 Antibodies (96) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DCDC2 51473 Q9UHG0
DCDC2 291130 D3ZR10
DCDC2 195208 Q5DU00
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Top DCDC2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,340.33
Details

DCDC2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus)

Mouse (Murine)

More Proteins for Doublecortin Domain Containing 2 (DCDC2) Interaction Partners

Human Doublecortin Domain Containing 2 (DCDC2) interaction partners

  1. Study identified biallelic missense mutations or in-frame deletion in DCDC2 in children affected with neonatal sclerosi. Mutations involve highly conserved amino acids in the doublecortin (show DCX Proteins) domains of the protein. In cholangiocytes, DCDC2 protein is normally located in the cytoplasm and cilia, whereas in patients the mutated protein is accumulated in the cytoplasm, absent from cilia, and associated with ciliogenesis defect.

  2. Developmental dyslexia genetic (DCDC2) and environmental factors (smoke and miscarriage) underlie ADHD traits supporting a potential pleiotropic effect.

  3. that endogenous DYX1C1 (show DYX1C1 Proteins) localizes to the base of the cilium, whereas DCDC2 localizes along the entire axoneme of the cilium

  4. DCDC2 Polymorphism is associated with reading disability.

  5. off-target, non-immune mediated effects of the mTOR (show FRAP1 Proteins)-inhibitor everolimus on the podocyte cytoskeleton might involve regulation of microtubules, revealing a potential novel role of TUBB2B (show TUBB2B Proteins) and DCDC2 in glomerular podocyte development

  6. This study demonstrated that DCDC2 intron 2 deletion impair illusory visual motion perception-specifically processed by the magnocellular-dorsal (M-D) stream-is impaired in children with Developmental dyslexia.

  7. A nonsynonymous polymorphism in DCDC2 (corrected P = 0.002) and a noncoding variant in S100B (show S100B Proteins) (corrected P = 0.016) showed a significant association with spelling performance in families of German origin.

  8. Our results reveal DCDC2a to be a deafness gene and a player in hair cell kinocilia and supporting cell (show PTPRJ Proteins) primary cilia length regulation likely via its role in microtubule formation and stabilization.

  9. the association of DCDC2 and KIAA0319 (show KIAA0319 Proteins) with Developmental dyslexia in Chinese population should be further validated

  10. In a population carrying a deletion in the DCDC2 gene, impaired motion perception was identified in subjects with dyslexia.

Mouse (Murine) Doublecortin Domain Containing 2 (DCDC2) interaction partners

  1. Behavioral results revealed deficits in rapid auditory processing, working memory and reference memory in Dcdc2(del2/del2) mice when compared with matched wild types.

  2. Results link the function of the dyslexia-associated gene Dcdc2 to spike timing through activity of N-methyl-D-aspartate receptor (show GRIN1 Proteins) (NMDAR (show GRIN1 Proteins))

  3. These results indicate that Dcdc2 is not required for neurogenesis, neuronal migration or differentiation in mice, but may have partial functional redundancy with doublecortin (show DCX Proteins).

  4. heterozygous and homozygous mutations of Dcdc2 result in persistent visuo-spatial memory deficits, as well as visual discrimination and long-term memory deficits

DCDC2 Protein Profile

Protein Summary

This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with DCDC2

  • doublecortin domain containing 2 (DCDC2)
  • doublecortin domain containing 2B (dcdc2b)
  • doublecortin domain containing 2 (Dcdc2)
  • doublecortin domain containing 2a (Dcdc2a)
  • AW492955 protein
  • Dcdc2 protein
  • DCDC2A protein
  • RU2 protein
  • RU2S protein
  • zgc:123267 protein

Protein level used designations for DCDC2

doublecortin domain containing 2 , doublecortin domain-containing protein 2 , doublecortin domain-containing protein 2-like

GENE ID SPECIES
100052480 Equus caballus
472225 Pan troglodytes
563259 Danio rerio
707472 Macaca mulatta
100352162 Oryctolagus cuniculus
100412921 Callithrix jacchus
100017769 Monodelphis domestica
51473 Homo sapiens
291130 Rattus norvegicus
488244 Canis lupus familiaris
100297854 Bos taurus
195208 Mus musculus
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