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DCDC2 encodes a doublecortin domain-containing family member. Additionally we are shipping DCDC2 Antibodies (98) and many more products for this protein.
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DCDC2 Polymorphism is associated with reading disability.
off-target, non-immune mediated effects of the mTOR (show FRAP1 Proteins)-inhibitor everolimus on the podocyte cytoskeleton might involve regulation of microtubules, revealing a potential novel role of TUBB2B (show TUBB2B Proteins) and DCDC2 in glomerular podocyte development
This study demonstrated that DCDC2 intron 2 deletion impair illusory visual motion perception-specifically processed by the magnocellular-dorsal (M-D) stream-is impaired in children with Developmental dyslexia.
A nonsynonymous polymorphism in DCDC2 (corrected P = 0.002) and a noncoding variant in S100B (show S100B Proteins) (corrected P = 0.016) showed a significant association with spelling performance in families of German origin.
Our results reveal DCDC2a to be a deafness gene and a player in hair cell kinocilia and supporting cell (show PTPRJ Proteins) primary cilia length regulation likely via its role in microtubule formation and stabilization.
the association of DCDC2 and KIAA0319 (show KIAA0319 Proteins) with Developmental dyslexia in Chinese population should be further validated
In a population carrying a deletion in the DCDC2 gene, impaired motion perception was identified in subjects with dyslexia.
DCDC2 interacts with the mediator of Wnt (show WNT2 Proteins) signaling dishevelled (show DVL2 Proteins), and that DCDC2 overexpression inhibits beta-catenin (show CTNNB1 Proteins)-dependent Wnt (show WNT2 Proteins) signaling; central role of Wnt (show WNT2 Proteins) signaling in the pathogenesis of nephronophthisis-related ciliopathies
An SNP in DCDC2 (rs793842) was significantly associated with the thickness of the left temporoparietal cortex.
This study demonstrated the association of developmental dyslexia with rs4504469 of KIAA0319 (show KIAA0319 Proteins) and not with any single-nucleotide polymorphisms of DCDC2.
Behavioral results revealed deficits in rapid auditory processing, working memory and reference memory in Dcdc2(del2/del2) mice when compared with matched wild types.
Results link the function of the dyslexia-associated gene Dcdc2 to spike timing through activity of N-methyl-D-aspartate receptor (show GRIN1 Proteins) (NMDAR (show GRIN1 Proteins))
These results indicate that Dcdc2 is not required for neurogenesis, neuronal migration or differentiation in mice, but may have partial functional redundancy with doublecortin (show DCX Proteins).
heterozygous and homozygous mutations of Dcdc2 result in persistent visuo-spatial memory deficits, as well as visual discrimination and long-term memory deficits
This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
doublecortin domain containing 2
, doublecortin domain-containing protein 2
, doublecortin domain-containing protein 2-like