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anti-Doublecortin-Like Kinase 1 (DCLK1) Antibodies

DCLK1 encodes a member of the protein kinase superfamily and the doublecortin family. Additionally we are shipping DCLK1 Kits (17) and DCLK1 Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DCLK1 9201 O15075
DCLK1 13175 Q9JLM8
DCLK1 83825 O08875
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Top anti-DCLK1 Antibodies at antibodies-online.com

Showing 10 out of 112 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of DCAMKL1 Antibody (N-term) in mouse brain tissue lysate. DCAMKL1 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DCAMKL1 Antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. The DCAMKL1 Antibody (C-term ) is used in Western blot to detect DCAMKL1 in mouse heart tissue lysate. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of DCAMKL1 Antibody (N-term) (ABIN391323) in mouse brain tissue lysate. DCAMKL1 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. DCAMKL1 Antibody (D13) (ABIN391323) western blot analysis in T47D cell line lysates (35 µg/lane).This demonstrates the DCAMKL1 antibody detected the DCAMKL1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB The DCAMKL1 Antibody (C-term )(ABIN391324) western blot analysis in mouse heart tissuelysates (35 µg/lane).This demonstrates the DCAMKL1 antibody detected the DCAMKL1 protein (arrow). Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DCAMKL1 Antibody (C-term) (ABIN391324), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Immunohistochemistry of DLCK1 in rat brain tissue with DLCK1 antibody at 2.5 μg/ml. Western blot analysis of DCLK1 in human brain tissue lysate with AP30276PU-N DCLK1 antibody at (A) 0.5 and (B) 1 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to DCAMKL1 on NIH/3T3 cell (antibody concentration 10 µg/mL). DCAMKL1 monoclonal antibody (M03), clone 6H4 Western Blot analysis of DCAMKL1 expression in NIH/3T3. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated WB Mouse Dclk1 Antibody (N-term)  western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Dclk1 antibody detected the Dclk1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB DCLK1 Antibody (C-term) (ABIN1881252) western blot analysis in MDA-MB231 cell line lysates (35 µg/lane). This demonstrates the DCLK1 antibody detected the DCLK1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, IHC, WB 400 μL Log in to see 6 Days
$457.14
Details

DCLK1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-DCLK1 Antibodies

  1. Human Polyclonal DCLK1 Primary Antibody for IF, IHC (p) - ABIN391324 : Gerbe, Brulin, Makrini, Legraverend, Jay: DCAMKL-1 expression identifies Tuft cells rather than stem cells in the adult mouse intestinal epithelium. in Gastroenterology 2009 (PubMed)
    Show all 12 references for ABIN391324

  2. Human Polyclonal DCLK1 Primary Antibody for WB - ABIN391323 : Matsumoto, Pilz, Ledbetter: Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS). in Genomics 1999 (PubMed)
    Show all 8 references for ABIN391323

  3. Human Monoclonal DCLK1 Primary Antibody for IF, WB - ABIN393872 : Rose, Behm, Drgon, Johnson, Uhl: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. in Molecular medicine (Cambridge, Mass.) 2010 (PubMed)
    Show all 5 references for ABIN393872

  4. Human Polyclonal DCLK1 Primary Antibody for EIA, WB - ABIN359413 : Sossey-Alaoui, Srivastava: DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX). in Genomics 1999 (PubMed)
    Show all 4 references for ABIN359413

  5. Human Polyclonal DCLK1 Primary Antibody for EIA, WB - ABIN499716 : Ohmae, Takemoto-Kimura, Okamura, Adachi-Morishima, Nonaka, Fuse, Kida, Tanji, Furuyashiki, Arakawa, Narumiya, Okuno, Bito: Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV. in The Journal of biological chemistry 2006 (PubMed)
    Show all 4 references for ABIN499716

  6. Human Polyclonal DCLK1 Primary Antibody for EIA, IHC (p) - ABIN359414 : Omori, Suzuki, Ozaki, Harada, Nakamura, Takahashi, Fujiwara: Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin. in Journal of human genetics 1998 (PubMed)
    Show all 4 references for ABIN359414

More Antibodies against DCLK1 Interaction Partners

Zebrafish Doublecortin-Like Kinase 1 (DCLK1) interaction partners

  1. These results suggest that both the kinase domain and the Ser (show SIGLEC1 Antibodies)/Pro-rich domain are involved in regulating the microtubule-binding activity of doublecortin (show DCX Antibodies)-like protein kinase (show TGFB3 Antibodies) (DCLK (show DCLK2 Antibodies)).

  2. DCLK (show DCLK2 Antibodies) mediates its neuronal functions through phosphorylation of physiological substrates such as synapsin II (show SYN2 Antibodies)

  3. Gene knockdown studies of zDCLK (show DCLK2 Antibodies) suggest that zDCLK (show DCLK2 Antibodies) may play crucial roles in the central nervous systems during the early stage of embryogenesis.

Human Doublecortin-Like Kinase 1 (DCLK1) interaction partners

  1. DCLK1 controls these complex cellular signaling pathways to regulate hepatocellular carcinoma growth, and may be used as a prognostic biomarker.

  2. results provide new insights into the molecular mechanism of the hepatitis B/C-virus induced liver inflammation and tumorigenesis via DCLK1-controlled networks

  3. Data suggest that doublecortin and CaM kinase-like 1 protein short-transcripts (DCLK1-S) may represent an important target for preventing/inhibiting colon-cancers, and for eliminating colon-cancer-stem-cells (CSCs).

  4. DCLK1 is essential for the invasive and metastatic properties of pancreatic cancer stem cells.

  5. Data indicate that doublecortin-like kinase 1 (DCLK1) is overexpressed and has a unique methylation signature in renal clear cell carcinoma (RCC (show XRCC1 Antibodies)).

  6. Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells.

  7. the higher expression level of DCLK1 in patients undergoing CRT (show SLC6A8 Antibodies) can propose it as a more relevant candidate among CSC markers comparing to Lgr5 (show LGR5 Antibodies) for colorectal cancer patients.

  8. Increased expression of DCLK1 was observed in the epithelium, stroma and plasma of patients with Barrett's esophagus and esophageal adenocarcinoma.

  9. Potential exist for DCLK1 as a colorectal cancer biomarker for early detection, but may also have clinical implications regarding the previously proposed therapy toward DCLK1-positive cancer cells.

  10. XMD8-92 treatment results in inhibition of DCLK1 and downstream oncogenic pathways.

Mouse (Murine) Doublecortin-Like Kinase 1 (DCLK1) interaction partners

  1. loss of parietal cells leads to the reversible emergence of a novel Dclk1-expressing sensory cell population in the gastric mucosa.

  2. Dclk1 plays an important role in regulating colonic inflammatory response and colonic epithelial integrity

  3. Dclk1 promotes axonal regeneration, neuronal survival, and growth core reformation via microtubule stabilization, prevention of F-actin destabilization and synergy with mTOR (show FRAP1 Antibodies).

  4. Dclk1 is critically involved in facilitating intestinal tumorigenesis by enhancing pluripotency and EMT (show ITK Antibodies) factors in Apc (show APC Antibodies) mutant intestinal tumors and it also provides a potential therapeutic target for the treatment of colorectal cancer.

  5. Dclk1 plays a functional role critical in the epithelial restorative response.

  6. DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer.

  7. These results suggest that crypt epithelial cell Dclk1 expression can be used as one potential marker to evaluate the early survival of intestinal stem cells following severe radiation injury.

  8. Pancreatic neoplasms in mice contain morphologically and functionally distinct subpopulations, expressing DCLK1, that have cancer stem cell-like properties.

  9. DCAMKL1 represses osteoblast activation by antagonizing Runx2 (show RUNX2 Antibodies), the master transcription factor in osteoblasts.

  10. Doublecortin (show DCX Antibodies)-like kinases are critical regulators of dendritic development by means of their specific targeting to the distal dendrites, and their local control of dendritic growth and synapse maturation.

DCLK1 Antigen Profile

Protein Summary

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.

Gene names and symbols associated with DCLK1

  • doublecortin-like kinase 1 (DCLK1) antibody
  • doublecortin-like kinase 1a (dclk1a) antibody
  • doublecortin-like kinase 2 (dclk2) antibody
  • doublecortin-like kinase 1 (Dclk1) antibody
  • 1700113D08Rik antibody
  • 2810480F11Rik antibody
  • AI836758 antibody
  • Ania4 antibody
  • CL1 antibody
  • Click-I antibody
  • CLICK1 antibody
  • Cpg16 antibody
  • Dcamkl1 antibody
  • DCDC3A antibody
  • Dcl antibody
  • Dclk antibody
  • dclk1 antibody
  • MGC145348 antibody
  • mKIAA0369 antibody
  • wu:fc51f11 antibody
  • zgc:153709 antibody

Protein level used designations for DCLK1

doublecortin-like kinase 1 , doublecortin and CaM kinase-like 1 , doublecortin and calcium/calmodulin-dependent protein kinase-like 1 , serine/threonine-protein kinase DCLK1 , doublecortin-like kinase 2 , serine/threonine-protein kinase DCLK1-like , doublecortin domain-containing protein 3A , doublecortin-like and CAM kinase-like 1 , CLICK-I beta , double cortin and calcium/calmodulin-dependent protein kinase-like 1

GENE ID SPECIES
467259 Pan troglodytes
477304 Canis lupus familiaris
558997 Danio rerio
587664 Strongylocentrotus purpuratus
613449 Bos taurus
733926 Xenopus (Silurana) tropicalis
100401876 Callithrix jacchus
100484701 Ailuropoda melanoleuca
100062396 Equus caballus
100080521 Ornithorhynchus anatinus
100443787 Pongo abelii
100539645 Meleagris gallopavo
100607261 Nomascus leucogenys
9201 Homo sapiens
13175 Mus musculus
83825 Rattus norvegicus
100521679 Sus scrofa
418903 Gallus gallus
100725335 Cavia porcellus
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