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Doublecortin-Like Kinase 2 Proteins (DCLK2)

DCLK2 encodes a member of the protein kinase superfamily and the doublecortin family. Additionally we are shipping Doublecortin-Like Kinase 2 Antibodies (52) and Doublecortin-Like Kinase 2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DCLK2 166614 Q8N568
DCLK2 70762 Q6PGN3
DCLK2 310698 Q5MPA9
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Top Doublecortin-Like Kinase 2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,247.83
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DCLK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Doublecortin-Like Kinase 2 (DCLK2) Interaction Partners

Zebrafish Doublecortin-Like Kinase 2 (DCLK2) interaction partners

  1. the kinase fragment of DCLK is translocated into the nucleus upon hyperosmotic stresses and the kinase efficiently phosphorylates JDP2 (show JDP2 Proteins), a possible target in the nucleus, with the aid of histones

Mouse (Murine) Doublecortin-Like Kinase 2 (DCLK2) interaction partners

  1. Dclk2 promotes axonal regeneration, neuronal survival, and growth core reformation via microtubule stabilization, prevention of F-actin destabilization and synergy with mTOR (show FRAP1 Proteins).

  2. Doublecortin (show DCX Proteins)-like kinases are critical regulators of dendritic development by means of their specific targeting to the distal dendrites, and their local control of dendritic growth and synapse maturation.

  3. Dcx (show DCX Proteins); Dclk2-null mice display frequent spontaneous seizures that originate in the hippocampus, with most animals dying in the first few months of life.

Doublecortin-Like Kinase 2 (DCLK2) Protein Profile

Protein Summary

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.

Gene names and symbols associated with DCLK2

  • doublecortin-like kinase 2 (DCLK2)
  • doublecortin-like kinase 2 (dclk2)
  • doublecortin-like kinase 2 (LOC100339938)
  • doublecortin-like kinase 2 (Dclk2)
  • 6330415M09Rik protein
  • AU044875 protein
  • cb572 protein
  • CL2 protein
  • Click-II protein
  • CLICK2 protein
  • CLIK2 protein
  • Dcamkl2 protein
  • DCDC3 protein
  • DCDC3B protein
  • Dck2 protein
  • dclk protein
  • DCLK2 protein
  • RGD1308384 protein
  • sb:cb572 protein
  • si:dkey-180n16.1 protein

Protein level used designations for DCLK2

doublecortin-like kinase 2 , doublecortin and CaM kinase-like 2 , serine/threonine-protein kinase DCLK2 , zDCLK , CaMK-like CREB regulatory kinase 2 , doublecortin domain-containing protein 3B , doublecortin-like and CAM kinase-like 2 , caMK-like CREB regulatory kinase 2 , doublecortin kinase 2

GENE ID SPECIES
422473 Gallus gallus
461534 Pan troglodytes
482642 Canis lupus familiaris
536110 Bos taurus
572548 Danio rerio
693566 Macaca mulatta
100062533 Equus caballus
100080394 Ornithorhynchus anatinus
100221624 Taeniopygia guttata
100339938 Oryctolagus cuniculus
100356475 Oryctolagus cuniculus
166614 Homo sapiens
70762 Mus musculus
310698 Rattus norvegicus
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