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DCLK2 encodes a member of the protein kinase superfamily and the doublecortin family. Additionally we are shipping Doublecortin-Like Kinase 2 Antibodies (52) and Doublecortin-Like Kinase 2 Kits (1) and many more products for this protein.
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the kinase fragment of DCLK is translocated into the nucleus upon hyperosmotic stresses and the kinase efficiently phosphorylates JDP2 (show JDP2 Proteins), a possible target in the nucleus, with the aid of histones
Dclk2 promotes axonal regeneration, neuronal survival, and growth core reformation via microtubule stabilization, prevention of F-actin destabilization and synergy with mTOR (show FRAP1 Proteins).
Doublecortin (show DCX Proteins)-like kinases are critical regulators of dendritic development by means of their specific targeting to the distal dendrites, and their local control of dendritic growth and synapse maturation.
Dcx (show DCX Proteins); Dclk2-null mice display frequent spontaneous seizures that originate in the hippocampus, with most animals dying in the first few months of life.
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.
doublecortin-like kinase 2
, doublecortin and CaM kinase-like 2
, serine/threonine-protein kinase DCLK2
, CaMK-like CREB regulatory kinase 2
, doublecortin domain-containing protein 3B
, doublecortin-like and CAM kinase-like 2
, caMK-like CREB regulatory kinase 2
, doublecortin kinase 2