anti-Doublecortin-Like Kinase 1 (DCLK1) Antibodies

DCLK1 encodes a member of the protein kinase superfamily and the doublecortin family. Additionally we are shipping DCLK1 Kits (24) and DCLK1 Proteins (17) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DCLK1 9201 O15075
DCLK1 13175 Q9JLM8
DCLK1 83825 O08875
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Top anti-DCLK1 Antibodies at antibodies-online.com

Showing 10 out of 116 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DCAMKL1 Antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. The DCAMKL1 Antibody (C-term ) is used in Western blot to detect DCAMKL1 in mouse heart tissue lysate. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of DCAMKL1 Antibody (N-term) in mouse brain tissue lysate. DCAMKL1 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB The DCAMKL1 Antibody (C-term )(ABIN391324) western blot analysis in mouse heart tissuelysates (35 µg/lane).This demonstrates the DCAMKL1 antibody detected the DCAMKL1 protein (arrow). Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DCAMKL1 Antibody (C-term) (ABIN391324), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of DCAMKL1 Antibody (N-term) (ABIN391323) in mouse brain tissue lysate. DCAMKL1 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. DCAMKL1 Antibody (D13) (ABIN391323) western blot analysis in T47D cell line lysates (35 µg/lane).This demonstrates the DCAMKL1 antibody detected the DCAMKL1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to DCAMKL1 on NIH/3T3 cell (antibody concentration 10 µg/mL). DCAMKL1 monoclonal antibody (M03), clone 6H4 Western Blot analysis of DCAMKL1 expression in NIH/3T3. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Mouse Rabbit Un-conjugated WB Mouse Dclk1 Antibody (N-term)  western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Dclk1 antibody detected the Dclk1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB DCLK1 Antibody (C-term) (ABIN1881252) western blot analysis in MDA-MB231 cell line lysates (35 µg/lane). This demonstrates the DCLK1 antibody detected the DCLK1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ELISA, WB DCAMKL1 monoclonal antibody (M02A), clone 6F9 Western Blot analysis of DCAMKL1 expression in NIH/3T3 . Western Blot detection against Immunogen (35.53 KDa) . 200 μL Log in to see 11 to 12 Days
$430.00
Details

DCLK1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-DCLK1 Antibodies

  1. Human Polyclonal DCLK1 Primary Antibody for IF, IHC (p) - ABIN391324 : Gerbe, Brulin, Makrini, Legraverend, Jay: DCAMKL-1 expression identifies Tuft cells rather than stem cells in the adult mouse intestinal epithelium. in Gastroenterology 2009 (PubMed)
    Show all 12 references for 391324

  2. Human Polyclonal DCLK1 Primary Antibody for WB - ABIN391323 : Matsumoto, Pilz, Ledbetter: Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS). in Genomics 1999 (PubMed)
    Show all 8 references for 391323

  3. Human Monoclonal DCLK1 Primary Antibody for IF, WB - ABIN393872 : Rose, Behm, Drgon, Johnson, Uhl: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. in Molecular medicine (Cambridge, Mass.) 2010 (PubMed)
    Show all 5 references for 393872

  4. Human Polyclonal DCLK1 Primary Antibody for EIA, WB - ABIN359413 : Sossey-Alaoui, Srivastava: DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX). in Genomics 1999 (PubMed)
    Show all 4 references for 359413

  5. Human Polyclonal DCLK1 Primary Antibody for EIA, IHC (p) - ABIN359414 : Omori, Suzuki, Ozaki, Harada, Nakamura, Takahashi, Fujiwara: Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin. in Journal of human genetics 1998 (PubMed)
    Show all 4 references for 359414

More Antibodies against DCLK1 Interaction Partners

Zebrafish Doublecortin-Like Kinase 1 (DCLK1) interaction partners

  1. These results suggest that both the kinase domain and the Ser (show SIGLEC1 Antibodies)/Pro-rich domain are involved in regulating the microtubule-binding activity of doublecortin (show DCX Antibodies)-like protein kinase (show TGFB3 Antibodies) (DCLK (show DCLK2 Antibodies)).

  2. DCLK (show DCLK2 Antibodies) mediates its neuronal functions through phosphorylation of physiological substrates such as synapsin II (show SYN2 Antibodies)

  3. Gene knockdown studies of zDCLK (show DCLK2 Antibodies) suggest that zDCLK (show DCLK2 Antibodies) may play crucial roles in the central nervous systems during the early stage of embryogenesis.

Human Doublecortin-Like Kinase 1 (DCLK1) interaction partners

  1. Our results indicate that Dclk1 is essential in advancing intestinal tumorigenesis. Knocking down Dclk1 decreases tumor stemness and progression and is thus predicted to regulate pro-survival signaling and tumor cell pluripotency.

  2. The univariate and multivariate analyses suggested DCAMKL1 protein overexpression was an unfavorable prognostic factor in bladder cancer patients. In conclusion, DCAMKL1 is an independent poor prognostic factor for bladder cancer patients.

  3. DCLK1 induction and its overexpression following hepatic injury are likely to contribute to tumorigenesis including maintenance and dissemination of tumor cells in circulation.

  4. first evidence for the suppressive activity of miR (show MLXIP Antibodies)-613 in hepatocellular carcinoma, which is causally linked to targeting of DCLK1

  5. MSX1 (show MSX1 Antibodies) and DCLK1 might be used in colorectal cancer detection or as target of cancer therapies.

  6. Increased expression of stromal DCLK1 was detected in endometriotic tissue compared to endometriosis patient endometrium. Stromal expression of DCLK1 was increased in endometrium of endometriosis patients compared to controls.

  7. DCLK1 up-regulation may play a contributory role in colorectal cancer metastasis and poor prognosis via activation of EMT (show ITK Antibodies). DCLK1 may serve as an independent predictor for CRC (show CALR Antibodies) prognosis.

  8. Results showed the mechanism in which miR (show MLXIP Antibodies)-137 regulates the expression of DCLK1, and demonstrated the opposite expression patterns of miR (show MLXIP Antibodies)-137/DCLK1 in human non-small cell lung carcinoma and colon cancer stem cells.

  9. DCLK1 promoter methylationis associated with lung cancer.

  10. DCLK1 expression could aid in the prognostication and management of breast cancer with neuroendocrine differentiation.

Mouse (Murine) Doublecortin-Like Kinase 1 (DCLK1) interaction partners

  1. Dclk1 contributes functionally to the pathogenesis of pancreatic cancer; Dclk1 marks quiescent pancreatic progenitors that are candidates for the origin of pancreatic cancer

  2. loss of parietal cells leads to the reversible emergence of a novel Dclk1-expressing sensory cell population in the gastric mucosa.

  3. Dclk1 plays an important role in regulating colonic inflammatory response and colonic epithelial integrity

  4. Dclk1 promotes axonal regeneration, neuronal survival, and growth core reformation via microtubule stabilization, prevention of F-actin destabilization and synergy with mTOR (show FRAP1 Antibodies).

  5. Dclk1 is critically involved in facilitating intestinal tumorigenesis by enhancing pluripotency and EMT (show ITK Antibodies) factors in Apc (show APC Antibodies) mutant intestinal tumors and it also provides a potential therapeutic target for the treatment of colorectal cancer.

  6. Dclk1 plays a functional role critical in the epithelial restorative response.

  7. DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer.

  8. These results suggest that crypt epithelial cell Dclk1 expression can be used as one potential marker to evaluate the early survival of intestinal stem cells following severe radiation injury.

  9. Pancreatic neoplasms in mice contain morphologically and functionally distinct subpopulations, expressing DCLK1, that have cancer stem cell-like properties.

  10. DCAMKL1 represses osteoblast activation by antagonizing Runx2 (show RUNX2 Antibodies), the master transcription factor in osteoblasts.

DCLK1 Antigen Profile

Protein Summary

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.

Gene names and symbols associated with DCLK1

  • doublecortin-like kinase 1 (DCLK1) antibody
  • doublecortin-like kinase 1a (dclk1a) antibody
  • doublecortin-like kinase 2 (dclk2) antibody
  • doublecortin-like kinase 1 (Dclk1) antibody
  • 1700113D08Rik antibody
  • 2810480F11Rik antibody
  • AI836758 antibody
  • Ania4 antibody
  • CL1 antibody
  • Click-I antibody
  • CLICK1 antibody
  • Cpg16 antibody
  • Dcamkl1 antibody
  • DCDC3A antibody
  • Dcl antibody
  • Dclk antibody
  • dclk1 antibody
  • MGC145348 antibody
  • mKIAA0369 antibody
  • wu:fc51f11 antibody
  • zgc:153709 antibody

Protein level used designations for DCLK1

doublecortin-like kinase 1 , doublecortin and CaM kinase-like 1 , doublecortin and calcium/calmodulin-dependent protein kinase-like 1 , serine/threonine-protein kinase DCLK1 , doublecortin-like kinase 2 , serine/threonine-protein kinase DCLK1-like , doublecortin domain-containing protein 3A , doublecortin-like and CAM kinase-like 1 , CLICK-I beta , double cortin and calcium/calmodulin-dependent protein kinase-like 1

GENE ID SPECIES
467259 Pan troglodytes
477304 Canis lupus familiaris
558997 Danio rerio
587664 Strongylocentrotus purpuratus
613449 Bos taurus
733926 Xenopus (Silurana) tropicalis
100401876 Callithrix jacchus
100484701 Ailuropoda melanoleuca
100062396 Equus caballus
100080521 Ornithorhynchus anatinus
100443787 Pongo abelii
100539645 Meleagris gallopavo
100607261 Nomascus leucogenys
9201 Homo sapiens
13175 Mus musculus
83825 Rattus norvegicus
100521679 Sus scrofa
418903 Gallus gallus
100725335 Cavia porcellus
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