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Down Syndrome Cell Adhesion Molecule Proteins (DSCAM)

DSCAM is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs), and is involved in human central and peripheral nervous system development. Additionally we are shipping DSCAM Antibodies (43) and DSCAM Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DSCAM 1826 O60469
DSCAM 13508 Q9ERC8
Rat DSCAM DSCAM 171119 Q8VHZ8
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Top DSCAM Proteins at antibodies-online.com

Showing 3 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

DSCAM Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Down Syndrome Cell Adhesion Molecule (DSCAM) Interaction Partners

Zebrafish Down Syndrome Cell Adhesion Molecule (DSCAM) interaction partners

  1. Migrating cells utilize dscam to remodel the developing embryo

Fruit Fly (Drosophila melanogaster) Down Syndrome Cell Adhesion Molecule (DSCAM) interaction partners

  1. Studies suggest that the somatic mutually alternative splicing within a single gene may offer a simplified way of expressing a large Dscam repertoire.

  2. Protein production, crystallization and preliminary crystallographic analysis of the four N-terminal immunoglobulin domains of Dscam1 has been reported.

  3. Dysregulated Dscam binds to Abl through its cytoplasmic domain to enlarge presynaptic arbors in the Drosophila fragile X (show FMR1 Proteins) syndrome model.

  4. As thousands of Dscam isoforms are needed for the self-avoidance of the neuron, we propose that an increase in self-binding affinity provides the basis for the successful evolution of the arthropod brain

  5. Manipulation of the Dscam1 isoform pool in single neurons caused severe disruption of collateral formation of mechanosensory axons.

  6. The data of this study suggested that Dscam1 is required cell autonomously for normal adult motoneuron dendrite growth in Drosophila.

  7. Dscam1 splicing is probabilistic through the analysis of alternative exon 4 expression using splicing reporters; widespread probabilistic splicing supports a role for Dscam1 diversity in self-recognition throughout the developing nervous system.

  8. The found uncover a function of Dscam in presynaptic size control and provide insights into how dysregulated Dscam may contribute to the pathogenesis of neurological disorders.

  9. Excess Dscam protein may be a common molecular mechanism underlying altered neural wiring in intellectual disabilities such as fragile X (show FMR1 Proteins) and Down syndromes.

  10. The data of this study deministrated that recognition between Dscam1 isoforms on neurites of the same cell provides the molecular basis for self-avoidance.

Human Down Syndrome Cell Adhesion Molecule (DSCAM) interaction partners

  1. Our study did not repeatedly confirm the association of the rs2222973 or the rs11770843 SNP with adolescent idiopathic scoliosis in a Chinese Han population.

  2. The most significant was DSCAM, a neurological gene expressed widely in the developing brain and in the amygdala and hippocampus of the adult brain.

  3. DSCAM physically interacts with tubulin folding cofactor D (show TBCD Proteins).

  4. DSCAM as a Hirschsprung disease (HSCR (show EDNRB Proteins)) susceptibility locus, both in Down syndrome and HSCR (show EDNRB Proteins) isolated cases.

  5. Down syndrome cell adhesion molecule interacts with PRKAG1 (show PRKAG1 Proteins) subunit and plays an important role in netrin-1 (show NTN1 Proteins) induced neurite outgrowth.

  6. knockdown of DSCAM inhibits netrin-induced tyrosine phosphorylation of UNC5C (show Unc5c Proteins) and Fyn (show FYN Proteins) as well as the interaction of UNC5C (show Unc5c Proteins) with Fyn (show FYN Proteins). The double knockdown of both receptors abolishes the induction of Fyn (show FYN Proteins) tyrosine phosphorylation by netrin-1 (show NTN1 Proteins)

  7. The specificity of Drosophila Dscam is due to complementarity of variable residues in epitope I.

  8. Overall, our study found a significant association of IL-17RC (show IL17RC Proteins) gene polymorphisms with AIS (show AR Proteins) in a Chinese Han population, indicating IL-17RC (show IL17RC Proteins) gene may be as a susceptibility gene for AIS (show AR Proteins).

  9. Dscam may be involved in the generation and development of intractable epilepsy.

  10. functionally conserved with Drosophila Dscam[TM1 (show TPM2 Proteins)] isoforms

Mouse (Murine) Down Syndrome Cell Adhesion Molecule (DSCAM) interaction partners

  1. Results suggest that down syndrome cell adhesion molecule collaborates with deleted in colorectal cancer (show DCC Proteins) to regulate microtubule dynamics via direct binding to dynamic TUBB3 (show TUBB3 Proteins) in Netrin-1 (show NTN1 Proteins)-induced axon branching.

  2. Our results indicate an important role of DSCAM and DSCAML1 (show DSCAML1 Proteins) in the development of cortical neural network.

  3. DSCAM colocalizes in developmentally dynamic patterns with adhesion and synaptic proteins in the mouse retina.

  4. The findings of this study are as follows: (1) DSCAM is sufficient to drive cell death (2) dendrite avoidance defects in the Dscam loss-of-function retina do not reflect a role for DSCAM, and necessary and sufficient to target neurites.

  5. A novel splice isoform of Dscam causes defects in lamination of type 2 and type 6 cone bipolar cells in Dscam mutant mice.

  6. DSCAM contributes to pyramidal neuron morphogenesis by regulating dendrite arborization and spine formation during cortical circuit development

  7. somal clustering and fasciculation observed in the Dscam mutant retina are not unique to Dscam deficiency and are manifested distinctively by different retinal cell types.

  8. Data indicate that the mammalian DSCAM gene is critical for the formation of the central nervous system.

  9. DSCAM is not required for Netrin-induced commissural axon outgrowth and guidance in mice.

  10. Deletion of Dscam in specific cell types causes cell-type-autonomous cell body spacing defects, indicating that DSCAM mediates arborization and spacing by acting within given cell types.

DSCAM Protein Profile

Protein Summary

This gene is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs), and is involved in human central and peripheral nervous system development. This gene is a candidate for Down syndrome and congenital heart disease (DSCHD). A gene encoding a similar Ig-CAM protein is located on chromosome 11. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with DSCAM

  • Down syndrome cell adhesion molecule (DSCAM)
  • Down syndrome cell adhesion molecule (Dscam)
  • Down syndrome cell adhesion molecule (dscam)
  • Down syndrome cell adhesion molecule a (dscama)
  • down syndrome cell adhesion molecule (AaeL_AAEL010606)
  • down syndrome cell adhesion molecule (CpipJ_CPIJ006173)
  • 43Bc protein
  • 4932410A21Rik protein
  • CG17800 protein
  • CHD2-42 protein
  • CHD2-52 protein
  • CT39257 protein
  • DmDscam protein
  • Dmel\\CG17800 protein
  • Dm_2R:13612 protein
  • dScam protein
  • Dscam-hv protein
  • Dscam1 protein
  • FBgn0033159 protein
  • GB15141 protein
  • l(2)05518 protein
  • l(2)43Bc protein
  • Neu1 protein
  • p270 protein

Protein level used designations for DSCAM

Down syndrome cell adhesion molecule , CG17800-PA , CG17800-PAA , CG17800-PAB , CG17800-PAC , CG17800-PAD , CG17800-PAE , CG17800-PAF , CG17800-PAG , CG17800-PAH , CG17800-PAI , CG17800-PAJ , CG17800-PAK , CG17800-PAL , CG17800-PAM , CG17800-PAN , CG17800-PAO , CG17800-PAP , CG17800-PAQ , CG17800-PAR , CG17800-PAS , CG17800-PAT , CG17800-PAU , CG17800-PAV , CG17800-PAW , CG17800-PAX , CG17800-PAY , CG17800-PAZ , CG17800-PBA , CG17800-PBB , CG17800-PBC , CG17800-PBD , CG17800-PBE , CG17800-PBF , CG17800-PBG , CG17800-PBH , CG17800-PBI , CG17800-PBJ , CG17800-PBK , CG17800-PBL , CG17800-PBM , CG17800-PBN , CG17800-PBO , CG17800-PBP , CG17800-PBQ , CG17800-PBR , CG17800-PBS , CG17800-PBT , CG17800-PBU , CG17800-PBV , CG17800-PBW , CG17800-PBX , CG17800-PBY , CG17800-PBZ , CG17800-PC , CG17800-PCA , CG17800-PCB , CG17800-PCC , CG17800-PCD , CG17800-PD , CG17800-PE , CG17800-PF , CG17800-PG , CG17800-PH , CG17800-PI , CG17800-PJ , CG17800-PL , CG17800-PM , CG17800-PO , CG17800-PR , CG17800-PT , CG17800-PV , CG17800-PW , CG17800-PX , CG17800-PY , CG17800-PZ , Down's syndrome cell adhesion molecule , Dscam-PA , Dscam-PAA , Dscam-PAB , Dscam-PAC , Dscam-PAD , Dscam-PAE , Dscam-PAF , Dscam-PAG , Dscam-PAH , Dscam-PAI , Dscam-PAJ , Dscam-PAK , Dscam-PAL , Dscam-PAM , Dscam-PAN , Dscam-PAO , Dscam-PAP , Dscam-PAQ , Dscam-PAR , Dscam-PAS , Dscam-PAT , Dscam-PAU , Dscam-PAV , Dscam-PAW , Dscam-PAX , Dscam-PAY , Dscam-PAZ , Dscam-PBA , Dscam-PBB , Dscam-PBC , Dscam-PBD , Dscam-PBE , Dscam-PBF , Dscam-PBG , Dscam-PBH , Dscam-PBI , Dscam-PBJ , Dscam-PBK , Dscam-PBL , Dscam-PBM , Dscam-PBN , Dscam-PBO , Dscam-PBP , Dscam-PBQ , Dscam-PBR , Dscam-PBS , Dscam-PBT , Dscam-PBU , Dscam-PBV , Dscam-PBW , Dscam-PBX , Dscam-PBY , Dscam-PBZ , Dscam-PC , Dscam-PCA , Dscam-PCB , Dscam-PCC , Dscam-PCD , Dscam-PD , Dscam-PE , Dscam-PF , Dscam-PG , Dscam-PH , Dscam-PI , Dscam-PJ , Dscam-PL , Dscam-PM , Dscam-PO , Dscam-PR , Dscam-PT , Dscam-PV , Dscam-PW , Dscam-PX , Dscam-PY , Dscam-PZ , down syndrome cell adhesion molecule , down syndrome cell-adhesion molecule , drosophila down syndrome cell adhesion molecule , drosophila down syndrome cell adhesion molecule 1 , lethal(2)43Bc , down syndrome cell adhesion molecule-like , CHD2 , human CHD2-52 down syndrome cell adhesion molecule , Down syndrome cell adhesion molecule homolog

GENE ID SPECIES
100058783 Equus caballus
652946 Tribolium castaneum
722556 Macaca mulatta
100216449 Xenopus (Silurana) tropicalis
747803 Pan troglodytes
568643 Danio rerio
514757 Bos taurus
408786 Apis mellifera
35652 Drosophila melanogaster
5573626 Aedes aegypti
6037737 Culex quinquefasciatus
100401724 Callithrix jacchus
100553114 Anolis carolinensis
100604423 Nomascus leucogenys
1826 Homo sapiens
487768 Canis lupus familiaris
13508 Mus musculus
171119 Rattus norvegicus
735085 Xenopus laevis
418525 Gallus gallus
100337016 Bos taurus
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