Dpy-19-Like 2 (C. Elegans) (DPY19L2) ELISA Kits

The protein encoded by DPY19L2 belongs to the dpy-19 family. Additionally we are shipping Dpy-19-Like 2 (C. Elegans) Antibodies (40) and Dpy-19-Like 2 (C. Elegans) Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human DPY19L2 DPY19L2 283417 Q6NUT2
Anti-Rat DPY19L2 DPY19L2 300461  
Anti-Mouse DPY19L2 DPY19L2 320752 P0CW70
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More ELISA Kits for Dpy-19-Like 2 (C. Elegans) Interaction Partners

Human Dpy-19-Like 2 (C. Elegans) (DPY19L2) interaction partners

  1. Patients presenting with a monomorphic teratozoospermia such as globozoospermia or macrospermia with more than 85% of the spermatozoa presenting this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC (show AURKC ELISA Kits) and DPY19L2.

  2. Among Tunisian patients with globozoospermia, 8 DPY19L2 haplotypes were found. 61.1% were homozygous for a DPY19L2 deletion. A new splice-site mutation at the junction exon-intron 16 [c.1579_1580+4delAGGTAAinsTCAT] was found in 1 patient.

  3. The DPY19L2 mutations are the major cause of globozoospermia.

  4. Analysis of public databases at the DPY19L2 locus paradoxically revealed that, in the general population, duplications were approximately three times as frequent as deletions.

  5. DPY19L2 is the major gene responsible for globozoospermia and enlarges the spectrum of possible mutations in the gene.

  6. identification of DPY19L2 deletions and point mutations in European patients shows that globozoospemia caused by a molecular defect of DPY19L2 can be expected in individuals from any ethnic background

  7. Patients with globozoospermia have a homozygous deletion of DPY19L2.

  8. The relocation of the gene DPY19L2 within a set of low copy repeats.

Mouse (Murine) Dpy-19-Like 2 (C. Elegans) (DPY19L2) interaction partners

  1. In Dpy19l2 knock-out round spermatids, the detachment of the acrosome leads to Sun5 and lamin B1 relocalization, confirming that Sun5 protein is excluded from the nuclear envelope facing the acrosome.

  2. Absence of Dpy19l2 leads to the destabilization of both the nuclear dense lamina and the junction between the acroplaxome and the nuclear envelope in spermatids. Consequently, the acrosome and the manchette fail to be linked to the nucleus.

Dpy-19-Like 2 (C. Elegans) (DPY19L2) Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the dpy-19 family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9).

Gene names and symbols associated with DPY19L2

  • dpy-19-like 2 (C. elegans) (DPY19L2) antibody
  • dpy-19-like 2 (C. elegans) (Dpy19l2) antibody
  • probable C-mannosyltransferase DPY19L2-like (LOC524676) antibody
  • 4932443J21Rik antibody
  • DPY19L2 antibody
  • Dyp19l2 antibody
  • Gm18376 antibody
  • RGD1564311 antibody
  • SPATA34 antibody
  • SPGF9 antibody

Protein level used designations for DPY19L2

dpy-19-like 2 (C. elegans) , protein dpy-19 homolog 2-like , probable C-mannosyltransferase DPY19L2 , protein dpy-19 homolog 2 , spermatogenesis associated 34 , dpy-19-like protein 2 , dpy-19-like 2

709323 Macaca mulatta
745265 Pan troglodytes
100394039 Callithrix jacchus
100460030 Pongo abelii
100468662 Ailuropoda melanoleuca
283417 Homo sapiens
300461 Rattus norvegicus
320752 Mus musculus
475282 Canis lupus familiaris
100524658 Sus scrofa
524676 Bos taurus
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