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May act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K.. Additionally we are shipping DAPP1 Kits (9) and DAPP1 Proteins (6) and many more products for this protein.
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Human Polyclonal DAPP1 Primary Antibody for ELISA, WB - ABIN308258
Marshall, Niiro, Lerner, Yun, Thomas, Disteche, Clark: A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase. in The Journal of experimental medicine 2000
These data show that Bam32 is important for optimal anti-trypanosome IgG antibody response and suppression of disease-promoting proinflammatory cytokines.
our results identify Bam32 as a novel regulator of mast cell activation
Bam32 serves to integrate PI3K and Src kinase (show CSK Antibodies) signaling to promote Rac (show AKT1 Antibodies)-dependent B cell adhesive interactions important for Ag presentation function.
The interaction of Bam32 with Lyn (show LYN Antibodies) leads to Bam32 phosphorylation, which might play an important role in activating downstream signaling molecules.
Data show that Erk (show EPHB2 Antibodies) activation was diminished in LAT (show LAT Antibodies) knock-in Bam32 knockout CD4 (show CD4 Antibodies)(+) T cells.
Bam32 is not required for germinal center (GC) initiation, but rather functions in a late checkpoint of GC progression associated with T cell recruitment and GC B (show NPR2 Antibodies) cell survival.
we propose a role for Bam32 in the signaling of MHC class I molecules in professional Ag-presenting DC for the regulation of CD8 (show CD8A Antibodies)(+) T cell activation.
novel phosphorylation-dependent function of Bam32 in regulating Rac1 activation and actin remodeling.
BAM32 works downstream of Src (show SRC Antibodies) family protein tyrosine kinases and functions to link B cell antigen receptor signals with antigen-processing pathways in B cells.
May act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K.
dual adaptor of phosphotyrosine and 3-phosphoinositides
, dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
, B-cell adapter molecule of 32 kDa
, b lymphocyte adapter protein Bam32
, dual adaptor for phosphotyrosine and 3-phosphoinositides 1