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May act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K.. Additionally we are shipping DAPP1 Antibodies (100) and DAPP1 Kits (9) and many more products for this protein.
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These data show that Bam32 is important for optimal anti-trypanosome IgG antibody response and suppression of disease-promoting proinflammatory cytokines.
our results identify Bam32 as a novel regulator of mast cell activation
Bam32 serves to integrate PI3K and Src kinase (show CSK Proteins) signaling to promote Rac (show AKT1 Proteins)-dependent B cell adhesive interactions important for Ag presentation function.
The interaction of Bam32 with Lyn (show LYN Proteins) leads to Bam32 phosphorylation, which might play an important role in activating downstream signaling molecules.
Data show that Erk (show EPHB2 Proteins) activation was diminished in LAT (show LAT Proteins) knock-in Bam32 knockout CD4 (show CD4 Proteins)(+) T cells.
Bam32 is not required for germinal center (GC) initiation, but rather functions in a late checkpoint of GC progression associated with T cell recruitment and GC B (show NPR2 Proteins) cell survival.
we propose a role for Bam32 in the signaling of MHC class I molecules in professional Ag-presenting DC for the regulation of CD8 (show CD8A Proteins)(+) T cell activation.
novel phosphorylation-dependent function of Bam32 in regulating Rac1 activation and actin remodeling.
BAM32 works downstream of Src (show SRC Proteins) family protein tyrosine kinases and functions to link B cell antigen receptor signals with antigen-processing pathways in B cells.
May act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K.
dual adaptor of phosphotyrosine and 3-phosphoinositides
, dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
, B-cell adapter molecule of 32 kDa
, b lymphocyte adapter protein Bam32
, dual adaptor for phosphotyrosine and 3-phosphoinositides 1