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Dual Oxidase 1 Proteins (DUOX1)

The protein encoded by DUOX1 is a glycoprotein and a member of the NADPH oxidase family. Additionally we are shipping DUOX1 Antibodies (31) and DUOX1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DUOX1 53905 Q9NRD9
Mouse DUOX1 DUOX1 99439  
Rat DUOX1 DUOX1 266807 Q8CIY2
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Top DUOX1 Proteins at antibodies-online.com

Showing 4 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DUOX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,

More Proteins for Dual Oxidase 1 (DUOX1) Interaction Partners

Purple Sea Urchin (Strongylocentrotus purpuratus) Dual Oxidase 1 (DUOX1) interaction partners

  1. dual oxidase Udx1 has a role in the oxidative burst at fertilization

Zebrafish Dual Oxidase 1 (DUOX1) interaction partners

  1. The results reveal a crucial role for TNFalpha (show TNF Proteins)/TNFR2 (show TNFRSF1B Proteins) axis in the protection of the skin against DUOX1-mediated oxidative stress.

  2. extracellular ATP acting as an early danger signal is responsible for the activation of Duox1 via a P2YR/PLC (show PLC Proteins)/Ca(2 (show CA2 Proteins)+) signaling pathway and the production of H2O2

  3. Zebrafish duox is highly expressed in intestinal epithelial cells. Knockdown of Duox impaired larval capacity to control enteric Salmonella infection.

Human Dual Oxidase 1 (DUOX1) interaction partners

  1. These data reveal a key role of DUOX1-dependent hydrogen peroxide production in long-term persistent radio-induced DNA damage.

  2. Studies demonstrate the importance of DUOX1 in epithelial redox signaling through reversible S-glutathionylation of a range of proteins, including proteins involved in cytoskeletal regulation and MAPK (show MAPK1 Proteins) signaling pathways involved in cell migration.

  3. Duox2 (show DUOX2 Proteins) proteins possessing the A-loops of Nox1 (show NOX1 Proteins) or Nox5 (show NOX5 Proteins) co-expressed with DuoxA2 (show DUOXA2 Proteins) showed enhanced O2 () release, and Duox1 proteins possessing the A-loops of Nox1 (show NOX1 Proteins) or Nox5 (show NOX5 Proteins) co-expressed with DuoxA1 (show DUOXA1 Proteins) acquired O2 () leakage

  4. DUOX1 is the major H2O2-producing source in NHKs stimulated with Ca(2 (show CA2 Proteins)+), and plays a significant role in regulating the expression of specific markers necessary for the normal differentiation of keratinocytes

  5. Further, ROS (show ROS1 Proteins) generated by Duox enzymes localized adjacent to nuclear speckles altered the splicing of viral genes

  6. Despite the high sequence similarity shared between DUOX1 and DUOX2 (show DUOX2 Proteins), the two isoforms present distinct regulations, tissue expression and catalytic functions

  7. Duox1 activity is stimulated by testosterone through GPRC6A in skin keratinocytes

  8. Underscore the importance of DUOX1 and DUOX2 (show DUOX2 Proteins) in vesicant-induced IL-6 (show IL6 Proteins) secretion in human airway epithelial cells.

  9. PA-LPS (show IRF6 Proteins)-induced MUC5AC and Clca3 expression is partly through Duox1

  10. DUOX1 plays a central role in epithelial defense responses to infection or injury, by mediating oxidative activation of Src (show SRC Proteins) and ADAM17 (show ADAM17 Proteins) in response to ATP-dependent P2Y (show P2RY1 Proteins)(2)R activation as a proximal step in EGFR (show EGFR Proteins) transactivation and downstream signaling.

Mouse (Murine) Dual Oxidase 1 (DUOX1) interaction partners

  1. findings suggest that LPS (show TLR4 Proteins)-TLR-4 (show TLR4 Proteins)-induced KC or MIP-2 (show CXCL2 Proteins) cytokine induction and subsequent neutrophil recruitment in the airway does not require DUOX-derived hydrogen peroxide from airway epithelium

  2. These findings suggest that DUOX-derived H2O2 has an important role in signaling neutrophils into allergic airways

  3. Studies demonstrate the importance of DUOX1 in epithelial redox signaling through reversible S-glutathionylation of a range of proteins, including proteins involved in cytoskeletal regulation and MAPK (show MAPK1 Proteins) signaling pathways involved in cell migration.

  4. PA-LPS (show TLR4 Proteins)-induced MUC5AC and Clca3 expression is partly through Duox1

  5. In vivo DUOX1 silencing significantly suppressed naphthalene-induced activation of STAT3 (show STAT3 Proteins).

  6. Urothelial cells produce hydrogen peroxide through the activation of Dual oxidase 1

  7. Duox1 is the main source of H(2)O(2) in the rat thyroid cell line PCCl3.

DUOX1 Protein Profile

Protein Summary

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

Gene names and symbols associated with Dual Oxidase 1 Proteins (DUOX1)

  • dual oxidase 1 (duox1)
  • dual oxidase 1 (DUOX1)
  • dual oxidase (duox)
  • dual oxidase 1 (AaeL_AAEL007563)
  • dual oxidase 1 (Duox1)
  • 9930101G15Rik protein
  • AW987690 protein
  • duox1 protein
  • Duox2 protein
  • LNOX1 protein
  • LNOX2 protein
  • NOXEF1 protein
  • NOXEF2 protein
  • P138-TOX protein
  • THOX1 protein
  • THOX2 protein
  • Udx1 protein

Protein level used designations for Dual Oxidase 1 Proteins (DUOX1)

dual oxidase 1 , NADPH thyroid oxidase 1 , flavoprotein NADPH oxidase , large NOX 1 , long NOX 1 , nicotinamide adenine dinucleotide phosphate oxidase , thyroid oxidase 1 , dual oxidase 2

GENE ID SPECIES
588656 Strongylocentrotus purpuratus
100012836 Monodelphis domestica
467673 Pan troglodytes
565097 Danio rerio
5569378 Aedes aegypti
53905 Homo sapiens
99439 Mus musculus
266807 Rattus norvegicus
403720 Canis lupus familiaris
397177 Sus scrofa
510409 Bos taurus
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