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The protein encoded by DUOX1 is a glycoprotein and a member of the NADPH oxidase family. Additionally we are shipping DUOX1 Proteins (7) and DUOX1 Kits (5) and many more products for this protein.
Showing 10 out of 35 products:
Human Polyclonal DUOX1 Primary Antibody for IHC (p), IHC - ABIN449366
Kippner, Finn, Shukla, Kemp: Systemic remodeling of the redox regulatory network due to RNAi perturbations of glutaredoxin 1, thioredoxin 1, and glucose-6-phosphate dehydrogenase. in BMC systems biology 2011
Show all 3 references for ABIN449366
Polyclonal DUOX1 Primary Antibody for ELISA - ABIN263200
Harper, Xu, Eiserich, Chen, Kao, Thai, Setiadi, Wu: Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. in FEBS letters 2005
dual oxidase Udx1 has a role in the oxidative burst at fertilization
The results reveal a crucial role for TNFalpha (show TNF Antibodies)/TNFR2 (show TNFRSF1B Antibodies) axis in the protection of the skin against DUOX1-mediated oxidative stress.
extracellular ATP acting as an early danger signal is responsible for the activation of Duox1 via a P2YR/PLC (show PLC Antibodies)/Ca(2 (show CA2 Antibodies)+) signaling pathway and the production of H2O2
Zebrafish duox is highly expressed in intestinal epithelial cells. Knockdown of Duox impaired larval capacity to control enteric Salmonella infection.
Cox (show COX8A Antibodies) multivariate regression analysis demonstrated that DUOX1, GLS2 (show GLS2 Antibodies), FBP1 (show FBP1 Antibodies) and age were independent risk factors for the prognosis of HCC (show FAM126A Antibodies) patients after surgery
DUOX1 expression in liver tumors is a potential prognostic tool for patients.
Nox4 (show NOX4 Antibodies) and Duox1/Duox2 mediate redox activation of mesenchymal cell migration by PDGF (show PDGFA Antibodies).
These data reveal a key role of DUOX1-dependent hydrogen peroxide production in long-term persistent radio-induced DNA damage.
Studies demonstrate the importance of DUOX1 in epithelial redox signaling through reversible S-glutathionylation of a range of proteins, including proteins involved in cytoskeletal regulation and MAPK (show MAPK1 Antibodies) signaling pathways involved in cell migration.
Duox2 (show DUOX2 Antibodies) proteins possessing the A-loops of Nox1 (show NOX1 Antibodies) or Nox5 (show NOX5 Antibodies) co-expressed with DuoxA2 (show DUOXA2 Antibodies) showed enhanced O2 () release, and Duox1 proteins possessing the A-loops of Nox1 (show NOX1 Antibodies) or Nox5 (show NOX5 Antibodies) co-expressed with DuoxA1 (show DUOXA1 Antibodies) acquired O2 () leakage
DUOX1 is the major H2O2-producing source in NHKs stimulated with Ca(2 (show CA2 Antibodies)+), and plays a significant role in regulating the expression of specific markers necessary for the normal differentiation of keratinocytes
Further, ROS (show ROS1 Antibodies) generated by Duox enzymes localized adjacent to nuclear speckles altered the splicing of viral genes
Despite the high sequence similarity shared between DUOX1 and DUOX2 (show DUOX2 Antibodies), the two isoforms present distinct regulations, tissue expression and catalytic functions
Duox1 activity is stimulated by testosterone through GPRC6A (show GPRC6A Antibodies) in skin keratinocytes
findings suggest that LPS (show TLR4 Antibodies)-TLR-4 (show TLR4 Antibodies)-induced KC or MIP-2 (show CXCL2 Antibodies) cytokine induction and subsequent neutrophil recruitment in the airway does not require DUOX-derived hydrogen peroxide from airway epithelium
These findings suggest that DUOX-derived H2O2 has an important role in signaling neutrophils into allergic airways
PA-LPS (show TLR4 Antibodies)-induced MUC5AC and Clca3 (show CLCA3P Antibodies) expression is partly through Duox1
In vivo DUOX1 silencing significantly suppressed naphthalene-induced activation of STAT3 (show STAT3 Antibodies).
Urothelial cells produce hydrogen peroxide through the activation of Dual oxidase 1
Duox1 is the main source of H(2)O(2) in the rat thyroid cell line PCCl3.
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
dual oxidase 1
, NADPH thyroid oxidase 1
, flavoprotein NADPH oxidase
, large NOX 1
, long NOX 1
, nicotinamide adenine dinucleotide phosphate oxidase
, thyroid oxidase 1
, dual oxidase 2