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DUOXA2 encodes an endoplasmic reticulum protein that is necessary for proper cellular localization and maturation of functional dual oxidase 2. Additionally we are shipping DUOXA2 Proteins (4) and many more products for this protein.
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inactivating mutations in the DUOXA2 (p.Y246X) and DUOX2 (show DUOX2 Antibodies) (p.R885Q) genes were identified in a set of dizygotic twins with congenital hypothyroidism
The folding of DUOX2 (show DUOX2 Antibodies) appears to be a key event in the trafficking of the DUOX2 (show DUOX2 Antibodies)/DUOXA2 complex as it promotes an appropriate conformation of the N-terminal region, which is propitious to subsequent covalent interactions with the maturation factor, DUOXA2.
a novel DUOXA2 mutation (I26M) causing congenital hypothyroidism with goiter, which affected H2O2 generation but did not alter the protein expression levels, further confirming the essential role of DUOXA2 in thyroid hormone (show PTH Antibodies) synthesis.
The DUOX (show DUOX1 Antibodies)-expressing model, the human intestinal Caco-2 cell line, expression of DUOXA2 mRNA was also positively modulated by IL-4 (show IL4 Antibodies) and IL-13 (show IL13 Antibodies).
DUOXA2 is Significantly Upregulated in Active Ulcerative Colitis and during Progression to Dysplasia.
This study is the first to report a novel c.413-414insA (Y138X) mutation for congenital hypothyroidism, thereby expanding the mutational spectrum of the DUOXA2 gene.
Two functionally important single-nucleotide polymorphisms within the promoter differentially regulate DUOX2 (show DUOX2 Antibodies)/DUOXA2 transcription in response to exogenous double-stranded DNA.
Native DUOXA2 would constrain DUOX2 (show DUOX2 Antibodies) to produce H(2)O(2).
Up-regulation and sustained activation of Stat1 (show STAT1 Antibodies) are essential for interferon-gamma (IFN-gamma (show IFNG Antibodies))-induced (show SAMHD1 Antibodies) dual oxidase 2 (Duox2 (show DUOX2 Antibodies)) and dual oxidase (show DUOX1 Antibodies) A2 (DuoxA2) expression in human pancreatic cancer cell lines.
co-expression of DUOXA2, an ER-resident transmembrane protein, allows ER-to-Golgi transition, maturation, and translocation to the plasma membrane of functional DUOX2 (show DUOX2 Antibodies) in a heterologous system
This gene encodes an endoplasmic reticulum protein that is necessary for proper cellular localization and maturation of functional dual oxidase 2. Mutations in this gene have been associated with thyroid dyshormonogenesis 5.
dual oxidase maturation factor 2
, dual oxidase maturation factor 2-like
, Numb-interacting protein 2