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Dual Oxidase Maturation Factor 2 Proteins (DUOXA2)

DUOXA2 encodes an endoplasmic reticulum protein that is necessary for proper cellular localization and maturation of functional dual oxidase 2. Additionally we are shipping DUOXA2 Antibodies (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DUOXA2 405753 Q1HG44
DUOXA2 66811 Q9D311
Rat DUOXA2 DUOXA2 499879  
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Top DUOXA2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details

DUOXA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
,

More Proteins for Dual Oxidase Maturation Factor 2 (DUOXA2) Interaction Partners

Human Dual Oxidase Maturation Factor 2 (DUOXA2) interaction partners

  1. inactivating mutations in the DUOXA2 (p.Y246X) and DUOX2 (show DUOX2 Proteins) (p.R885Q) genes were identified in a set of dizygotic twins with congenital hypothyroidism

  2. The folding of DUOX2 (show DUOX2 Proteins) appears to be a key event in the trafficking of the DUOX2 (show DUOX2 Proteins)/DUOXA2 complex as it promotes an appropriate conformation of the N-terminal region, which is propitious to subsequent covalent interactions with the maturation factor, DUOXA2.

  3. a novel DUOXA2 mutation (I26M) causing congenital hypothyroidism with goiter, which affected H2O2 generation but did not alter the protein expression levels, further confirming the essential role of DUOXA2 in thyroid hormone (show PTH Proteins) synthesis.

  4. The DUOX (show DUOX1 Proteins)-expressing model, the human intestinal Caco-2 cell line, expression of DUOXA2 mRNA was also positively modulated by IL-4 (show IL4 Proteins) and IL-13 (show IL13 Proteins).

  5. DUOXA2 is Significantly Upregulated in Active Ulcerative Colitis and during Progression to Dysplasia.

  6. This study is the first to report a novel c.413-414insA (Y138X) mutation for congenital hypothyroidism, thereby expanding the mutational spectrum of the DUOXA2 gene.

  7. Two functionally important single-nucleotide polymorphisms within the promoter differentially regulate DUOX2 (show DUOX2 Proteins)/DUOXA2 transcription in response to exogenous double-stranded DNA.

  8. Native DUOXA2 would constrain DUOX2 (show DUOX2 Proteins) to produce H(2)O(2).

  9. Up-regulation and sustained activation of Stat1 (show STAT1 Proteins) are essential for interferon-gamma (IFN-gamma (show IFNG Proteins))-induced (show SAMHD1 Proteins) dual oxidase 2 (Duox2 (show DUOX2 Proteins)) and dual oxidase (show DUOX1 Proteins) A2 (DuoxA2) expression in human pancreatic cancer cell lines.

  10. co-expression of DUOXA2, an ER-resident transmembrane protein, allows ER-to-Golgi transition, maturation, and translocation to the plasma membrane of functional DUOX2 (show DUOX2 Proteins) in a heterologous system

DUOXA2 Protein Profile

Protein Summary

This gene encodes an endoplasmic reticulum protein that is necessary for proper cellular localization and maturation of functional dual oxidase 2. Mutations in this gene have been associated with thyroid dyshormonogenesis 5.

Gene names and symbols associated with DUOXA2

  • dual oxidase maturation factor 1-like (DUOXA1L)
  • dual oxidase maturation factor 2 (DUOXA2)
  • dual oxidase maturation factor 2 (Duoxa2)
  • 9030623N16Rik protein
  • DUOXA1 protein
  • DUOXA2 protein
  • RGD1560628 protein
  • SIMNIPHOM protein
  • TDH5 protein

Protein level used designations for DUOXA2

dual oxidase maturation factor 2 , dual oxidase maturation factor 2-like , Numb-interacting protein 2

GENE ID SPECIES
427483 Gallus gallus
743164 Pan troglodytes
100379136 Ovis aries
405753 Homo sapiens
66811 Mus musculus
499879 Rattus norvegicus
609210 Canis lupus familiaris
514414 Bos taurus
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