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The protein encoded by DUSP11 is a member of the dual specificity protein phosphatase subfamily. Additionally we are shipping Dual Specificity Phosphatase 11 (RNA/RNP Complex 1-Interacting) Antibodies (22) and many more products for this protein.
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the atomic structure of a catalytically inactive mutant (C152S) of the human PIR1 phosphatase core (PIR1-core, residues 29-205), refined at 1.20 A resolution.
results suggest that DUSP11 contributes to p53 (show TP53 Proteins)-dependent inhibition of cell proliferation and that it might be involved in regulating RNA splicing through SAM68 (show KHDRBS1 Proteins)
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism.
RNA/RNP complex-1-interacting phosphatase
, RNA/RNP complex-interacting phosphatase
, dual specificity protein phosphatase 11
, phosphatase that interacts with RNA/RNP complex 1
, serine/threonine specific protein phosphatase