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Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. Additionally we are shipping Dual Specificity Phosphatase 14 Proteins (10) and many more products for this protein.
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Human Polyclonal DUSP14 Primary Antibody for WB - ABIN1881273
Patterson, Brummer, OBrien, Daly: Dual-specificity phosphatases: critical regulators with diverse cellular targets. in The Biochemical journal 2009
Show all 5 references for 1881273
Human Polyclonal DUSP14 Primary Antibody for ELISA, WB - ABIN184693
Marti, Krause, Post, Lyddane, Dupont, Sadelain, King: Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6. in Journal of immunology (Baltimore, Md. : 1950) 2001
The AA genotype was associated with protection against active TB. Among disease-free individuals, T-helper type-1 related genes, IFNGR2 (show IFNGR2 Antibodies) and STAT1 (show STAT1 Antibodies) mRNA levels significantly increased as the number of A alleles of rs1051838 increased.
levels significantly decreased in failing hearts
these findings reveal a novel mechanism by which TRAF2 (show TRAF2 Antibodies) mediates Lys63-linked ubiquitination of DUSP14, leading to DUSP14 activation in T cells
findings suggest that DUSP14 negatively regulates TNF (show TNF Antibodies)- or IL-1 (show IL1A Antibodies)-induced NF-kappaB (show NFKB1 Antibodies) activation by dephosphorylating TAK1 (show MAP3K7 Antibodies) at Thr (show TRH Antibodies)-187
DUSP14 may be a susceptibility gene for pulmonary tuberculosis.
The overproduction, purification and crystal structure at 1.88 A resolution of human dual-specificity phosphatase 14, DUSP14 (MKP6), are reported.
Activation of ATM (show ATM Antibodies) by radiation down-regulates phospho-ERK1/2 (show MAPK1/3 Antibodies) and its downstream signaling via increased expression of mitogen-activated protein kinase (show MAPK1 Antibodies) phosphatase MKP-1 (show DUSP1 Antibodies).
The binding of Lipomannan to TLR2 (show TLR2 Antibodies) triggers MAPK (show MAPK1 Antibodies) activation, followed by an up-regulation of MKP-1 (show DUSP1 Antibodies) expression, which in turn may act as a negative regulator of MAPK (show MAPK1 Antibodies) activation.
protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction possibly through inactivation of TAK1 (show NR2C2 Antibodies)-P38MAPK (show MAPK14 Antibodies)/-JNK1 (show MAPK8 Antibodies)/2 signaling pathway
DUSP14 negatively regulates TCR signaling and immune responses by inhibiting TAB1 (show TAB1 Antibodies) activation.
dual specificity phosphatases (Dusps) 6 and 14 are up-regulated by activation of beta-catenin (show CTNNB1 Antibodies) in murine liver cells
critical role for JNK1 (show MAPK8 Antibodies) in the regulation of Mkp1 (show DUSP1 Antibodies) induction and in LPS (show TLR4 Antibodies)-dependent macrophage activation.
knockdown of CREMalpha or DUSP14 or expression of a dominant-negative form of DUSP14 increased beta-cell line proliferation and enhanced the GLP-1 (show GCG Antibodies)-induced proliferation of primary beta-cells
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009
dual specificity phosphatase 14
, dual specificity protein phosphatase 14
, MAP kinase phosphatase 6
, MKP-1 like protein tyrosine phosphatase
, MKP-1-like protein tyrosine phosphatase
, mitogen-activated protein kinase phosphatase 6
, MAP kinase phsophatase 6
, Mkp-1 like protein tyrosine phosphatase