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Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity (By similarity). Additionally we are shipping DUSP26 Proteins (7) and many more products for this protein.
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results suggest that AK2 (show AK2 Antibodies) is an associated activator of DUSP26 and suppresses cell proliferation by FADD (show FADD Antibodies) dephosphorylation, postulating AK2 (show AK2 Antibodies) as a negative regulator of tumour growth.
The study reports the 1.68 A crystal structure of a catalytically inactive mutant (Cys152Ser) of DUSP26 lacking the first 60 N-terminal residues (DeltaN60-C/S-DUSP26).
DUSP26 may function as a tumour suppressor in particular cancers.
DUSP26 functions as a p53 (show TP53 Antibodies) phosphatase
DUSP26 effectively dephosphorylates p38 (show CRK Antibodies) and has a little effect on extracellular signal-regulated kinase in anaplastic thyroid cancer.
Downregulation of Dusp26 may contribute to malignant phenotypes of glioma.
DUSP26 down-regulation is an effective antineoplastic neuroblastoma (show ARHGEF16 Antibodies) strategy through activation of the p53 (show TP53 Antibodies) and p38 MAPK (show MAPK14 Antibodies) tumor-suppressor pathways.
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity (By similarity).
, MAP kinase phosphatase 8
, Novel amplified gene in thyroid anaplastic cancer
, dual specificity phosphatase SKRP3
, dual specificity protein phosphatase 26
, dual-specificity phosphatase SKRP3
, low-molecular-mass dual-specificity phosphatase 4
, mitogen-activated protein kinase phosphatase 8