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Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity (By similarity). Additionally we are shipping DUSP26 Antibodies (65) and many more products for this protein.
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Enhanced expression of DUSP26 was observed in the hippocampus of Alzheimer's disease patients.
results suggest that AK2 (show AK2 Proteins) is an associated activator of DUSP26 and suppresses cell proliferation by FADD (show FADD Proteins) dephosphorylation, postulating AK2 (show AK2 Proteins) as a negative regulator of tumour growth.
The study reports the 1.68 A crystal structure of a catalytically inactive mutant (Cys152Ser) of DUSP26 lacking the first 60 N-terminal residues (DeltaN60-C/S-DUSP26).
DUSP26 may function as a tumour suppressor in particular cancers.
DUSP26 functions as a p53 (show TP53 Proteins) phosphatase
DUSP26 effectively dephosphorylates p38 (show CRK Proteins) and has a little effect on extracellular signal-regulated kinase in anaplastic thyroid cancer.
Downregulation of Dusp26 may contribute to malignant phenotypes of glioma.
DUSP26 down-regulation is an effective antineoplastic neuroblastoma (show ARHGEF16 Proteins) strategy through activation of the p53 (show TP53 Proteins) and p38 MAPK (show MAPK14 Proteins) tumor-suppressor pathways.
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity (By similarity).
, MAP kinase phosphatase 8
, Novel amplified gene in thyroid anaplastic cancer
, dual specificity phosphatase SKRP3
, dual specificity protein phosphatase 26
, dual-specificity phosphatase SKRP3
, low-molecular-mass dual-specificity phosphatase 4
, mitogen-activated protein kinase phosphatase 8