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The protein encoded by DUSP5 is a member of the dual specificity protein phosphatase subfamily. Additionally we are shipping DUSP5 Antibodies (59) and DUSP5 Proteins (6) and many more products for this protein.
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Dusp-5 and Snrk-1 control an (show SNRK ELISA Kits)gioblast populations in the lateral plate mesoderm with Dusp-5 functioning downstream of Snrk-1
The DUSP5 S147P protein is hypoactive compared to the DUSP5 wild-type protein.
Data indicate that cells from Burkitt's lymphoma, leukemia, neuroblastoma (show ARHGEF16 ELISA Kits) and Ewing sarcoma showed a higher dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1)/dual specificity phosphatase 5 (DUSP5 ratio than normal cells.
DUSP1 (show DUSP1 ELISA Kits), DUSP4 (show DUSP4 ELISA Kits), and DUSP5 differentially modulate endothelial MAPK (show MAPK1 ELISA Kits) signaling pathways downstream of Tie-2 (show TEK ELISA Kits) receptors.
DUSP5 methylation may serve as a prognostic marker for gastric cancer (GC), but this requires validation in a larger set of GC samples.
Studies indicate that dual-specificity MAP kinase (show MAPK1 ELISA Kits) phosphatases (MKPs) DUSP6/MKP-3 (show DUSP6 ELISA Kits) and DUSP5 are localized in the cytoplasm and nuclear compartments.
DUSP5 and DUSP6 (show DUSP6 ELISA Kits) selectively control ERK (show EPHB2 ELISA Kits) pathway activity and proliferation.
the differential up-regulation of MKP3 (show DUSP6 ELISA Kits) by Ets2 (show ETS2 ELISA Kits) and of DUSP5 by c-Jun (show JUN ELISA Kits) may converge in similar functional roles for these MAP kinase (show MAPK1 ELISA Kits) phosphatases in the growth arrest versus proliferation decisions of breast cancer cells
In FD-Fms cells, overexpression of human DUS (show CSF1R ELISA Kits)P5 increased M-CSF-depende (show CSF1 ELISA Kits)nt proliferation & decreased differentiation. Overexpression in multipotent EGER-Fms cells increa (show CSF1 ELISA Kits)sed M-CSF-induced proliferation & caused granulocytic, not macrophage, differentiati (show MAPK1/3 ELISA Kits)on.
DUSP5 is a direct target of p53 (show TP53 ELISA Kits).
DUSP5 inactivates ERK2 (show MAPK1 ELISA Kits) and causes both nuclear translocation and sequestration of inactive ERK2 (show MAPK1 ELISA Kits).
DUSP5 phosphatase is regulated at the transcriptional level by the MAPK (show MAPK1 ELISA Kits) pathway and that serum responsive element is involved in the regulation of this early response gene.
results suggest an in vivo role for DUSP5 as a tumor suppressor by modulating the oncogenic potential of activated Ras in the epidermis
After SSH between cDNA libraries from FD-Fms (show CSF1R ELISA Kits) cells stimulated by M-CSF (show CSF1R ELISA Kits) in the presence or the absence of U0126, we isolated DUSP5. DUSP5 expression is induced by M-CSF (show CSF1R ELISA Kits) in various myeloid cells & acts as a specific negative-feedback regulator of ERK1/2 (show MAPK1/3 ELISA Kits).
proper regulation of DUSP5 activity is critical for normal immune system development, IL-2 (show IL2 ELISA Kits) actions, and tolerance
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.
dual specificity protein phosphatase 5-like
, dual specificity phosphatase 5
, dual specificity protein phosphatase 5
, VH1-like phosphatase 3
, dual specificity protein phosphatase hVH3
, serine/threonine specific protein phosphatase
, MAP-kinase phosphatase (cpg21)
, MAP-kinase phosphatase CPG21
, candidate plasticity-related gene 21