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Dual Specificity Phosphatase 5 Proteins (DUSP5)

The protein encoded by DUSP5 is a member of the dual specificity protein phosphatase subfamily. Additionally we are shipping DUSP5 Antibodies (59) and DUSP5 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DUSP5 1847 Q16690
DUSP5 171109 O54838
Mouse DUSP5 DUSP5 240672  
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Top DUSP5 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days

DUSP5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Rat (Rattus)

More Proteins for Dual Specificity Phosphatase 5 (DUSP5) Interaction Partners

Zebrafish Dual Specificity Phosphatase 5 (DUSP5) interaction partners

  1. Dusp-5 and Snrk-1 control an (show SNRK Proteins)gioblast populations in the lateral plate mesoderm with Dusp-5 functioning downstream of Snrk-1

Human Dual Specificity Phosphatase 5 (DUSP5) interaction partners

  1. The DUSP5 S147P protein is hypoactive compared to the DUSP5 wild-type protein.

  2. Data indicate that cells from Burkitt's lymphoma, leukemia, neuroblastoma (show ARHGEF16 Proteins) and Ewing sarcoma showed a higher dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1)/dual specificity phosphatase 5 (DUSP5 ratio than normal cells.

  3. DUSP1 (show DUSP1 Proteins), DUSP4 (show DUSP4 Proteins), and DUSP5 differentially modulate endothelial MAPK (show MAPK1 Proteins) signaling pathways downstream of Tie-2 (show TEK Proteins) receptors.

  4. DUSP5 methylation may serve as a prognostic marker for gastric cancer (GC), but this requires validation in a larger set of GC samples.

  5. Studies indicate that dual-specificity MAP kinase (show MAPK1 Proteins) phosphatases (MKPs) DUSP6/MKP-3 (show DUSP6 Proteins) and DUSP5 are localized in the cytoplasm and nuclear compartments.

  6. DUSP5 and DUSP6 (show DUSP6 Proteins) selectively control ERK (show EPHB2 Proteins) pathway activity and proliferation.

  7. the differential up-regulation of MKP3 (show DUSP6 Proteins) by Ets2 (show ETS2 Proteins) and of DUSP5 by c-Jun (show JUN Proteins) may converge in similar functional roles for these MAP kinase (show MAPK1 Proteins) phosphatases in the growth arrest versus proliferation decisions of breast cancer cells

  8. In FD-Fms cells, overexpression of human DUSP5 increased M-CSF-dependent proliferation & decreased differentiation. Overexpression in multipotent EGER-Fms cells increased M-CSF-induced proliferation & caused granulocytic, not macrophage, differentiation.

  9. DUSP5 is a direct target of p53 (show TP53 Proteins).

  10. DUSP5 inactivates ERK2 (show MAPK1 Proteins) and causes both nuclear translocation and sequestration of inactive ERK2 (show MAPK1 Proteins).

Mouse (Murine) Dual Specificity Phosphatase 5 (DUSP5) interaction partners

  1. DUSP5 phosphatase is regulated at the transcriptional level by the MAPK (show MAPK1 Proteins) pathway and that serum responsive element is involved in the regulation of this early response gene.

  2. results suggest an in vivo role for DUSP5 as a tumor suppressor by modulating the oncogenic potential of activated Ras in the epidermis

  3. After SSH between cDNA libraries from FD-Fms cells stimulated by M-CSF in the presence or the absence of U0126, we isolated DUSP5. DUSP5 expression is induced by M-CSF in various myeloid cells & acts as a specific negative-feedback regulator of ERK1/2.

  4. proper regulation of DUSP5 activity is critical for normal immune system development, IL-2 (show IL2 Proteins) actions, and tolerance

DUSP5 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.

Gene names and symbols associated with DUSP5

  • dual specificity phosphatase 5 (DUSP5)
  • dual specificity phosphatase 5 (dusp5)
  • dual specificity phosphatase 5 (Dusp5)
  • Cpg21 protein
  • DUSP protein
  • DUSP5 protein
  • Gm337 protein
  • HVH3 protein
  • MGC84792 protein
  • wu:fc03b11 protein
  • wu:fc86e02 protein

Protein level used designations for DUSP5

dual specificity protein phosphatase 5-like , dual specificity phosphatase 5 , dual specificity protein phosphatase 5 , VH1-like phosphatase 3 , dual specificity protein phosphatase hVH3 , serine/threonine specific protein phosphatase , MAP-kinase phosphatase (cpg21) , MAP-kinase phosphatase CPG21 , candidate plasticity-related gene 21

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444752 Xenopus laevis
486884 Canis lupus familiaris
548573 Xenopus (Silurana) tropicalis
100343162 Oryctolagus cuniculus
100157144 Sus scrofa
100583427 Nomascus leucogenys
1847 Homo sapiens
171109 Rattus norvegicus
240672 Mus musculus
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